IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i16p8552-d613786.html
   My bibliography  Save this article

The Impact of COVID-19 Pandemic in Portuguese Cancer Patients: A Retrospective Study

Author

Listed:
  • Aurea Lima

    (Centro Hospitalar de Entre o Douro e Vouga EPE, Medical Oncology Department, Unit of Santa Maria da Feira, Rua Dr. Cândido Pinho 5, 4520-211 Santa Maria da Feira, Portugal
    Research Center (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Porto Comprehensive Cancer Center (Porto.CCC), Molecular Oncology and Viral Pathology Group, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal
    Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Department of Pharmaceutical Sciences, Institute of Research and Advanced Training in Health Sciences and Technologies, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal)

  • Hugo Sousa

    (Research Center (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Porto Comprehensive Cancer Center (Porto.CCC), Molecular Oncology and Viral Pathology Group, Portuguese Oncology Institute of Porto (IPO Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal
    Virology Service, Portuguese Institute of Oncology of Porto (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal)

  • Amanda Nobre

    (Centro Hospitalar de Entre o Douro e Vouga EPE, Medical Oncology Department, Unit of Santa Maria da Feira, Rua Dr. Cândido Pinho 5, 4520-211 Santa Maria da Feira, Portugal)

  • Ana Luisa Faria

    (Centro Hospitalar de Entre o Douro e Vouga EPE, Medical Oncology Department, Unit of Santa Maria da Feira, Rua Dr. Cândido Pinho 5, 4520-211 Santa Maria da Feira, Portugal)

  • Manuela Machado

    (Centro Hospitalar de Entre o Douro e Vouga EPE, Medical Oncology Department, Unit of Santa Maria da Feira, Rua Dr. Cândido Pinho 5, 4520-211 Santa Maria da Feira, Portugal)

Abstract

Literature reports that SARS-CoV-2 infection in cancer patients may be associated with higher severity and mortality, nevertheless the knowledge is limited. We aimed to describe patients’ demographic characteristics and COVID-19 disease outcomes in Portuguese cancer patients. We conducted a retrospective study in a cohort of cancer patients diagnosed with COVID-19. A total of 127 individuals were included: 46.5% males and 53.5% females, with a median age of 72 years. Clinicopathological characteristics were used in univariate and multivariable logistic regression analyses to estimate odds ratios for each variable with outcomes adjusting for potential confounders. Our cohort revealed that 84.3% of patients had more than one risk factor for severe disease rather than cancer. In total, 36.2% of patients were admitted to the Department of Internal Medicine, 14.2% developed severe disease, 1.6% required Intensive Care Unit, and mortality was observed in 11.8%. Severe COVID-19 disease was associated with unfit (ECOG PS > 2) patients ( p = 0.009; OR = 6.39; 95% CI: 1.60–25.59), chronic kidney disease ( p = 0.004; OR = 20.7; 95% CI: 2.64–162.8), immunosuppression ( p < 0.001; OR = 10.3; 95% CI: 2.58–41.2), and presence of respiratory symptoms at diagnosis ( p = 0.033; OR = 5.05; 95% CI: 1.14–22.4). Increased risk for mortality was associated with unfit patients ( p = 0.036; OR = 4.22; 95% CI: 1.10–16.3), cardiac disease ( p = 0.003; OR = 8.26; 95% CI: 2.03–33.6) and immunosuppression ( p = 0.022; OR = 5.06; 95% CI: 1.27–20.18). Our results demonstrated that unfit and immunosuppressed patients, with chronic kidney disease and cardiac disease, have, respectively, an increased risk for severe disease and mortality related to COVID-19. Hence, this study provides important information on risk factors for severe COVID-19 disease and associated mortality in a Portuguese cancer population.

Suggested Citation

  • Aurea Lima & Hugo Sousa & Amanda Nobre & Ana Luisa Faria & Manuela Machado, 2021. "The Impact of COVID-19 Pandemic in Portuguese Cancer Patients: A Retrospective Study," IJERPH, MDPI, vol. 18(16), pages 1-15, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8552-:d:613786
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/16/8552/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/16/8552/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jaber S Alqahtani & Tope Oyelade & Abdulelah M Aldhahir & Saeed M Alghamdi & Mater Almehmadi & Abdullah S Alqahtani & Shumonta Quaderi & Swapna Mandal & John R Hurst, 2020. "Prevalence, Severity and Mortality associated with COPD and Smoking in patients with COVID-19: A Rapid Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-13, May.
    2. Qixin Yang & Xiyao Yang, 2020. "Incidence and risk factors of kidney impairment on patients with COVID-19: A meta-analysis of 10180 patients," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-13, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ning Zhang & Tao Xie & Wei Ning & Rongxin He & Bin Zhu & Ying Mao, 2021. "The Severity of COVID-19 and Its Determinants: A Systematic Review and Meta-Analysis in China," Sustainability, MDPI, vol. 13(9), pages 1-17, May.
    2. Dimitra Kale & Olga Perski & Aleksandra Herbec & Emma Beard & Lion Shahab, 2022. "Changes in Cigarette Smoking and Vaping in Response to the COVID-19 Pandemic in the UK: Findings from Baseline and 12-Month Follow up of HEBECO Study," IJERPH, MDPI, vol. 19(2), pages 1-16, January.
    3. Eugenia Lee & Stephanie Pike Moore & Erika Trapl & Craig S. Fryer & Douglas Gunzler & Kymberle L. Sterling, 2022. "Changes in Little Cigar and Cigarillo Use during the COVID-19 Pandemic: A Cross-Sectional Analysis of a Nationally Representative Sample of Young Adult Users," IJERPH, MDPI, vol. 19(15), pages 1-11, July.
    4. Holly L. Richmond & Joana Tome & Haresh Rochani & Isaac Chun-Hai Fung & Gulzar H. Shah & Jessica S. Schwind, 2020. "The Use of Penalized Regression Analysis to Identify County-Level Demographic and Socioeconomic Variables Predictive of Increased COVID-19 Cumulative Case Rates in the State of Georgia," IJERPH, MDPI, vol. 17(21), pages 1-12, October.
    5. Mariaelena Gonzalez & Anna E. Epperson & Bonnie Halpern-Felsher & Deanna M. Halliday & Anna V. Song, 2021. "Smokers Are More Likely to Smoke More after the COVID-19 California Lockdown Order," IJERPH, MDPI, vol. 18(5), pages 1-9, March.
    6. Irfan, Muhammad & Akram, Waqar & James Hooper, Vincent, 2020. "What factors can help COVID-19 patients to recover quickly in Pakistan," MPRA Paper 103053, University Library of Munich, Germany, revised 15 Sep 2020.
    7. Louisa L. Y. Chan & Danielle E. Anderson & Hong Sheng Cheng & Fransiskus Xaverius Ivan & Si Chen & Adrian E. Z. Kang & Randy Foo & Akshamal M. Gamage & Pei Yee Tiew & Mariko Siyue Koh & Ken Cheah Hooi, 2022. "The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    8. Juliana Rodrigues Tovar Garbin & Franciéle Marabotti Costa Leite & Luís Carlos Lopes-Júnior & Cristiano Soares da Silva Dell’Antonio & Larissa Soares Dell’Antonio & Ana Paula Brioschi dos Santos, 2022. "Analysis of Survival of Patients Hospitalized with COVID-19 in Espírito Santo, Brazil," IJERPH, MDPI, vol. 19(14), pages 1-16, July.
    9. Yirui Ma & Jie Deng & Qiao Liu & Min Du & Min Liu & Jue Liu, 2022. "Long-Term Consequences of COVID-19 at 6 Months and Above: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(11), pages 1-16, June.
    10. Veruscka Leso & Luca Fontana & Ivo Iavicoli, 2021. "Susceptibility to Coronavirus (COVID-19) in Occupational Settings: The Complex Interplay between Individual and Workplace Factors," IJERPH, MDPI, vol. 18(3), pages 1-16, January.
    11. Khurshid, Adnan & Chen, Yufeng & Rauf, Abdur & Khan, Khalid, 2023. "Critical metals in uncertainty: How Russia-Ukraine conflict drives their prices?," Resources Policy, Elsevier, vol. 85(PB).
    12. Tania Buttiron Webber & Silvia Giuliano & Carlotta Patrone & Irene Maria Briata & Maria Franconeri & Francesca Marceca & Monica Magnani & Fortuna Paciolla & Nicoletta Provinciali & Carlotta Defferrari, 2021. "Home Se-Cure: A Home Care Service for Cancer Patients during the COVID-19 Pandemic," IJERPH, MDPI, vol. 18(20), pages 1-8, October.
    13. Yoo Min Park & Gregory D. Kearney & Bennett Wall & Katherine Jones & Robert J. Howard & Ray H. Hylock, 2021. "COVID-19 Deaths in the United States: Shifts in Hot Spots over the Three Phases of the Pandemic and the Spatiotemporally Varying Impact of Pandemic Vulnerability," IJERPH, MDPI, vol. 18(17), pages 1-15, August.
    14. Rhys Hamon & Miranda P. Ween, 2022. "E-Cigarette Vapour Increases ACE2 and TMPRSS2 Expression in a Flavour- and Nicotine-Dependent Manner," IJERPH, MDPI, vol. 19(22), pages 1-12, November.
    15. Romain Guignard & Guillemette Quatremère & Anne Pasquereau & Cécile Jartoux & Laure Salvaing & Guillaume Caline & François Beck & Viêt Nguyen Thanh, 2022. "Barriers Against and Motivations for Quitting Smoking during the COVID-19 Health Crisis: Results of a Qualitative Study in France," IJERPH, MDPI, vol. 19(20), pages 1-11, October.
    16. Ejin Kim & Yong Chul Kim & Jae Yoon Park & Jiyun Jung & Jung Pyo Lee & Ho Kim, 2021. "Evaluation of the Prognosis of COVID-19 Patients According to the Presence of Underlying Diseases and Drug Treatment," IJERPH, MDPI, vol. 18(10), pages 1-14, May.
    17. Linh T. Bui & Nichelle I. Winters & Mei-I Chung & Chitra Joseph & Austin J. Gutierrez & Arun C. Habermann & Taylor S. Adams & Jonas C. Schupp & Sergio Poli & Lance M. Peter & Chase J. Taylor & Jessica, 2021. "Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    18. Jesus González-Rubio & Carmen Navarro-López & Elena López-Nájera & Ana López-Nájera & Lydia Jiménez-Díaz & Juan D. Navarro-López & Alberto Nájera, 2020. "A Systematic Review and Meta-Analysis of Hospitalised Current Smokers and COVID-19," IJERPH, MDPI, vol. 17(20), pages 1-16, October.
    19. Arthur Eumann Mesas & Iván Cavero-Redondo & Celia Álvarez-Bueno & Marcos Aparecido Sarriá Cabrera & Selma Maffei de Andrade & Irene Sequí-Dominguez & Vicente Martínez-Vizcaíno, 2020. "Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-23, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8552-:d:613786. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.