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Associations of Genetic Variations in ABCA1 and Lifestyle Factors with Coronary Artery Disease in a Southern Chinese Population with Dyslipidemia: A Nested Case-Control Study

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  • Tian-Yu Zhao

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China
    Medical School, Shihezi University, Shihezi 832000, China
    These authors contributed equally to this work.)

  • Song Lei

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China
    Medical School, Shihezi University, Shihezi 832000, China
    These authors contributed equally to this work.)

  • Liu Huang

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China)

  • Yi-Nan Wang

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China)

  • Xiao-Ni Wang

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China)

  • Ping-Pu Zhou

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China)

  • Xiao-Jun Xu

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China)

  • Long Zhang

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China)

  • Liang-Wen Xu

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China)

  • Lei Yang

    (Medical School, Hangzhou Normal University, Hangzhou 310000, China)

Abstract

Coronary artery disease has become a major health concern over the past several decades. We aimed to explore the association of single nucleotide polymorphisms (SNPs) in the ATP-binding cassette subfamily A member 1 ( ABCA1 ) and lifestyle factors with coronary artery disease (CAD) in dyslipidemia. This nested case-control study included 173 patients with CAD and 500 matched control individuals (1:3, case: control) from a district in southern China. We collected medical reports, lifestyle details, and blood samples of individuals with dyslipidemia and used the polymerase chain reaction-ligase detection reaction method to genotype the SNPs. The CC genotype of the additive and recessive models of rs4149339, together with regular intake of fried foods or dessert, increased the risk of CAD (adjusted odd ratio (OR) = 1.91, p = 0.030; adjusted OR = 1.97, p = 0.017; adjusted OR = 1.80, p = 0.002; adjusted OR = 1.98, p = 0.001). The AT + AA genotype of the dominant model of rs4743763 and moderate/heavy physical activity reduced the risk of CAD (adjusted OR = 0.66, p = 0.030; adjusted OR = 0.44, p = 0.001). The CT + CC genotype of the dominant model of rs2472386 reduced the risk of CAD only in males (adjusted OR = 0.36, p = 0.001). The interaction between rs4149339 and rs4743763 of ABCA1 and haplotype CTT (comprising rs4149339, rs4743763, and rs2472386) appeared to increase the risk of CAD (relative excess risk due to interaction (RERI) = 3.19, p = 0.045; OR = 1.49, p = 0.019). Polymorphisms of rs4149339, rs4743763 and rs2472386 in ABCA1 and three lifestyle factors (physical activity, fried food intake, and dessert intake) were associated with CAD in people with dyslipidemia in southern China. These results provide the theoretical basis for gene screening and the prevention of chronic cardiovascular diseases.

Suggested Citation

  • Tian-Yu Zhao & Song Lei & Liu Huang & Yi-Nan Wang & Xiao-Ni Wang & Ping-Pu Zhou & Xiao-Jun Xu & Long Zhang & Liang-Wen Xu & Lei Yang, 2019. "Associations of Genetic Variations in ABCA1 and Lifestyle Factors with Coronary Artery Disease in a Southern Chinese Population with Dyslipidemia: A Nested Case-Control Study," IJERPH, MDPI, vol. 16(5), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:5:p:786-:d:210822
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    1. Dariush Mozaffarian & Renata Micha & Sarah Wallace, 2010. "Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials," PLOS Medicine, Public Library of Science, vol. 7(3), pages 1-10, March.
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    1. Zheng Li & Cheng-Yin Ye & Li Wang & Jin-Mei Li & Lei Yang, 2020. "Association of Genetic and Environmental Factors with Non-Alcoholic Fatty Liver Disease in a Chinese Han Population," IJERPH, MDPI, vol. 17(14), pages 1-14, July.

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