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Coffee Consumption, Genetic Polymorphisms, and the Risk of Type 2 Diabetes Mellitus: A Pooled Analysis of Four Prospective Cohort Studies

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  • An Na Kim

    (Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea)

  • Hyun Jeong Cho

    (Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea)

  • Jiyoung Youn

    (Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea)

  • Taiyue Jin

    (Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea)

  • Moonil Kang

    (Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul 08826, Korea)

  • Joohon Sung

    (Department of Epidemiology, School of Public Health, Seoul National University, Seoul 08826, Korea)

  • Jung Eun Lee

    (Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea
    The Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea)

Abstract

The association between coffee consumption and the risk of type 2 diabetes may vary by genetic variants. Our study addresses the question of whether the incidence of type 2 diabetes is related to the consumption of coffee and whether this relationship is modified by polymorphisms related to type 2 diabetes. We performed a pooled analysis of four Korean prospective studies that included 71,527 participants; median follow-up periods ranged between 2 and 13 years. All participants had completed a validated food-frequency questionnaire (FFQ) at baseline. The odds ratios (ORs) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using logistic regression models. The ORs were combined using a fixed or random effects model depending on the heterogeneity across the studies. Compared with 0 to <0.5 cups/day of coffee consumption, the OR for type 2 diabetes was 0.89 (95% CI: 0.80–0.98, p for trend = 0.01) for ≥3 cups/day of coffee consumption. We did not observe significant interactions by five single nucleotide polymorphisms (SNPs) related to type 2 diabetes ( CDKAL1 rs7756992, CDKN2A /B rs10811661, KCNJ11 rs5215, KCNQ1 rs163184, and PEPD rs3786897) in the association between coffee and the risk of type 2 diabetes. We found that coffee consumption was inversely associated with the risk of type 2 diabetes.

Suggested Citation

  • An Na Kim & Hyun Jeong Cho & Jiyoung Youn & Taiyue Jin & Moonil Kang & Joohon Sung & Jung Eun Lee, 2020. "Coffee Consumption, Genetic Polymorphisms, and the Risk of Type 2 Diabetes Mellitus: A Pooled Analysis of Four Prospective Cohort Studies," IJERPH, MDPI, vol. 17(15), pages 1-18, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:15:p:5379-:d:390049
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    References listed on IDEAS

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    1. Yutian Yin & Weiqing Han & Yuhan Wang & Yue Zhang & Shili Wu & Huiping Zhang & Lingling Jiang & Rui Wang & Peng Zhang & Yaqin Yu & Bo Li, 2015. "Identification of Risk Factors Affecting Impaired Fasting Glucose and Diabetes in Adult Patients from Northeast China," IJERPH, MDPI, vol. 12(10), pages 1-17, October.
    2. Tara Kelly & David Unwin & Francis Finucane, 2020. "Low-Carbohydrate Diets in the Management of Obesity and Type 2 Diabetes: A Review from Clinicians Using the Approach in Practice," IJERPH, MDPI, vol. 17(7), pages 1-18, April.
    3. Denisa Margină & Anca Ungurianu & Carmen Purdel & Dimitris Tsoukalas & Evangelia Sarandi & Maria Thanasoula & Fotios Tekos & Robin Mesnage & Demetrios Kouretas & Aristidis Tsatsakis, 2020. "Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors," IJERPH, MDPI, vol. 17(11), pages 1-27, June.
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    Cited by:

    1. Ewa Czarniecka-Skubina & Marlena Pielak & Piotr Sałek & Renata Korzeniowska-Ginter & Tomasz Owczarek, 2021. "Consumer Choices and Habits Related to Coffee Consumption by Poles," IJERPH, MDPI, vol. 18(8), pages 1-21, April.

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