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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Author

Listed:
  • Peter Duewell

    (Department of Infectious Diseases and Immunology and,
    University of Munich)

  • Hajime Kono

    (University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

  • Katey J. Rayner

    (New York University, New York, New York 10016, USA
    Harvard Medical School, Lipid Metabolism Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA)

  • Cherilyn M. Sirois

    (Department of Infectious Diseases and Immunology and,)

  • Gregory Vladimer

    (Department of Infectious Diseases and Immunology and,)

  • Franz G. Bauernfeind

    (Institute of Clinical Chemistry and Pharmacology and,)

  • George S. Abela

    (Michigan State University, East Lansing, Michigan 48824, USA)

  • Luigi Franchi

    (University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Gabriel Nuñez

    (University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Max Schnurr

    (University of Munich)

  • Terje Espevik

    (Institute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, 7491, Norway)

  • Egil Lien

    (Department of Infectious Diseases and Immunology and,)

  • Katherine A. Fitzgerald

    (Department of Infectious Diseases and Immunology and,)

  • Kenneth L. Rock

    (University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

  • Kathryn J. Moore

    (New York University, New York, New York 10016, USA
    Harvard Medical School, Lipid Metabolism Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA)

  • Samuel D. Wright

    (Cardiovascular Therapeutics, CSL Limited, Parkville, Victoria 3052, Australia)

  • Veit Hornung

    (Harvard Medical School, Lipid Metabolism Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA)

  • Eicke Latz

    (Department of Infectious Diseases and Immunology and,
    Institute of Innate Immunology, University Hospitals, University of Bonn, 53127 Bonn, Germany
    Institute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, 7491, Norway)

Abstract

Cholesterol crystals cleared A study in atherosclerosis-prone (apolipoprotein E-deficient) mice on a high cholesterol diet shows that small cholesterol crystals appear in the earliest stages of atherogenesis, and that these crystals can activate the NLRP3 inflammasome in phagocytes. This suggests that therapeutic strategies that reduce cholesterol crystal deposition or block the inflammasome pathway may have anti-atherosclerotic activity.

Suggested Citation

  • Peter Duewell & Hajime Kono & Katey J. Rayner & Cherilyn M. Sirois & Gregory Vladimer & Franz G. Bauernfeind & George S. Abela & Luigi Franchi & Gabriel Nuñez & Max Schnurr & Terje Espevik & Egil Lien, 2010. "NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals," Nature, Nature, vol. 464(7293), pages 1357-1361, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7293:d:10.1038_nature08938
    DOI: 10.1038/nature08938
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    Cited by:

    1. Antti J. Koivisto & Jaana E. Palomäki & Anna-Kaisa Viitanen & Kirsi M. Siivola & Ismo K. Koponen & Mingzhou Yu & Tomi S. Kanerva & Hannu Norppa & Harri T. Alenius & Tareq Hussein & Kai M. Savolainen &, 2014. "Range-Finding Risk Assessment of Inhalation Exposure to Nanodiamonds in a Laboratory Environment," IJERPH, MDPI, vol. 11(5), pages 1-21, May.
    2. Kaiser Wani & Hind AlHarthi & Amani Alghamdi & Shaun Sabico & Nasser M. Al-Daghri, 2021. "Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders," IJERPH, MDPI, vol. 18(2), pages 1-21, January.

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