IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i16p8833-d619167.html
   My bibliography  Save this article

Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women?

Author

Listed:
  • Salvatore Raimondo

    (“Gentile s.a.s.” Research Center, 80054 Gragnano, Italy)

  • Mariacira Gentile

    (“Gentile s.a.s.” Research Center, 80054 Gragnano, Italy)

  • Giusy Esposito

    (“Gentile s.a.s.” Research Center, 80054 Gragnano, Italy)

  • Tommaso Gentile

    (“Gentile s.a.s.” Research Center, 80054 Gragnano, Italy)

  • Ida Ferrara

    (Medical Center “Gunè”, 80011 Acerra, Italy)

  • Claudia Crescenzo

    (Clinic Center “HERA”, 80014 Giugliano, Italy)

  • Mariangela Palmieri

    (Clinic Center “HERA”, 80014 Giugliano, Italy)

  • Felice Cuomo

    (“Gentile s.a.s.” Research Center, 80054 Gragnano, Italy)

  • Stefania De Filippo

    (“Gentile s.a.s.” Research Center, 80054 Gragnano, Italy)

  • Gennaro Lettieri

    (Department of Biology, University of Naples Federico II, 80126 Naples, Italy)

  • Marina Piscopo

    (Department of Biology, University of Naples Federico II, 80126 Naples, Italy)

  • Luigi Montano

    (Andrology Unit and Service of Lifestyle Medicine in UroAndrology, Local Health Authority (ASL) Salerno, Coordination Unit of the network for Environmental and Reproductive Health (Eco-FoodFertility Project), “Ospedale San Francesco D’Assisi”, Oliveto Citra, 84020 Salerni, Italy
    PhD Program in Evolutionary Biology and Ecology, University of Rome “Tor Vergata”, 00133 Rome, Italy)

Abstract

Bisphenols and phthalates affect androgen receptor-mediated signaling that directly regulates Kallikrein-Related serine Peptidase 3 (KLK3) secretion, indicating that environmental factors may play a role in KLK3 secretion. With the aim of obtaining preliminary data on whether KLK3 could serve as an early marker of environmental pollution effects, in 61 and 58 healthy women living in a high environmental impact (HEI) and low environmental impact (LEI) area, respectively, serum KLK3 levels at different phases of menstrual cycle were measured. KLK3 values resulted in always being higher in the HEI group with respect to the LEI group. These differences were particularly relevant in the ovulatory phase (cycle day 12°–13°) of the menstrual cycle. The differences in KLK3 values during the three phases of the menstrual cycle were significant in the LEI group differently from the HEI group. In addition, higher progesterone levels were observed in the LEI group with respect to the HEI group in the luteal phase, indicating an opposite trend of KLK3 and progesterone in this phase of the menstrual cycle. Although changes in KLK3 could also depend on other factors, these preliminary data could be an early indication of an expanding study of the role of biomarkers in assessing early environmental effects for female reproductive health.

Suggested Citation

  • Salvatore Raimondo & Mariacira Gentile & Giusy Esposito & Tommaso Gentile & Ida Ferrara & Claudia Crescenzo & Mariangela Palmieri & Felice Cuomo & Stefania De Filippo & Gennaro Lettieri & Marina Pisco, 2021. "Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women?," IJERPH, MDPI, vol. 18(16), pages 1-15, August.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8833-:d:619167
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/16/8833/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/16/8833/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Alfredo Mazza & Prisco Piscitelli & Andrea Falco & Maria Lucia Santoro & Manuela Colangelo & Giovanni Imbriani & Adele Idolo & Antonella De Donno & Leopoldo Iannuzzi & Annamaria Colao, 2018. "Heavy Environmental Pressure in Campania and Other Italian Regions: A Short Review of Available Evidence," IJERPH, MDPI, vol. 15(1), pages 1-12, January.
    2. Luigi Montano & Francesco Donato & Pietro Massimiliano Bianco & Gennaro Lettieri & Antonino Guglielmino & Oriana Motta & Ian Marc Bonapace & Marina Piscopo, 2021. "Air Pollution and COVID-19: A Possible Dangerous Synergy for Male Fertility," IJERPH, MDPI, vol. 18(13), pages 1-21, June.
    3. Giuseppe Genchi & Maria Stefania Sinicropi & Graziantonio Lauria & Alessia Carocci & Alessia Catalano, 2020. "The Effects of Cadmium Toxicity," IJERPH, MDPI, vol. 17(11), pages 1-24, May.
    4. Anna Merklinger-Gruchala & Grazyna Jasienska & Maria Kapiszewska, 2017. "Effect of Air Pollution on Menstrual Cycle Length—A Prognostic Factor of Women’s Reproductive Health," IJERPH, MDPI, vol. 14(7), pages 1-17, July.
    5. Alfredo Mazza & Prisco Piscitelli & Cosimo Neglia & Giulia Della Rosa & Leopoldo Iannuzzi, 2015. "Illegal Dumping of Toxic Waste and Its Effect on Human Health in Campania, Italy," IJERPH, MDPI, vol. 12(6), pages 1-14, June.
    6. Cezary Wojtyla & Karolina Zielinska & Paulina Wojtyla-Buciora & Grzegorz Panek, 2020. "Prenatal Fine Particulate Matter (PM 2.5 ) Exposure and Pregnancy Outcomes—Analysis of Term Pregnancies in Poland," IJERPH, MDPI, vol. 17(16), pages 1-9, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alessandra Gallo, 2022. "Reprotoxic Impact of Environment, Diet, and Behavior," IJERPH, MDPI, vol. 19(3), pages 1-20, January.
    2. Pasquale Perrone & Gennaro Lettieri & Carmela Marinaro & Valentina Longo & Simonetta Capone & Angiola Forleo & Sebastiana Pappalardo & Luigi Montano & Marina Piscopo, 2022. "Molecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the “Valley of Sacco River” (Latium, Italy): A Preliminary Study," IJERPH, MDPI, vol. 19(17), pages 1-18, September.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Alfredo Mazza & Prisco Piscitelli & Andrea Falco & Maria Lucia Santoro & Manuela Colangelo & Giovanni Imbriani & Adele Idolo & Antonella De Donno & Leopoldo Iannuzzi & Annamaria Colao, 2018. "Heavy Environmental Pressure in Campania and Other Italian Regions: A Short Review of Available Evidence," IJERPH, MDPI, vol. 15(1), pages 1-12, January.
    2. Abhishek Nandan & Albin C. Suresh & Parth Saole & S. Amulya Jeevanasai & Ramprasad Chandrasekaran & Lucas Meili & Nur Izyan Wan Azelee & Rangabhashiyam Selvasembian, 2023. "An Integrated Approach for Electronic Waste Management—Overview of Sources of Generation, Toxicological Effects, Assessment, Governance, and Mitigation Approaches," Sustainability, MDPI, vol. 15(24), pages 1-19, December.
    3. Cristine Couto de Almeida & Diego dos Santos Baião & Paloma de Almeida Rodrigues & Tatiana Dillenburg Saint’Pierre & Rachel Ann Hauser-Davis & Katia Christina Leandro & Vania Margaret Flosi Paschoalin, 2022. "Toxic Metals and Metalloids in Infant Formulas Marketed in Brazil, and Child Health Risks According to the Target Hazard Quotients and Target Cancer Risk," IJERPH, MDPI, vol. 19(18), pages 1-14, September.
    4. Esin Dadasoglu & Melek Ekinci & Metin Turan & Ertan Yildirim, 2022. "Ameliorative Effects of Biochar for Cadmium Stress on Bean ( Phaseolus vulgaris L.) Growth," Sustainability, MDPI, vol. 14(23), pages 1-13, November.
    5. Laura A. Rodriguez-Villamizar & Olga M. Medina & Oscar Flórez-Vargas & Eugenio Vilanova & Alvaro J. Idrovo & Santiago A. Araque-Rodriguez & José A. Henao & Luz H. Sánchez-Rodríguez, 2023. "Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia," IJERPH, MDPI, vol. 20(3), pages 1-15, January.
    6. Eda Puntarić & Lato Pezo & Željka Zgorelec & Jerko Gunjača & Dajana Kučić Grgić & Neven Voća, 2022. "Prediction of the Production of Separated Municipal Solid Waste by Artificial Neural Networks in Croatia and the European Union," Sustainability, MDPI, vol. 14(16), pages 1-13, August.
    7. Annamaria Colao & Giovanna Muscogiuri & Prisco Piscitelli, 2016. "Environment and Health: Not Only Cancer," IJERPH, MDPI, vol. 13(7), pages 1-9, July.
    8. Anthony Milki & Deanna Wong & Chloe Chan & Sarita Sooklal & Daniel S. Kapp & Amandeep K. Mann, 2022. "Increased Urinary Cadmium Levels in Foreign-Born Asian Women—An NHANES Study of 9639 U.S. Participants," IJERPH, MDPI, vol. 19(4), pages 1-10, February.
    9. Maria Dettwiler & Angela C. Flynn & Jessica Rigutto-Farebrother, 2023. "Effects of Non-Essential “Toxic” Trace Elements on Pregnancy Outcomes: A Narrative Overview of Recent Literature Syntheses," IJERPH, MDPI, vol. 20(8), pages 1-16, April.
    10. Rattawan Somporn & Natcha Chaiwong & Mehedi Mahmudul Hasan & Sanhawat Chaiwong, 2023. "Cadmium Exposure and Renal Function Biomarkers: A 10-Year Follow-Up of Thailand’s Tak Province Population," Sustainability, MDPI, vol. 15(14), pages 1-18, July.
    11. Martyna A. Rzetala & Robert Machowski & Maksymilian Solarski & Daniel Bakota & Arkadiusz Płomiński & Mariusz Rzetala, 2023. "Toxic Metals, Non-Metals and Metalloids in Bottom Sediments as a Geoecological Indicator of a Water Body’s Suitability for Recreational Use," IJERPH, MDPI, vol. 20(5), pages 1-23, February.
    12. Mohineeta Pandey & Astha Tirkey & Ankesh Tiwari & Sang Soo Lee & Rashmi Dubey & Ki Hyun Kim & Sudhir Kumar Pandey, 2022. "The Environmental Significance of Contaminants of Concern in the Soil–Vegetable Interface: Sources, Accumulation, Health Risks, and Mitigation through Biochar," Sustainability, MDPI, vol. 14(21), pages 1-23, November.
    13. Carlos Tadashi Kunioka & Maria Conceição Manso & Márcia Carvalho, 2022. "Association between Environmental Cadmium Exposure and Osteoporosis Risk in Postmenopausal Women: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 20(1), pages 1-15, December.
    14. Haomin Lei & Xin Xu & Xiaofeng Liu & Junboum Park & Zhongyu Yu & Hao Liu, 2022. "Red Mud-Amended Soil as Highly Adsorptive Hybrid-Fill Materials for Controlling Heavy Metal Sewage Seepage in Industrial Zone," IJERPH, MDPI, vol. 19(22), pages 1-15, November.
    15. Anirban Goutam Mukherjee & Kaviyarasi Renu & Abilash Valsala Gopalakrishnan & Vishnu Priya Veeraraghavan & Sathishkumar Vinayagam & Soraya Paz-Montelongo & Abhijit Dey & Balachandar Vellingiri & Alex , 2023. "Heavy Metal and Metalloid Contamination in Food and Emerging Technologies for Its Detection," Sustainability, MDPI, vol. 15(2), pages 1-30, January.
    16. Pasquale Perrone & Gennaro Lettieri & Carmela Marinaro & Valentina Longo & Simonetta Capone & Angiola Forleo & Sebastiana Pappalardo & Luigi Montano & Marina Piscopo, 2022. "Molecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the “Valley of Sacco River” (Latium, Italy): A Preliminary Study," IJERPH, MDPI, vol. 19(17), pages 1-18, September.
    17. Alejandra Rodríguez-Fernández & Natalia Ramos-Castillo & Marcela Ruiz-De la Fuente & Julio Parra-Flores & Eduard Maury-Sintjago, 2022. "Association of Prematurity and Low Birth Weight with Gestational Exposure to PM 2.5 and PM 10 Particulate Matter in Chileans Newborns," IJERPH, MDPI, vol. 19(10), pages 1-5, May.
    18. Żaneta Ciosek & Karolina Kot & Iwona Rotter, 2023. "Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue," IJERPH, MDPI, vol. 20(3), pages 1-25, January.
    19. Soisungwan Satarug & David A. Vesey & Glenda C. Gobe, 2022. "Dose–Response Analysis of the Tubular and Glomerular Effects of Chronic Exposure to Environmental Cadmium," IJERPH, MDPI, vol. 19(17), pages 1-14, August.
    20. Iwona Markiewicz-Górka & Małgorzata Chowaniec & Helena Martynowicz & Anna Wojakowska & Aleksandra Jaremków & Grzegorz Mazur & Piotr Wiland & Krystyna Pawlas & Rafał Poręba & Paweł Gać, 2022. "Cadmium Body Burden and Inflammatory Arthritis: A Pilot Study in Patients from Lower Silesia, Poland," IJERPH, MDPI, vol. 19(5), pages 1-19, March.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8833-:d:619167. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.