IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i15p9061-d871374.html
   My bibliography  Save this article

Prenylation Defects and Oxidative Stress Trigger the Main Consequences of Neuroinflammation Linked to Mevalonate Pathway Deregulation

Author

Listed:
  • Simona Pisanti

    (Department of Medicine, Surgery and Dentistry ′Scuola Medica Salernitana′, University of Salerno, 84081 Baronissi, Italy)

  • Erika Rimondi

    (Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy
    LTTA Centre, University of Ferrara, 44121 Ferrara, Italy)

  • Elena Pozza

    (Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy)

  • Elisabetta Melloni

    (Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy
    LTTA Centre, University of Ferrara, 44121 Ferrara, Italy)

  • Enrico Zauli

    (Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy)

  • Maurizio Bifulco

    (Department of Molecular Medicine and Medical Biotechnologies, University of Naples “Federico II”, 80131 Naples, Italy)

  • Rosanna Martinelli

    (Department of Medicine, Surgery and Dentistry ′Scuola Medica Salernitana′, University of Salerno, 84081 Baronissi, Italy)

  • Annalisa Marcuzzi

    (Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy)

Abstract

The cholesterol biosynthesis represents a crucial metabolic pathway for cellular homeostasis. The end products of this pathway are sterols, such as cholesterol, which are essential components of cell membranes, precursors of steroid hormones, bile acids, and other molecules such as ubiquinone. Furthermore, some intermediates of this metabolic system perform biological activity in specific cellular compartments, such as isoprenoid molecules that can modulate different signal proteins through the prenylation process. The defects of prenylation represent one of the main causes that promote the activation of inflammation. In particular, this mechanism, in association with oxidative stress, induces a dysfunction of the mitochondrial activity. The purpose of this review is to describe the pleiotropic role of prenylation in neuroinflammation and to highlight the consequence of the defects of prenylation.

Suggested Citation

  • Simona Pisanti & Erika Rimondi & Elena Pozza & Elisabetta Melloni & Enrico Zauli & Maurizio Bifulco & Rosanna Martinelli & Annalisa Marcuzzi, 2022. "Prenylation Defects and Oxidative Stress Trigger the Main Consequences of Neuroinflammation Linked to Mevalonate Pathway Deregulation," IJERPH, MDPI, vol. 19(15), pages 1-15, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9061-:d:871374
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/15/9061/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/15/9061/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Rongbin Zhou & Amir S. Yazdi & Philippe Menu & Jürg Tschopp, 2011. "A role for mitochondria in NLRP3 inflammasome activation," Nature, Nature, vol. 469(7329), pages 221-225, January.
    2. Rongbin Zhou & Amir S. Yazdi & Philippe Menu & Jürg Tschopp, 2011. "Erratum: A role for mitochondria in NLRP3 inflammasome activation," Nature, Nature, vol. 475(7354), pages 122-122, July.
    3. Abigail Watterson & Lexus Tatge & Naureen Wajahat & Sonja L. B. Arneaud & Rene Solano Fonseca & Shaghayegh T. Beheshti & Patrick Metang & Melina Mihelakis & Kielen R. Zuurbier & Chase D. Corley & Ishm, 2022. "Intracellular lipid surveillance by small G protein geranylgeranylation," Nature, Nature, vol. 605(7911), pages 736-740, May.
    4. Jing Chen & Xiaochen Zhang & Liping Li & Xianqiang Ma & Chunxiao Yang & Zhaodi Liu & Chenyang Li & Maria J Fernandez-Cabezudo & Basel K al-Ramadi & Chuan Wu & Weishan Huang & Yong Zhang & Yonghui Zhan, 2021. "Farnesyl pyrophosphate is a new danger signal inducing acute cell death," PLOS Biology, Public Library of Science, vol. 19(4), pages 1-25, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kaiser Wani & Hind AlHarthi & Amani Alghamdi & Shaun Sabico & Nasser M. Al-Daghri, 2021. "Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders," IJERPH, MDPI, vol. 18(2), pages 1-21, January.
    2. Chang Liu & Yaohui Zhu & Zhenxiang Lu & Weina Guo & Bayaer Tumen & Yalan He & Chao Chen & Shanshan Hu & Kangzhi Xu & Yan Wang & Lei Li & Shenghe Li, 2019. "Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway," IJERPH, MDPI, vol. 17(1), pages 1-10, December.
    3. Menghao Zhang & Na Kang & Xin Yu & Xiaoyang Zhang & Qinghui Duan & Xianqiang Ma & Qiancheng Zhao & Zhimian Wang & Xiao’ou Wang & Yeling Liu & Yuxiao Zhang & Can Zhu & Ruiyu Gao & Xin Min & Cuifeng Li , 2024. "TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Annmary Paul Erinjeri & Xunyan Wang & Rhianna Williams & Riccardo Zenezini Chiozzi & Konstantinos Thalassinos & Johnathan Labbadia, 2024. "HSF-1 promotes longevity through ubiquilin-1-dependent mitochondrial network remodelling," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9061-:d:871374. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.