IDEAS home Printed from https://ideas.repec.org/a/eee/tefoso/v155y2020ics0040162518315580.html
   My bibliography  Save this article

The role of policies and the contribution of cluster agency in the development of biotech open innovation ecosystem

Author

Listed:
  • Vlaisavljevic, Vesna
  • Medina, Carmen Cabello
  • Van Looy, Bart

Abstract

Building on the open innovation and cluster literature, our research describes how innovation policies contribute to the development of open innovation dynamics in biotech clusters. Particularly, we address the role and impact of cluster agency by adopting a contextualized perspective. We carry out comparative case studies of the main five Spanish biotech clusters by combining longitudinal data extracted from secondary sources with primary data obtained from relevant stakeholders. Our study shows that clusters policies do not yield uniform effects; the impact in terms of patterns of collaboration and (open) innovation dynamics is path dependent. The characteristics of the local texture significantly contribute to the observed open innovation ecosystems. As such, these findings imply a plea for contextualizing regional policy initiatives.

Suggested Citation

  • Vlaisavljevic, Vesna & Medina, Carmen Cabello & Van Looy, Bart, 2020. "The role of policies and the contribution of cluster agency in the development of biotech open innovation ecosystem," Technological Forecasting and Social Change, Elsevier, vol. 155(C).
  • Handle: RePEc:eee:tefoso:v:155:y:2020:i:c:s0040162518315580
    DOI: 10.1016/j.techfore.2020.119987
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0040162518315580
    Download Restriction: Full text for ScienceDirect subscribers only

    File URL: https://libkey.io/10.1016/j.techfore.2020.119987?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Romer, Paul M, 1986. "Increasing Returns and Long-run Growth," Journal of Political Economy, University of Chicago Press, vol. 94(5), pages 1002-1037, October.
    2. Georgeanne M. Artz & Younjun Kim & Peter F. Orazem, 2016. "Does Agglomeration Matter Everywhere?: New Firm Location Decisions In Rural And Urban Markets," Journal of Regional Science, Wiley Blackwell, vol. 56(1), pages 72-95, January.
    3. Etzkowitz, Henry & Leydesdorff, Loet, 2000. "The dynamics of innovation: from National Systems and "Mode 2" to a Triple Helix of university-industry-government relations," Research Policy, Elsevier, vol. 29(2), pages 109-123, February.
    4. Belussi, Fiorenza & Sammarra, Alessia & Sedita, Silvia Rita, 2010. "Learning at the boundaries in an "Open Regional Innovation System": A focus on firms' innovation strategies in the Emilia Romagna life science industry," Research Policy, Elsevier, vol. 39(6), pages 710-721, July.
    5. Brian Mccann & Timothy Folta, 2011. "Performance differentials within geographic clusters," Post-Print hal-02312592, HAL.
    6. Junbo Yu & Randall Jackson, 2011. "Regional Innovation Clusters: A Critical Review," Growth and Change, Wiley Blackwell, vol. 42(2), pages 111-124, June.
    7. Junichi Nishimura & Hiroyuki Okamuro, 2011. "R&D productivity and the organization of cluster policy: an empirical evaluation of the Industrial Cluster Project in Japan," The Journal of Technology Transfer, Springer, vol. 36(2), pages 117-144, April.
    8. Mads Bruun Ingstrup, 2010. "The role of cluster facilitators," International Journal of Globalisation and Small Business, Inderscience Enterprises Ltd, vol. 4(1), pages 25-40.
    9. Valentina Lazzarotti & Raffaella Manzini, 2009. "Different Modes Of Open Innovation: A Theoretical Framework And An Empirical Study," International Journal of Innovation Management (ijim), World Scientific Publishing Co. Pte. Ltd., vol. 13(04), pages 615-636.
    10. Youtie, Jan & Shapira, Philip, 2008. "Building an innovation hub: A case study of the transformation of university roles in regional technological and economic development," Research Policy, Elsevier, vol. 37(8), pages 1188-1204, September.
    11. Ingstrup, Mads Bruun, 2013. "Facilitating Different Types of Clusters," management revue. Socio-economic Studies, Rainer Hampp Verlag, vol. 24(2), pages 133-150.
    12. Cooke, Philip & Gomez Uranga, Mikel & Etxebarria, Goio, 1997. "Regional innovation systems: Institutional and organisational dimensions," Research Policy, Elsevier, vol. 26(4-5), pages 475-491, December.
    13. Claudia Werker, 2006. "An Assessment of the Regional Innovation Policy by the European Union based on Bibliometrical Analysis," Papers on Economics and Evolution 2006-11, Philipps University Marburg, Department of Geography.
    14. Susana Borrás & Jacint Jordana, 2016. "When regional innovation policies meet policy rationales and evidence: a plea for policy analysis," European Planning Studies, Taylor & Francis Journals, vol. 24(12), pages 2133-2153, December.
    15. McCann, Brian T. & Folta, Timothy B., 2011. "Performance differentials within geographic clusters," Journal of Business Venturing, Elsevier, vol. 26(1), pages 104-123, January.
    16. Delgado, Mercedes & Porter, Michael E. & Stern, Scott, 2014. "Clusters, convergence, and economic performance," Research Policy, Elsevier, vol. 43(10), pages 1785-1799.
    17. Loet Leydesdorff & Henry Etzkowitz, 1996. "Emergence of a Triple Helix of university—industry—government relations," Science and Public Policy, Oxford University Press, vol. 23(5), pages 279-286, October.
    18. Paavo Ritala & Vassilis Agouridas & Dimitris Assimakopoulos & Otto Gies, 2013. "Value creation and capture mechanisms in innovation ecosystems : a comparative case study," Post-Print hal-02313379, HAL.
    19. Marshall, Alfred, 1920. "Industry and Trade," History of Economic Thought Books, McMaster University Archive for the History of Economic Thought, edition 3, number marshall1920.
    20. Catherine Lecocq & Bart Leten & Jeroen Kusters & Bart van Looy, 2012. "Do Firms Benefit from being Present in Multiple Technology Clusters? An Assessment of the Technological Performance of Biopharmaceutical Firms," Regional Studies, Taylor & Francis Journals, vol. 46(9), pages 1107-1119, October.
    21. He, Zheng & Rayman-Bacchus, Lez & Wu, Yiming, 2011. "Self-organization of industrial clustering in a transition economy: A proposed framework and case study evidence from China," Research Policy, Elsevier, vol. 40(9), pages 1280-1294.
    22. Lucas Figal Garone & Alessandro Maffioli & Joao Negri & Cesar Rodriguez & Gonzalo Vázquez-Baré, 2015. "Cluster development policy, SME’s performance, and spillovers: evidence from Brazil," Small Business Economics, Springer, vol. 44(4), pages 925-948, April.
    23. Ingstrup, Mads Bruun, 2013. "Facilitating Different Types of Clusters," management revue - Socio-Economic Studies, Nomos Verlagsgesellschaft mbH & Co. KG, vol. 24(2), pages 133-150.
    24. Sara Cruz & Aurora Teixeira, 2010. "The Evolution of the Cluster Literature: Shedding Light on the Regional Studies-Regional Science Debate," Regional Studies, Taylor & Francis Journals, vol. 44(9), pages 1263-1288.
    25. K. J. Arrow, 1971. "The Economic Implications of Learning by Doing," Palgrave Macmillan Books, in: F. H. Hahn (ed.), Readings in the Theory of Growth, chapter 11, pages 131-149, Palgrave Macmillan.
    26. Ron Boschma & Dirk Fornahl, 2011. "Cluster Evolution and a Roadmap for Future Research," Regional Studies, Taylor & Francis Journals, vol. 45(10), pages 1295-1298, November.
    27. Asheim, Bjorn T. & Coenen, Lars, 2005. "Knowledge bases and regional innovation systems: Comparing Nordic clusters," Research Policy, Elsevier, vol. 34(8), pages 1173-1190, October.
    28. Michael Porter & Christian Ketels, 2009. "Clusters and Industrial Districts: Common Roots, Different Perspectives," Chapters, in: Giacomo Becattini & Marco Bellandi & Lisa De Propis (ed.), A Handbook of Industrial Districts, chapter 14, Edward Elgar Publishing.
    29. Catherine Lecocq & Bart Van Looy, 2016. "Editor's Choice What differentiates top regions in the field of biotechnology? An empirical study of the texture characteristics of biotech regions in North America, Europe, and Asia-Pacific," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 25(4), pages 671-688.
    30. Laura Ahonen & Tuija Hämäläinen, 2012. "CLIQ: A Practical Approach to the Quadruple Helix and More Open Innovation," Innovation, Technology, and Knowledge Management, in: Steven P. MacGregor & Tamara Carleton (ed.), Sustaining Innovation, edition 1, chapter 0, pages 15-29, Springer.
    31. Cooke, Philip, 2001. "Regional Innovation Systems, Clusters, and the Knowledge Economy," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 10(4), pages 945-974, December.
    32. Bjørn Asheim & Ron Boschma & Philip Cooke, 2011. "Constructing Regional Advantage: Platform Policies Based on Related Variety and Differentiated Knowledge Bases," Regional Studies, Taylor & Francis Journals, vol. 45(7), pages 893-904.
    33. Ron Adner & Rahul Kapoor, 2010. "Value creation in innovation ecosystems: how the structure of technological interdependence affects firm performance in new technology generations," Strategic Management Journal, Wiley Blackwell, vol. 31(3), pages 306-333, March.
    34. Maryann P. Feldman & Johanna L. Francis, 2003. "Fortune Favours the Prepared Region: The Case of Entrepreneurship and the Capitol Region Biotechnology Cluster," European Planning Studies, Taylor & Francis Journals, vol. 11(7), pages 765-788, October.
    35. Franz Tödtling & Peter Prud'homme van Reine & Steffen Dörhöfer, 2011. "Open Innovation and Regional Culture—Findings from Different Industrial and Regional Settings," European Planning Studies, Taylor & Francis Journals, vol. 19(11), pages 1885-1907, January.
    36. Maskell, Peter, 2001. "Towards a Knowledge-Based Theory of the Geographical Cluster," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 10(4), pages 921-943, December.
    37. Michaela Trippl & Markus Grillitsch & Arne Isaksen & Tanja Sinozic, 2015. "Perspectives on Cluster Evolution: Critical Review and Future Research Issues," European Planning Studies, Taylor & Francis Journals, vol. 23(10), pages 2028-2044, October.
    38. Ron Martin & Peter Sunley, 2003. "Deconstructing clusters: chaotic concept or policy panacea?," Journal of Economic Geography, Oxford University Press, vol. 3(1), pages 5-35, January.
    39. Toni Ahlqvist, 2014. "Building Innovation Excellence of World Class: The Cluster as an Instrument of Spatial Governance in the European Union," International Journal of Urban and Regional Research, Wiley Blackwell, vol. 38(5), pages 1712-1731, September.
    40. Christian Lechner & Christophe Leyronas, 2012. "The competitive advantage of cluster firms: the priority of regional network position over extra-regional networks -- a study of a French high-tech cluster," Entrepreneurship & Regional Development, Taylor & Francis Journals, vol. 24(5-6), pages 457-473, June.
    41. Michele Mastroeni & Joyce Tait & Alessandro Rosiello, 2013. "Regional innovation policies in a globally connected environment," Science and Public Policy, Oxford University Press, vol. 40(1), pages 8-16, January.
    42. Iris Wanzenböck & Thomas Scherngell & Thomas Brenner, 2014. "Embeddedness of regions in European knowledge networks: a comparative analysis of inter-regional R&D collaborations, co-patents and co-publications," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 337-368, September.
    43. Todtling, Franz & Trippl, Michaela, 2005. "One size fits all?: Towards a differentiated regional innovation policy approach," Research Policy, Elsevier, vol. 34(8), pages 1203-1219, October.
    44. Gilbert, Brett Anitra & McDougall, Patricia P. & Audretsch, David B., 2008. "Clusters, knowledge spillovers and new venture performance: An empirical examination," Journal of Business Venturing, Elsevier, vol. 23(4), pages 405-422, July.
    45. Hiroyuki Okamuro & Junichi Nishimura, 2015. "Local Management of National Cluster Policies: Comparative Case Studies of Japanese, German, and French Biotechnology Clusters," Administrative Sciences, MDPI, vol. 5(4), pages 1-27, November.
    46. Catherine Lecocq & Bart Looy, 2009. "The impact of collaboration on the technological performance of regions: time invariant or driven by life cycle dynamics?," Scientometrics, Springer;Akadémiai Kiadó, vol. 80(3), pages 845-865, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lepore, Dominique & Frontoni, Emanuele & Micozzi, Alessandra & Moccia, Sara & Romeo, Luca & Spigarelli, Francesca, 2023. "Uncovering the potential of innovation ecosystems in the healthcare sector after the COVID-19 crisis," Health Policy, Elsevier, vol. 127(C), pages 80-86.
    2. Alberto Bettanti & Antonella Lanati & Alessandro Missoni, 2022. "Biopharmaceutical innovation ecosystems: a stakeholder model and the case of Lombardy," The Journal of Technology Transfer, Springer, vol. 47(6), pages 1948-1973, December.
    3. Xiaoran Zheng & Yuzhuo Cai, 2022. "Transforming Innovation Systems into Innovation Ecosystems: The Role of Public Policy," Sustainability, MDPI, vol. 14(12), pages 1-26, June.
    4. Selma Leticia Capinzaiki Ottonicar & Paloma Marin Arraiza & Fabiano Armellini, 2020. "Opening Science and Innovation: Opportunities for Emerging Economies," Foresight and STI Governance (Foresight-Russia till No. 3/2015), National Research University Higher School of Economics, vol. 14(4), pages 95-111.
    5. Sh Moradi & S Abdi, 2023. "Open science–related policies in Europe," Science and Public Policy, Oxford University Press, vol. 50(3), pages 521-530.
    6. Baier-Fuentes, Hugo & Guerrero, Maribel & Amorós, José Ernesto, 2021. "Does triple helix collaboration matter for the early internationalisation of technology-based firms in emerging Economies?," Technological Forecasting and Social Change, Elsevier, vol. 163(C).
    7. Okpalaoka, Chijindu Iheanacho, 2023. "Research on the digital economy: Developing trends and future directions," Technological Forecasting and Social Change, Elsevier, vol. 193(C).
    8. Xie, Xuemei & Wang, Hongwei, 2021. "How to bridge the gap between innovation niches and exploratory and exploitative innovations in open innovation ecosystems," Journal of Business Research, Elsevier, vol. 124(C), pages 299-311.
    9. Joanna Helman, 2020. "Analysis of the Local Innovation and Entrepreneurial System Structure Towards the ‘Wrocław Innovation Ecosystem’ Concept Development," Sustainability, MDPI, vol. 12(23), pages 1-17, December.
    10. Yanzhang Gu & Longying Hu & Hongjin Zhang & Chenxuan Hou, 2021. "Innovation Ecosystem Research: Emerging Trends and Future Research," Sustainability, MDPI, vol. 13(20), pages 1-21, October.
    11. Liping Fu & Fan Wu & Shan Zhang, 2022. "Evolutionary Path and Innovative Development of Pharmaceutical Industrial Cluster—A Case Study of Shijiazhuang, China," IJERPH, MDPI, vol. 19(5), pages 1-18, March.
    12. Asplund, Fredrik & Björk, Jennie & Magnusson, Mats & Patrick, Adam J, 2021. "The genesis of public-private innovation ecosystems: Bias and challenges✰," Technological Forecasting and Social Change, Elsevier, vol. 162(C).
    13. Jun Yao & Huajing Li & Di Shang & Luyang Ding, 2021. "Evolution of the Industrial Innovation Ecosystem of Resource-Based Cities (RBCs): A Case Study of Shanxi Province, China," Sustainability, MDPI, vol. 13(20), pages 1-17, October.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. James Wilson & Emily Wise & Madeline Smith, 2022. "Evidencing the benefits of cluster policies: towards a generalised framework of effects," Policy Sciences, Springer;Society of Policy Sciences, vol. 55(2), pages 369-391, June.
    2. Hiroyuki Okamuro & Junichi Nishimura, 2020. "What Shapes Local Innovation Policies? Empirical Evidence from Japanese Cities," Administrative Sciences, MDPI, vol. 10(1), pages 1-22, February.
    3. Dirk Crass & Christian Rammer & Birgit Aschhoff, 2019. "Geographical clustering and the effectiveness of public innovation programs," The Journal of Technology Transfer, Springer, vol. 44(6), pages 1784-1815, December.
    4. Vitaly L. Tambovtsev, 2022. "Clusters: Coordination, inter-firm relationships and competitive advantages," Upravlenets, Ural State University of Economics, vol. 13(1), pages 20-36, March.
    5. Lindomar Subtil Oliveira & Márcia E. Soares Echeveste & Marcelo Nogueira Cortimiglia & Aline C. Gularte, 2019. "Open Innovation in Regional Innovation Systems: Assessment of Critical Success Factors for Implementation in SMEs," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 10(4), pages 1597-1619, December.
    6. Dahesh, Mehran Badin & Tabarsa, Gholamali & Zandieh, Mostafa & Hamidizadeh, Mohammadreza, 2020. "Reviewing the intellectual structure and evolution of the innovation systems approach: A social network analysis," Technology in Society, Elsevier, vol. 63(C).
    7. Ingstrup, Mads Bruun, 2013. "Facilitating Different Types of Clusters," management revue - Socio-Economic Studies, Nomos Verlagsgesellschaft mbH & Co. KG, vol. 24(2), pages 133-150.
    8. Erik E. Lehmann & Matthias Menter, 2018. "Public cluster policy and performance," The Journal of Technology Transfer, Springer, vol. 43(3), pages 558-592, June.
    9. Scaringella, Laurent & Radziwon, Agnieszka, 2018. "Innovation, entrepreneurial, knowledge, and business ecosystems: Old wine in new bottles?," Technological Forecasting and Social Change, Elsevier, vol. 136(C), pages 59-87.
    10. Radziwon, Agnieszka & Bogers, Marcel, 2019. "Open innovation in SMEs: Exploring inter-organizational relationships in an ecosystem," Technological Forecasting and Social Change, Elsevier, vol. 146(C), pages 573-587.
    11. Michaela Trippl & Markus Grillitsch & Arne Isaksen & Tanja Sinozic, 2015. "Perspectives on Cluster Evolution: Critical Review and Future Research Issues," European Planning Studies, Taylor & Francis Journals, vol. 23(10), pages 2028-2044, October.
    12. Reza Naghizadeh & Shaban Elahi & Manoochehr Manteghi & Sepehr Ghazinoory & Marina Ranga, 2015. "Through the magnifying glass: an analysis of regional innovation models based on co-word and meta-synthesis methods," Quality & Quantity: International Journal of Methodology, Springer, vol. 49(6), pages 2481-2505, November.
    13. Haifeng Qian, 2018. "Knowledge-Based Regional Economic Development: A Synthetic Review of Knowledge Spillovers, Entrepreneurship, and Entrepreneurial Ecosystems," Economic Development Quarterly, , vol. 32(2), pages 163-176, May.
    14. Hiroyuki Okamuro & Junichi Nishimura, 2021. "Effects of multilevel policy mix of public R&D subsidies: Empirical evidence from Japanese local SMEs [The Impact of R&D Subsidies on R&D Employment Composition]," Science and Public Policy, Oxford University Press, vol. 48(6), pages 829-840.
    15. Paola Rucker Schaeffer & Bruno Fischer & Sergio Queiroz, 2018. "Beyond Education: The Role of Research Universities in Innovation Ecosystems," Foresight and STI Governance (Foresight-Russia till No. 3/2015), National Research University Higher School of Economics, vol. 12(2), pages 50-61.
    16. Rakas, Marija & Hain, Daniel S., 2019. "The state of innovation system research: What happens beneath the surface?," Research Policy, Elsevier, vol. 48(9), pages 1-1.
    17. Moutinho, Ricardo & Au-Yong-Oliveira, Manuel & Coelho, Arnaldo & Manso, José Pires, 2015. "Beyond the “Innovation's Black-Box”: Translating R&D outlays into employment and economic growth," Socio-Economic Planning Sciences, Elsevier, vol. 50(C), pages 45-58.
    18. Grashof, Nils, 2020. "Putting the watering can away Towards a targeted (problem-oriented) cluster policy framework," Papers in Innovation Studies 2020/4, Lund University, CIRCLE - Centre for Innovation Research.
    19. Madeline Smith & James R. Wilson & Emily Wise, 2020. "Evaluating clusters: Where theory collides with practice," Regional Science Policy & Practice, Wiley Blackwell, vol. 12(3), pages 413-430, June.
    20. Trippl , Michaela & Grillitsch , Markus & Isaksen , Arne & Sinozic , Tanja, 2015. "Understanding Cluster Evolution," Papers in Innovation Studies 2015/46, Lund University, CIRCLE - Centre for Innovation Research.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:tefoso:v:155:y:2020:i:c:s0040162518315580. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.sciencedirect.com/science/journal/00401625 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.