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Hopf bifurcation analysis and optimal control of Treatment in a delayed oncolytic virus dynamics

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  • Kim, Kwang Su
  • Kim, Sangil
  • Jung, Il Hyo

Abstract

During cancer viral therapy, there is a time delay from the initial virus infection of the tumor cells up to the time those infected cells reach the stage of being able to infect other cells. Because the duration of this “time delay” varies with each virus, it is important to understand how the delay affects the cancer viral therapy. Herein, we have introduced a mathematical model to explain this time delay. The existence of equilibrium (i.e., whether the treatment was unsuccessful or partially successful) was determined in this model by using a basic reproduction ratio of viral infection (R0) to immune response (R1). By using the bifurcation parameter as a delay τ, we proved a sufficient condition for the local asymptotic stability of two equilibrium points and the existence of Hopf bifurcation. In addition, we observed that the time delay caused the partial success equilibrium to be unstable and worked together with Hopf bifurcation to create a stable periodic oscillation. Therefore, we investigated the effects of viral cytotoxicity or infection rate, which are characteristics of viruses, on the Hopf bifurcation point. In order to support the analytical findings and to further analyze the effects of delay during cancer viral therapy, we reconstructed the model to include two controls: cancer viral therapy and immunotherapy. In addition, using numerical simulation, we suggested an optimal control problem to examine the effects of delay on oncolytic immunotherapy.

Suggested Citation

  • Kim, Kwang Su & Kim, Sangil & Jung, Il Hyo, 2018. "Hopf bifurcation analysis and optimal control of Treatment in a delayed oncolytic virus dynamics," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 149(C), pages 1-16.
  • Handle: RePEc:eee:matcom:v:149:y:2018:i:c:p:1-16
    DOI: 10.1016/j.matcom.2018.01.003
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    References listed on IDEAS

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    1. Li, Xiuling & Wei, Junjie, 2005. "On the zeros of a fourth degree exponential polynomial with applications to a neural network model with delays," Chaos, Solitons & Fractals, Elsevier, vol. 26(2), pages 519-526.
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    Cited by:

    1. Elaiw, A.M. & Hobiny, A.D. & Al Agha, A.D., 2020. "Global dynamics of reaction-diffusion oncolytic M1 virotherapy with immune response," Applied Mathematics and Computation, Elsevier, vol. 367(C).
    2. Kumar, Pushpendra & Erturk, Vedat Suat & Yusuf, Abdullahi & Kumar, Sunil, 2021. "Fractional time-delay mathematical modeling of Oncolytic Virotherapy," Chaos, Solitons & Fractals, Elsevier, vol. 150(C).
    3. Huang, Chengdai & Liu, Heng & Chen, Xiaoping & Zhang, Minsong & Ding, Ling & Cao, Jinde & Alsaedi, Ahmed, 2020. "Dynamic optimal control of enhancing feedback treatment for a delayed fractional order predator–prey model," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 554(C).
    4. Li, Hui-zhong & Liu, Xiang-dong & Yan, Rui & Liu, Cheng, 2020. "Hopf bifurcation analysis of a tumor virotherapy model with two time delays," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 553(C).
    5. Amine, Saida & Hajri, Youssra & Allali, Karam, 2022. "A delayed fractional-order tumor virotherapy model: Stability and Hopf bifurcation," Chaos, Solitons & Fractals, Elsevier, vol. 161(C).

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