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Persistent gut microbiota immaturity in malnourished Bangladeshi children

Author

Listed:
  • Sathish Subramanian

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

  • Sayeeda Huq

    (Centre for Nutrition and Food Security, International Centre for Diarrhoeal Disease Research, Dhaka 1212, Bangladesh)

  • Tanya Yatsunenko

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

  • Rashidul Haque

    (Centre for Nutrition and Food Security, International Centre for Diarrhoeal Disease Research, Dhaka 1212, Bangladesh)

  • Mustafa Mahfuz

    (Centre for Nutrition and Food Security, International Centre for Diarrhoeal Disease Research, Dhaka 1212, Bangladesh)

  • Mohammed A. Alam

    (Centre for Nutrition and Food Security, International Centre for Diarrhoeal Disease Research, Dhaka 1212, Bangladesh)

  • Amber Benezra

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis
    New School for Social Research)

  • Joseph DeStefano

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

  • Martin F. Meier

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

  • Brian D. Muegge

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

  • Michael J. Barratt

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

  • Laura G. VanArendonk

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

  • Qunyuan Zhang

    (Washington University in St. Louis)

  • Michael A. Province

    (Washington University in St. Louis)

  • William A. Petri Jr

    (Microbiology and Pathology, University of Virginia School of Medicine)

  • Tahmeed Ahmed

    (Centre for Nutrition and Food Security, International Centre for Diarrhoeal Disease Research, Dhaka 1212, Bangladesh)

  • Jeffrey I. Gordon

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

Abstract

Bacterial species whose representation defines healthy postnatal assembly of the gut microbiota in Bangladeshi children during their first 2 years are identified, and a model is constructed to compare healthy children to those with severe acute malnutrition (SAM); results show that SAM is associated with microbiota immaturity that is only partially ameliorated by existing nutritional interventions.

Suggested Citation

  • Sathish Subramanian & Sayeeda Huq & Tanya Yatsunenko & Rashidul Haque & Mustafa Mahfuz & Mohammed A. Alam & Amber Benezra & Joseph DeStefano & Martin F. Meier & Brian D. Muegge & Michael J. Barratt & , 2014. "Persistent gut microbiota immaturity in malnourished Bangladeshi children," Nature, Nature, vol. 510(7505), pages 417-421, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7505:d:10.1038_nature13421
    DOI: 10.1038/nature13421
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    Cited by:

    1. Minghua Tang, 2018. "Protein Intake during the First Two Years of Life and Its Association with Growth and Risk of Overweight," IJERPH, MDPI, vol. 15(8), pages 1-8, August.
    2. Johannes Haushofer & Michael Kremer & Ricardo Maertens & Brandon Joel Tan, 2021. "Water Treatment and Child Mortality: Evidence from Kenya," NBER Working Papers 29447, National Bureau of Economic Research, Inc.
    3. Ruairi C. Robertson & Thaddeus J. Edens & Lynnea Carr & Kuda Mutasa & Ethan K. Gough & Ceri Evans & Hyun Min Geum & Iman Baharmand & Sandeep K. Gill & Robert Ntozini & Laura E. Smith & Bernard Chasekw, 2023. "The gut microbiome and early-life growth in a population with high prevalence of stunting," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Yohannes Seyoum & Valérie Greffeuille & Dorgeles Kouakou Dje Kouadio & Khov Kuong & Williams Turpin & Rachida M’Rabt & Vincent Chochois & Sonia Fortin & Marlène Perignon & Marion Fiorentino & Jacques , 2024. "Faecal microbiota of schoolchildren is associated with nutritional status and markers of inflammation: a double-blinded cluster-randomized controlled trial using multi-micronutrient fortified rice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    5. K. E. Huus & T. T. Hoang & A. Creus-Cuadros & M. Cirstea & S. L. Vogt & K. Knuff-Janzen & P. J. Sansonetti & P. Vonaesch & B. B. Finlay, 2021. "Cross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    6. Ren Dodge & Eric W. Jones & Haolong Zhu & Benjamin Obadia & Daniel J. Martinez & Chenhui Wang & Andrés Aranda-Díaz & Kevin Aumiller & Zhexian Liu & Marco Voltolini & Eoin L. Brodie & Kerwyn Casey Huan, 2023. "A symbiotic physical niche in Drosophila melanogaster regulates stable association of a multi-species gut microbiota," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    7. Marta Reyman & Marlies A. Houten & Rebecca L. Watson & Mei Ling J. N. Chu & Kayleigh Arp & Wouter J. Waal & Irene Schiering & Frans B. Plötz & Rob J. L. Willems & Willem Schaik & Elisabeth A. M. Sande, 2022. "Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    8. Ana Popovic & Celine Bourdon & Pauline W. Wang & David S. Guttman & Sajid Soofi & Zulfiqar A. Bhutta & Robert H. J. Bandsma & John Parkinson & Lisa G. Pell, 2021. "Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    9. Fanette Fontaine & Sondra Turjeman & Karel Callens & Omry Koren, 2023. "The intersection of undernutrition, microbiome, and child development in the first years of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    10. Alan Le Goallec & Braden T Tierney & Jacob M Luber & Evan M Cofer & Aleksandar D Kostic & Chirag J Patel, 2020. "A systematic machine learning and data type comparison yields metagenomic predictors of infant age, sex, breastfeeding, antibiotic usage, country of origin, and delivery type," PLOS Computational Biology, Public Library of Science, vol. 16(5), pages 1-21, May.

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