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A role for mitochondria in NLRP3 inflammasome activation

Author

Listed:
  • Rongbin Zhou

    (Center of Immunity and Infection, University of Lausanne)

  • Amir S. Yazdi

    (Center of Immunity and Infection, University of Lausanne)

  • Philippe Menu

    (Center of Immunity and Infection, University of Lausanne)

  • Jürg Tschopp

    (Center of Immunity and Infection, University of Lausanne)

Abstract

Mitochondrial role in inflammation The NLRP3 inflammasome is a molecular complex that triggers innate immune defences through the maturation of pro-inflammatory cytokines such as interleukin-1β, in response to danger signals such as infection and metabolic dysregulation. Tschopp and colleagues now report an unexpected central role for mitochondria in the process. The NLRP3 inflammasomes are activated by the reactive oxygen species released by damaged mitochondria. This work suggests that mitochondria are not only essential for apoptosis but also for an inflammatory response.

Suggested Citation

  • Rongbin Zhou & Amir S. Yazdi & Philippe Menu & Jürg Tschopp, 2011. "A role for mitochondria in NLRP3 inflammasome activation," Nature, Nature, vol. 469(7329), pages 221-225, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7329:d:10.1038_nature09663
    DOI: 10.1038/nature09663
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    Cited by:

    1. Kaiser Wani & Hind AlHarthi & Amani Alghamdi & Shaun Sabico & Nasser M. Al-Daghri, 2021. "Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders," IJERPH, MDPI, vol. 18(2), pages 1-21, January.
    2. Simona Pisanti & Erika Rimondi & Elena Pozza & Elisabetta Melloni & Enrico Zauli & Maurizio Bifulco & Rosanna Martinelli & Annalisa Marcuzzi, 2022. "Prenylation Defects and Oxidative Stress Trigger the Main Consequences of Neuroinflammation Linked to Mevalonate Pathway Deregulation," IJERPH, MDPI, vol. 19(15), pages 1-15, July.
    3. Chang Liu & Yaohui Zhu & Zhenxiang Lu & Weina Guo & Bayaer Tumen & Yalan He & Chao Chen & Shanshan Hu & Kangzhi Xu & Yan Wang & Lei Li & Shenghe Li, 2019. "Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway," IJERPH, MDPI, vol. 17(1), pages 1-10, December.

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