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Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Author

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  • Sang-Dol Kim

    (Department of Nursing, College of Health Science, Kangwon National University, Samcheok 25949, Korea)

  • Young-Ran Yeun

    (Department of Nursing, College of Health Science, Kangwon National University, Samcheok 25949, Korea)

Abstract

Chronic low-grade inflammation that accompanies aging is associated with adverse health outcomes and may exacerbate the severity of infectious disease such as COVID-19. Resistance training (RT) has the potential to improve chronic low-grade inflammation, but the evidence remains inconclusive. This study evaluated the effects of RT on chronic low-grade inflammation in elderly adults. MEDLINE, EMBASE, Cochrane Library, CINAHL, RISS, NDSL, and KoreaMed were searched. We included studies that assessed the effect of RT on C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α in those aged ≥60 years. The effect size was estimated using fixed or random-effects models. Subgroup analysis was performed regarding age, health status, training method, number of exercises, intensity, weekly frequency, and duration. In the 18 randomized controlled trials (539 patients) included, RT was effective in alleviating CRP (effect size = −0.72, 95% confidence interval = −1.06 to −0.38, p < 0.001), IL-10 (−3.34, −6.16 to −0.53, p = 0.02), and TNF-α (−0.56, −1.08 to −0.03, p = 0.04) in elderly adults and tended to reduce IL-6 (−0.59, −1.18 to 0.00, p = 0.05). Subgroup analyses showed CRP reduction regardless of age, training method, number of exercises, intensity, weekly frequency, and duration. RT can be used to ameliorate chronic low-grade inflammation in elderly adults.

Suggested Citation

  • Sang-Dol Kim & Young-Ran Yeun, 2022. "Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3434-:d:771037
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    References listed on IDEAS

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    1. Camilo Germán Alberto Pérez Chaparro & Philipp Zech & Felipe Schuch & Bernd Wolfarth & Michael Rapp & Andreas Heiβel, 2018. "Effects of aerobic and resistance exercise alone or combined on strength and hormone outcomes for people living with HIV. A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-21, September.
    2. Andrew T. Levin & William P. Hanage & Nana Owusu-Boaitey & Kensington B. Cochran & Seamus P. Walsh & Gideon Meyerowitz-Katz, 2020. "Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-analysis, & Public Policy Implications," NBER Working Papers 27597, National Bureau of Economic Research, Inc.
    3. Denisa Margină & Anca Ungurianu & Carmen Purdel & Dimitris Tsoukalas & Evangelia Sarandi & Maria Thanasoula & Fotios Tekos & Robin Mesnage & Demetrios Kouretas & Aristidis Tsatsakis, 2020. "Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors," IJERPH, MDPI, vol. 17(11), pages 1-27, June.
    4. Paola Gonzalo-Encabo & Gonzalo Maldonado & David Valadés & Carmen Ferragut & Alberto Pérez-López, 2021. "The Role of Exercise Training on Low-Grade Systemic Inflammation in Adults with Overweight and Obesity: A Systematic Review," IJERPH, MDPI, vol. 18(24), pages 1-17, December.
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    1. Haotian Zhao & Zhijian He & Hezhang Yun & Ruifu Wang & Chang Liu, 2022. "A Meta-Analysis of the Effects of Different Exercise Modes on Inflammatory Response in the Elderly," IJERPH, MDPI, vol. 19(16), pages 1-13, August.

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