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Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut

Author

Listed:
  • Ana Popovic

    (Program in Molecular Medicine, Hospital for Sick Children Research Institute
    University of Toronto)

  • Celine Bourdon

    (Hospital for Sick Children
    Hospital for Sick Children)

  • Pauline W. Wang

    (University of Toronto
    University of Toronto)

  • David S. Guttman

    (University of Toronto
    University of Toronto)

  • Sajid Soofi

    (The Aga Khan University)

  • Zulfiqar A. Bhutta

    (Hospital for Sick Children
    The Aga Khan University)

  • Robert H. J. Bandsma

    (Hospital for Sick Children
    Hospital for Sick Children)

  • John Parkinson

    (Program in Molecular Medicine, Hospital for Sick Children Research Institute
    University of Toronto
    University of Toronto)

  • Lisa G. Pell

    (Hospital for Sick Children)

Abstract

Supplementation with micronutrients, including vitamins, iron and zinc, is a key strategy to alleviate child malnutrition. However, association of gastrointestinal disorders with iron has led to ongoing debate over their administration. To better understand their impact on gut microbiota, we analyse the bacterial, protozoal, fungal and helminth communities of stool samples collected from a subset of 80 children at 12 and 24 months of age, previously enrolled into a large cluster randomized controlled trial of micronutrient supplementation in Pakistan (ClinicalTrials.gov identifier NCT00705445). We show that while bacterial diversity is reduced in supplemented children, vitamins and iron (as well as residence in a rural setting) may promote colonization with distinct protozoa and mucormycetes, whereas the addition of zinc appears to ameliorate this effect. We suggest that the risks and benefits of micronutrient interventions may depend on eukaryotic communities, potentially exacerbated by exposure to a rural setting. Larger studies are needed to evaluate the clinical significance of these findings and their impact on health outcomes.

Suggested Citation

  • Ana Popovic & Celine Bourdon & Pauline W. Wang & David S. Guttman & Sajid Soofi & Zulfiqar A. Bhutta & Robert H. J. Bandsma & John Parkinson & Lisa G. Pell, 2021. "Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27010-3
    DOI: 10.1038/s41467-021-27010-3
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    1. Sathish Subramanian & Sayeeda Huq & Tanya Yatsunenko & Rashidul Haque & Mustafa Mahfuz & Mohammed A. Alam & Amber Benezra & Joseph DeStefano & Martin F. Meier & Brian D. Muegge & Michael J. Barratt & , 2014. "Persistent gut microbiota immaturity in malnourished Bangladeshi children," Nature, Nature, vol. 510(7505), pages 417-421, June.
    2. Zachary D Kurtz & Christian L Müller & Emily R Miraldi & Dan R Littman & Martin J Blaser & Richard A Bonneau, 2015. "Sparse and Compositionally Robust Inference of Microbial Ecological Networks," PLOS Computational Biology, Public Library of Science, vol. 11(5), pages 1-25, May.
    3. Christopher J. Stewart & Nadim J. Ajami & Jacqueline L. O’Brien & Diane S. Hutchinson & Daniel P. Smith & Matthew C. Wong & Matthew C. Ross & Richard E. Lloyd & HarshaVardhan Doddapaneni & Ginger A. M, 2018. "Temporal development of the gut microbiome in early childhood from the TEDDY study," Nature, Nature, vol. 562(7728), pages 583-588, October.
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    Cited by:

    1. Zhongmin Dai & Xu Guo & Jiahui Lin & Xiu Wang & Dan He & Rujiong Zeng & Jun Meng & Jipeng Luo & Manuel Delgado-Baquerizo & Eduardo Moreno-Jiménez & Philip C. Brookes & Jianming Xu, 2023. "Metallic micronutrients are associated with the structure and function of the soil microbiome," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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