IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i2p511-d477765.html
   My bibliography  Save this article

Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders

Author

Listed:
  • Kaiser Wani

    (Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia)

  • Hind AlHarthi

    (Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia)

  • Amani Alghamdi

    (Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia)

  • Shaun Sabico

    (Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia)

  • Nasser M. Al-Daghri

    (Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia)

Abstract

NLRP3 inflammasome is one of the multimeric protein complexes of the nucleotide-binding domain, leucine-rich repeat (NLR)-containing pyrin and HIN domain family (PYHIN). When activated, NLRP3 inflammasome triggers the release of pro-inflammatory interleukins (IL)-1β and IL-18, an essential step in innate immune response; however, defective checkpoints in inflammasome activation may lead to autoimmune, autoinflammatory, and metabolic disorders. Among the consequences of NLRP3 inflammasome activation is systemic chronic low-grade inflammation, a cardinal feature of obesity and insulin resistance. Understanding the mechanisms involved in the regulation of NLRP3 inflammasome in adipose tissue may help in the development of specific inhibitors for the treatment and prevention of obesity-mediated metabolic diseases. In this narrative review, the current understanding of NLRP3 inflammasome activation and regulation is highlighted, including its putative roles in adipose tissue dysfunction and insulin resistance. Specific inhibitors of NLRP3 inflammasome activation which can potentially be used to treat metabolic disorders are also discussed.

Suggested Citation

  • Kaiser Wani & Hind AlHarthi & Amani Alghamdi & Shaun Sabico & Nasser M. Al-Daghri, 2021. "Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders," IJERPH, MDPI, vol. 18(2), pages 1-21, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:2:p:511-:d:477765
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/2/511/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/2/511/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Rongbin Zhou & Amir S. Yazdi & Philippe Menu & Jürg Tschopp, 2011. "A role for mitochondria in NLRP3 inflammasome activation," Nature, Nature, vol. 469(7329), pages 221-225, January.
    2. Rongbin Zhou & Amir S. Yazdi & Philippe Menu & Jürg Tschopp, 2011. "Erratum: A role for mitochondria in NLRP3 inflammasome activation," Nature, Nature, vol. 475(7354), pages 122-122, July.
    3. Min Xie & Yan Yu & Rui Kang & Shan Zhu & Liangchun Yang & Ling Zeng & Xiaofang Sun & Minghua Yang & Timothy R. Billiar & Haichao Wang & Lizhi Cao & Jianxin Jiang & Daolin Tang, 2016. "PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation," Nature Communications, Nature, vol. 7(1), pages 1-13, December.
    4. Peter Duewell & Hajime Kono & Katey J. Rayner & Cherilyn M. Sirois & Gregory Vladimer & Franz G. Bauernfeind & George S. Abela & Luigi Franchi & Gabriel Nuñez & Max Schnurr & Terje Espevik & Egil Lien, 2010. "NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals," Nature, Nature, vol. 464(7293), pages 1357-1361, April.
    5. Yuan He & Melody Y. Zeng & Dahai Yang & Benny Motro & Gabriel Núñez, 2016. "NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux," Nature, Nature, vol. 530(7590), pages 354-357, February.
    6. Peter Duewell & Hajime Kono & Katey J. Rayner & Cherilyn M. Sirois & Gregory Vladimer & Franz G. Bauernfeind & George S. Abela & Luigi Franchi & Gabriel Nuñez & Max Schnurr & Terje Espevik & Egil Lien, 2010. "Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals," Nature, Nature, vol. 466(7306), pages 652-652, July.
    7. Ben Lu & Takahisa Nakamura & Karen Inouye & Jianhua Li & Yiting Tang & Peter Lundbäck & Sergio I. Valdes-Ferrer & Peder S. Olofsson & Thomas Kalb & Jesse Roth & Yongrui Zou & Helena Erlandsson-Harris , 2012. "Novel role of PKR in inflammasome activation and HMGB1 release," Nature, Nature, vol. 488(7413), pages 670-674, August.
    8. Irsan E Kooi & Berber M Mol & Maarten P G Massink & Marcus C de Jong & Pim de Graaf & Paul van der Valk & Hanne Meijers-Heijboer & Gertjan J L Kaspers & Annette C Moll & Hein te Riele & Jacqueline Clo, 2016. "A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-20, April.
    9. Fiachra Humphries & Ronan Bergin & Ruaidhri Jackson & Nezira Delagic & Bingwei Wang & Shuo Yang & Alice V. Dubois & Rebecca J. Ingram & Paul N. Moynagh, 2018. "The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    10. Jorge Henao-Mejia & Eran Elinav & Chengcheng Jin & Liming Hao & Wajahat Z. Mehal & Till Strowig & Christoph A. Thaiss & Andrew L. Kau & Stephanie C. Eisenbarth & Michael J. Jurczak & Joao-Paulo Campor, 2012. "Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity," Nature, Nature, vol. 482(7384), pages 179-185, February.
    11. Christina D. Camell & Jil Sander & Olga Spadaro & Aileen Lee & Kim Y. Nguyen & Allison Wing & Emily L. Goldberg & Yun-Hee Youm & Chester W. Brown & John Elsworth & Matthew S. Rodeheffer & Joachim L. S, 2017. "Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing," Nature, Nature, vol. 550(7674), pages 119-123, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Antti J. Koivisto & Jaana E. Palomäki & Anna-Kaisa Viitanen & Kirsi M. Siivola & Ismo K. Koponen & Mingzhou Yu & Tomi S. Kanerva & Hannu Norppa & Harri T. Alenius & Tareq Hussein & Kai M. Savolainen &, 2014. "Range-Finding Risk Assessment of Inhalation Exposure to Nanodiamonds in a Laboratory Environment," IJERPH, MDPI, vol. 11(5), pages 1-21, May.
    2. Simona Pisanti & Erika Rimondi & Elena Pozza & Elisabetta Melloni & Enrico Zauli & Maurizio Bifulco & Rosanna Martinelli & Annalisa Marcuzzi, 2022. "Prenylation Defects and Oxidative Stress Trigger the Main Consequences of Neuroinflammation Linked to Mevalonate Pathway Deregulation," IJERPH, MDPI, vol. 19(15), pages 1-15, July.
    3. Chang Liu & Yaohui Zhu & Zhenxiang Lu & Weina Guo & Bayaer Tumen & Yalan He & Chao Chen & Shanshan Hu & Kangzhi Xu & Yan Wang & Lei Li & Shenghe Li, 2019. "Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway," IJERPH, MDPI, vol. 17(1), pages 1-10, December.
    4. Yening Zhang & Ling Luo & Xueming Xu & Jianfeng Wu & Fupeng Wang & Yanyan Lu & Ningjie Zhang & Yingying Ding & Ben Lu & Kai Zhao, 2023. "Acetylation is required for full activation of the NLRP3 inflammasome," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    5. Jakob Hartmann & Thomas Bajaj & Joy Otten & Claudia Klengel & Tim Ebert & Anne-Kathrin Gellner & Ellen Junglas & Kathrin Hafner & Elmira A. Anderzhanova & Fiona Tang & Galen Missig & Lindsay Rexrode &, 2024. "SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    6. Jukka Hintikka & Sanna Lensu & Elina Mäkinen & Sira Karvinen & Marjaana Honkanen & Jere Lindén & Tim Garrels & Satu Pekkala & Leo Lahti, 2021. "Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation: Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering," IJERPH, MDPI, vol. 18(8), pages 1-24, April.
    7. Xiaodi Yu & Rosalie E. Matico & Robyn Miller & Dhruv Chauhan & Bertrand Schoubroeck & Karolien Grauwen & Javier Suarez & Beth Pietrak & Nandan Haloi & Yanting Yin & Gary John Tresadern & Laura Perez-B, 2024. "Structural basis for the oligomerization-facilitated NLRP3 activation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    8. Tingting Niu & Charlotte Rosny & Séverine Chautard & Amaury Rey & Danish Patoli & Marine Groslambert & Camille Cosson & Brice Lagrange & Zhirong Zhang & Orane Visvikis & Sabine Hacot & Maggy Hologne &, 2021. "NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    9. Danfeng Dong & Yuzhang Du & Xuefeng Fei & Hao Yang & Xiaofang Li & Xiaobao Yang & Junrui Ma & Shu Huang & Zhihui Ma & Juanjuan Zheng & David W. Chan & Liyun Shi & Yunqi Li & Aaron T. Irving & Xianglia, 2023. "Inflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:2:p:511-:d:477765. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.