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Novel role of PKR in inflammasome activation and HMGB1 release

Author

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  • Ben Lu

    (Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    The Elmezzi Graduate School of Molecular Medicine, North Shore-LIJ Health system, 350 Community Drive, Manhasset, New York 11030, USA)

  • Takahisa Nakamura

    (Harvard School of Public Health)

  • Karen Inouye

    (Harvard School of Public Health)

  • Jianhua Li

    (Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA)

  • Yiting Tang

    (Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, New York, New York 11030, USA)

  • Peter Lundbäck

    (Karolinska Institute, Karolinska University Hospital, Stockholm S-17176, Sweden)

  • Sergio I. Valdes-Ferrer

    (Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    The Elmezzi Graduate School of Molecular Medicine, North Shore-LIJ Health system, 350 Community Drive, Manhasset, New York 11030, USA)

  • Peder S. Olofsson

    (Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA)

  • Thomas Kalb

    (Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA)

  • Jesse Roth

    (Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA)

  • Yongrui Zou

    (Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, New York, New York 11030, USA)

  • Helena Erlandsson-Harris

    (Karolinska Institute, Karolinska University Hospital, Stockholm S-17176, Sweden)

  • Huan Yang

    (Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA)

  • Jenny P.-Y. Ting

    (University of North Carolina at Chapel Hill)

  • Haichao Wang

    (North Shore University Hospital)

  • Ulf Andersson

    (Women’s and Children’s Health, Karolinska Institute, Karolinska University Hospital, Stockholm S-17176, Sweden)

  • Daniel J. Antoine

    (MRC Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE, UK)

  • Sangeeta S. Chavan

    (Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA)

  • Gökhan S. Hotamisligil

    (Harvard School of Public Health)

  • Kevin J. Tracey

    (Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    The Elmezzi Graduate School of Molecular Medicine, North Shore-LIJ Health system, 350 Community Drive, Manhasset, New York 11030, USA)

Abstract

Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release of interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1) in response to a diverse range of stimuli.

Suggested Citation

  • Ben Lu & Takahisa Nakamura & Karen Inouye & Jianhua Li & Yiting Tang & Peter Lundbäck & Sergio I. Valdes-Ferrer & Peder S. Olofsson & Thomas Kalb & Jesse Roth & Yongrui Zou & Helena Erlandsson-Harris , 2012. "Novel role of PKR in inflammasome activation and HMGB1 release," Nature, Nature, vol. 488(7413), pages 670-674, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7413:d:10.1038_nature11290
    DOI: 10.1038/nature11290
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    Cited by:

    1. Kaiser Wani & Hind AlHarthi & Amani Alghamdi & Shaun Sabico & Nasser M. Al-Daghri, 2021. "Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders," IJERPH, MDPI, vol. 18(2), pages 1-21, January.

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