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A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease

Author

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  • Runtan Cheng

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Lu Wang

    (Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences)

  • Shenglong Le

    (Shanghai Jiao Tong University
    University of Jyväskylä)

  • Yifan Yang

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Can Zhao

    (Shanghai University of Sport)

  • Xiangqi Zhang

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Xin Yang

    (Shanghai Jiao Tong University)

  • Ting Xu

    (Shanghai Jiao Tong University)

  • Leiting Xu

    (Shanghai Jiao Tong University
    Ningbo University, School of Medicine)

  • Petri Wiklund

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Jun Ge

    (Shanghai Jiao Tong University
    Shidong Hospital of Yangpu District)

  • Dajiang Lu

    (Shanghai Jiao Tong University
    Shanghai University of Sport)

  • Chenhong Zhang

    (Shanghai Jiao Tong University
    School of Life Sciences and Biotechnology, Shanghai Jiao Tong University)

  • Luonan Chen

    (Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Guangdong Institute of Intelligence Science and Technology)

  • Sulin Cheng

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University
    University of Jyväskylä)

Abstract

Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, n = 28; Aerobic exercise + Diet, n = 29; No intervention, n = 29) randomized, singe blinded (for researchers), and controlled intervention in patients with NAFLD and prediabetes to assess the effect of interventions on the primary outcomes of liver fat content and glucose metabolism. Here we report the third primary outcome of the trial—gut microbiota composition—in participants who completed the trial (22 in Aerobic exercise, 22 in Diet, 23 in Aerobic exercise + Diet, 18 in No Intervention). We show that combined aerobic exercise and diet intervention are associated with diversified and stabilized keystone taxa, while exercise and diet interventions alone increase network connectivity and robustness between taxa. No adverse effects were observed with the interventions. In addition, in exploratory ad-hoc analyses we find that not all subjects responded to the intervention in a similar manner, when using differentially altered gut microbe amplicon sequence variants abundance to classify the responders and low/non-responders. A personalized gut microbial network at baseline could predict the individual responses in liver fat to exercise intervention. Our findings suggest an avenue for developing personalized intervention strategies for treatment of NAFLD based on host-gut microbiome ecosystem interactions, however, future studies with large sample size are needed to validate these discoveries. The Trial Registration Number is ISRCTN 42622771.

Suggested Citation

  • Runtan Cheng & Lu Wang & Shenglong Le & Yifan Yang & Can Zhao & Xiangqi Zhang & Xin Yang & Ting Xu & Leiting Xu & Petri Wiklund & Jun Ge & Dajiang Lu & Chenhong Zhang & Luonan Chen & Sulin Cheng, 2022. "A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29968-0
    DOI: 10.1038/s41467-022-29968-0
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