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Screening Potential Nitrification Inhibitors through a Structure–Activity Relationship Study—The Case of Cinnamic Acid Derivatives

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  • Jie Zhang

    (Jiangxi Provincial Engineering Research Center for Seed-Breeding and Utilization of Camphor Trees, Nanchang Institute of Technology, Nanchang 330099, China)

  • Jia Liu

    (Soil and Fertilizer & Resources and Environment Institute, Jiangxi Academy of Agricultural Sciences, Nanchang 330200, China)

  • Guilong Li

    (Soil and Fertilizer & Resources and Environment Institute, Jiangxi Academy of Agricultural Sciences, Nanchang 330200, China)

  • Meng Wu

    (State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China)

Abstract

Using a nitrification inhibitor to decrease nitrification rates in soil represents a promising strategy to improve nitrogen fertilizer use efficiency. Nonetheless, rapid screening of nitrification inhibitors remains challenging. In this study, we propose a strategy to screen potential nitrification inhibitors through a structure–activity relationship (SAR) study based on a rapid determination of nitrification inhibition. To demonstrate this, the nitrification inhibition potentials of cinnamic acid derivatives against Nitrosomonas europaea growth were evaluated in a liquid culture. The SAR study showed that hydroxyl and fluoride groups were the favorable substituents on the benzene ring, and the ester group and double bond in the side chain were essential for maintaining high inhibition efficacy. Three compounds with notable inhibitory efficacy (EC 50 = 8–25 μM) were further assessed in agricultural soil, and they displayed a noteworthy reduction in nitrification rate and bacterial amoA gene numbers. Based on the results, we identified methyl cinnamate, methyl 4-hydroxycinnamate, and methyl 4-fluorocinnamate as promising candidates for nitrification inhibition.

Suggested Citation

  • Jie Zhang & Jia Liu & Guilong Li & Meng Wu, 2024. "Screening Potential Nitrification Inhibitors through a Structure–Activity Relationship Study—The Case of Cinnamic Acid Derivatives," Sustainability, MDPI, vol. 16(13), pages 1-10, July.
    • Handle: RePEc:gam:jsusta:v:16:y:2024:i:13:p:5791-:d:1430612
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    References listed on IDEAS

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    1. Nicolas Gruber & James N. Galloway, 2008. "An Earth-system perspective of the global nitrogen cycle," Nature, Nature, vol. 451(7176), pages 293-296, January.
    2. Y.P. Kou & K. Wei & G.X. Chen & Z.Y. Wang & H. Xu, 2015. "Effects of 3,4-dimethylpyrazole phosphate and dicyandiamide on nitrous oxide emission in a greenhouse vegetable soil," Plant, Soil and Environment, Czech Academy of Agricultural Sciences, vol. 61(1), pages 29-35.
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