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NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

Author

Listed:
  • Yuan He

    (University of Michigan Medical School)

  • Melody Y. Zeng

    (University of Michigan Medical School)

  • Dahai Yang

    (University of Michigan Medical School
    The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology)

  • Benny Motro

    (The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University)

  • Gabriel Núñez

    (University of Michigan Medical School)

Abstract

NEK7, a member of the NIMA-related kinase family, is identified as a regulator of NLRP3 inflammasome oligomerization and activation; NEK7 functions downstream of potassium efflux in a manner that is independent of its kinase activity.

Suggested Citation

  • Yuan He & Melody Y. Zeng & Dahai Yang & Benny Motro & Gabriel Núñez, 2016. "NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux," Nature, Nature, vol. 530(7590), pages 354-357, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7590:d:10.1038_nature16959
    DOI: 10.1038/nature16959
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    Cited by:

    1. Yening Zhang & Ling Luo & Xueming Xu & Jianfeng Wu & Fupeng Wang & Yanyan Lu & Ningjie Zhang & Yingying Ding & Ben Lu & Kai Zhao, 2023. "Acetylation is required for full activation of the NLRP3 inflammasome," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Kaiser Wani & Hind AlHarthi & Amani Alghamdi & Shaun Sabico & Nasser M. Al-Daghri, 2021. "Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders," IJERPH, MDPI, vol. 18(2), pages 1-21, January.
    3. Danfeng Dong & Yuzhang Du & Xuefeng Fei & Hao Yang & Xiaofang Li & Xiaobao Yang & Junrui Ma & Shu Huang & Zhihui Ma & Juanjuan Zheng & David W. Chan & Liyun Shi & Yunqi Li & Aaron T. Irving & Xianglia, 2023. "Inflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Xiaodi Yu & Rosalie E. Matico & Robyn Miller & Dhruv Chauhan & Bertrand Schoubroeck & Karolien Grauwen & Javier Suarez & Beth Pietrak & Nandan Haloi & Yanting Yin & Gary John Tresadern & Laura Perez-B, 2024. "Structural basis for the oligomerization-facilitated NLRP3 activation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Jakob Hartmann & Thomas Bajaj & Joy Otten & Claudia Klengel & Tim Ebert & Anne-Kathrin Gellner & Ellen Junglas & Kathrin Hafner & Elmira A. Anderzhanova & Fiona Tang & Galen Missig & Lindsay Rexrode &, 2024. "SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    6. Tingting Niu & Charlotte Rosny & Séverine Chautard & Amaury Rey & Danish Patoli & Marine Groslambert & Camille Cosson & Brice Lagrange & Zhirong Zhang & Orane Visvikis & Sabine Hacot & Maggy Hologne &, 2021. "NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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