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Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

Author

Listed:
  • Christina D. Camell

    (Yale School of Medicine
    Yale School of Medicine)

  • Jil Sander

    (Genomics and Immunoregulation, LIMES-Institute, University of Bonn)

  • Olga Spadaro

    (Yale School of Medicine
    Yale School of Medicine)

  • Aileen Lee

    (Yale School of Medicine
    Yale School of Medicine)

  • Kim Y. Nguyen

    (Yale School of Medicine
    Yale School of Medicine)

  • Allison Wing

    (Cellular and Developmental Biology, Yale School of Medicine)

  • Emily L. Goldberg

    (Yale School of Medicine
    Yale School of Medicine)

  • Yun-Hee Youm

    (Yale School of Medicine
    Yale School of Medicine)

  • Chester W. Brown

    (University of Tennessee Health Science Center)

  • John Elsworth

    (Yale School of Medicine)

  • Matthew S. Rodeheffer

    (Yale School of Medicine)

  • Joachim L. Schultze

    (Genomics and Immunoregulation, LIMES-Institute, University of Bonn
    Single Cell Genomics and Epigenomics Unit at the University of Bonn and the German Center for Neurodegenerative Diseases)

  • Vishwa Deep Dixit

    (Yale School of Medicine
    Yale School of Medicine
    Yale Center for Research on Aging, Yale School of Medicine)

Abstract

Lipolysis declines with age because NLRP3 inflammasome-activated adipose tissue macrophages reduce levels of noradrenaline by upregulating genes that control its degradation, such as GDF3 and MAOA.

Suggested Citation

  • Christina D. Camell & Jil Sander & Olga Spadaro & Aileen Lee & Kim Y. Nguyen & Allison Wing & Emily L. Goldberg & Yun-Hee Youm & Chester W. Brown & John Elsworth & Matthew S. Rodeheffer & Joachim L. S, 2017. "Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing," Nature, Nature, vol. 550(7674), pages 119-123, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7674:d:10.1038_nature24022
    DOI: 10.1038/nature24022
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    Cited by:

    1. Kaiser Wani & Hind AlHarthi & Amani Alghamdi & Shaun Sabico & Nasser M. Al-Daghri, 2021. "Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders," IJERPH, MDPI, vol. 18(2), pages 1-21, January.

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