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Genome-Wide Association Study Based on Plant Height and Drought-Tolerance Indices Reveals Two Candidate Drought-Tolerance Genes in Sweet Sorghum

Author

Listed:
  • Yue Xin

    (College of Agriculture, Tarim University, Alar 843300, China)

  • Lina Gao

    (College of Agriculture, Tarim University, Alar 843300, China)

  • Wenming Hu

    (College of Agriculture, Tarim University, Alar 843300, China)

  • Qi Gao

    (College of Agriculture, Tarim University, Alar 843300, China)

  • Bin Yang

    (College of Agriculture, Tarim University, Alar 843300, China)

  • Jianguo Zhou

    (College of Agriculture, Tarim University, Alar 843300, China)

  • Cuilian Xu

    (College of Agriculture, Tarim University, Alar 843300, China)

Abstract

To understand the molecular mechanism of drought tolerance in sweet sorghum [ Sorghum bicolor (L.) Moench], we found the genetic loci associated with single nucleotide polymorphism (SNP) markers and explored drought-tolerance candidate genes. A genome-wide association study (GWAS) of sweet sorghum was performed using the general linear model (GLM), mixed linear model (MLM) and the fixed and random model circulating probability unification (FarmCPU) method in R. Mean productivity (MP), relative drought index (RDI) and stress-tolerance index (STI), based on plant height under two water treatments, were obtained from 354 sweet sorghum accessions from home and abroad. These plant-height drought-tolerance indices showed continuous quantitative variation. Except for the RDI, the others were close to normal distribution. A total of 6186 SNPs were obtained from the resequencing data after quality control and filling. The marker densities on chromosomes 9, 10 and 5 were higher than those on other chromosomes, which were 40.4, 16.5 and 10.0 SNPs within 1 Mb, respectively. The GWAS results showed that 49, 5 and 25 significant SNP loci were detected by the GLM, the MLM and FarmCPU, respectively, many of which were detected by two or more models. Two candidate genes of drought tolerance were annotated: Sb08g019720.1 , homologous to the gene encoding the early flowering MYB protein transcription factor in Arabidopsis thaliana ; and Sb01g037050.1 , homologous to the gene encoding the basic leucine zipper transcription factor in maize. The results of this study can facilitate the cultivar development of drought-tolerant sweet sorghum.

Suggested Citation

  • Yue Xin & Lina Gao & Wenming Hu & Qi Gao & Bin Yang & Jianguo Zhou & Cuilian Xu, 2022. "Genome-Wide Association Study Based on Plant Height and Drought-Tolerance Indices Reveals Two Candidate Drought-Tolerance Genes in Sweet Sorghum," Sustainability, MDPI, vol. 14(21), pages 1-14, November.
    • Handle: RePEc:gam:jsusta:v:14:y:2022:i:21:p:14339-:d:961560
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    References listed on IDEAS

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    1. Xiaolei Liu & Meng Huang & Bin Fan & Edward S Buckler & Zhiwu Zhang, 2016. "Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies," PLOS Genetics, Public Library of Science, vol. 12(2), pages 1-24, February.
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    1. Theivanayagam Maharajan & Thumadath Palayullaparambil Ajeesh Krishna & Neenthamadathil Mohandas Krishnakumar & Mani Vetriventhan & Himabindu Kudapa & Stanislaus Antony Ceasar, 2024. "Role of Genome Sequences of Major and Minor Millets in Strengthening Food and Nutritional Security for Future Generations," Agriculture, MDPI, vol. 14(5), pages 1-28, April.

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