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Biomonitoring of Hydroxylated Polycyclic Aromatic Hydrocarbon Metabolites in Workers at a Waste-to-Energy Incinerator, Turin, Italy

Author

Listed:
  • Elena Farina

    (Department of Epidemiology, ASL TO3, Via Martiri XXX Aprile 30, 10093 Collegno (Turin), Italy)

  • Anna Laura Iamiceli

    (Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy)

  • Manuela Orengia

    (Department of Epidemiology and Environmental Health, Regional Environmental Protection Agency, Via Pio VII 9, 10135 Turin, Italy)

  • Martina Gandini

    (Department of Epidemiology and Environmental Health, Regional Environmental Protection Agency, Via Pio VII 9, 10135 Turin, Italy)

  • Laura Crosetto

    (Department of Epidemiology and Environmental Health, Regional Environmental Protection Agency, Via Pio VII 9, 10135 Turin, Italy)

  • Vittorio Abate

    (Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy)

  • Stefania Paola De Filippis

    (Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy)

  • Silvia De Luca

    (Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy)

  • Nicola Iacovella

    (Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy)

  • Elena De Felip

    (Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy)

  • Antonella Bena

    (Department of Epidemiology, ASL TO3, Via Martiri XXX Aprile 30, 10093 Collegno (Turin), Italy)

Abstract

This paper presents the results of the human biomonitoring of ten urinary OH-PAHs (hydroxylated polycyclic aromatic hydrocarbon) in a cohort of workers at an incinerator in Turin, Italy. Long-term exposure was assessed through repeated measurements at three time points: before the startup (T0), after 1 year (T1), and after 3 years (T2). Paired data were available for 26 subjects, seven administrative workers (AWs) and 19 plant workers (PWs). Short-term exposure was assessed by comparing start-end shift measurements. Due to the non-normal distribution of the data, the nonparametric Cuzick’s test for trend and the Wilcoxon signed-rank test for paired samples were used. Neither the trend nor the T0-T2 comparison tests resulted in statistically significant outputs in the two groups (q-value > 0.05), even when controlling for smoking habits. In relation to PWs, some of the metabolites were higher at T2 with respect to T0, but no linear increase was found. Conversely, 1-OH-PYR (ng/g creatinine) showed lower median values at T1 (61.5) and T2 (67) compared to the baseline (151.3). Similarly, short-term comparisons yielded no significant results, with rather overlapping distributions of values. Overall, no significant increases in metabolite levels were detected as a result of occupational exposure in the incinerator workers considered. These findings align with previous results for metals and ambient air measurements.

Suggested Citation

  • Elena Farina & Anna Laura Iamiceli & Manuela Orengia & Martina Gandini & Laura Crosetto & Vittorio Abate & Stefania Paola De Filippis & Silvia De Luca & Nicola Iacovella & Elena De Felip & Antonella B, 2025. "Biomonitoring of Hydroxylated Polycyclic Aromatic Hydrocarbon Metabolites in Workers at a Waste-to-Energy Incinerator, Turin, Italy," IJERPH, MDPI, vol. 22(1), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:22:y:2025:i:1:p:77-:d:1562898
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    References listed on IDEAS

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    1. Yoav Benjamini & Daniel Yekutieli, 2005. "False Discovery Rate-Adjusted Multiple Confidence Intervals for Selected Parameters," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 71-81, March.
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