IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v161y2022ics0960077922006063.html
   My bibliography  Save this article

A delayed fractional-order tumor virotherapy model: Stability and Hopf bifurcation

Author

Listed:
  • Amine, Saida
  • Hajri, Youssra
  • Allali, Karam

Abstract

A fractional-order tumor virotherapy model with two time delays is presented and analyzed in this paper. The existence, positivity and bounbdedness of solutions under positive initial conditions will be proved. The basic reproduction number R0 and the immune response reproduction number R1 are given. The virus-free equilibrium E0 and the therapy partial success equilibrium E∗ are presented depending on the value of R0 and R1. Sufficient conditions to ensure the local stability of both the virus-free equilibrium and the therapy partial success equilibrium according to different values of two time delays are established. By considering the time delay as a bifurcation parameter, it was appeared that the model undergoes a Hopf bifurcation when the delay passes through a critical value. Finally, numerical simulations were carried out to support the theoretical results and to show the effect of both the fractional-order derivative and the time delays.

Suggested Citation

  • Amine, Saida & Hajri, Youssra & Allali, Karam, 2022. "A delayed fractional-order tumor virotherapy model: Stability and Hopf bifurcation," Chaos, Solitons & Fractals, Elsevier, vol. 161(C).
    • Handle: RePEc:eee:chsofr:v:161:y:2022:i:c:s0960077922006063
    DOI: 10.1016/j.chaos.2022.112396
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077922006063
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2022.112396?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Kim, Kwang Su & Kim, Sangil & Jung, Il Hyo, 2018. "Hopf bifurcation analysis and optimal control of Treatment in a delayed oncolytic virus dynamics," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 149(C), pages 1-16.
    2. Scalas, Enrico & Gorenflo, Rudolf & Mainardi, Francesco, 2000. "Fractional calculus and continuous-time finance," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 284(1), pages 376-384.
    3. Deshpande, Amey S. & Daftardar-Gejji, Varsha & Sukale, Yogita V., 2017. "On Hopf bifurcation in fractional dynamical systems," Chaos, Solitons & Fractals, Elsevier, vol. 98(C), pages 189-198.
    4. Xu, Changjin & Liao, Maoxin & Li, Peiluan & Yuan, Shuai, 2021. "Impact of leakage delay on bifurcation in fractional-order complex-valued neural networks," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).
    5. Li, Hui-zhong & Liu, Xiang-dong & Yan, Rui & Liu, Cheng, 2020. "Hopf bifurcation analysis of a tumor virotherapy model with two time delays," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 553(C).
    6. Kumar, Pushpendra & Erturk, Vedat Suat & Yusuf, Abdullahi & Kumar, Sunil, 2021. "Fractional time-delay mathematical modeling of Oncolytic Virotherapy," Chaos, Solitons & Fractals, Elsevier, vol. 150(C).
    7. Xu, Changjin & Liu, Zixin & Yao, Lingyun & Aouiti, Chaouki, 2021. "Further exploration on bifurcation of fractional-order six-neuron bi-directional associative memory neural networks with multi-delays," Applied Mathematics and Computation, Elsevier, vol. 410(C).
    8. Mainardi, Francesco & Raberto, Marco & Gorenflo, Rudolf & Scalas, Enrico, 2000. "Fractional calculus and continuous-time finance II: the waiting-time distribution," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 287(3), pages 468-481.
    9. Bourafa, S. & Abdelouahab, M-S. & Moussaoui, A., 2020. "On some extended Routh–Hurwitz conditions for fractional-order autonomous systems of order α ∈ (0, 2) and their applications to some population dynamic models," Chaos, Solitons & Fractals, Elsevier, vol. 133(C).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Marseguerra, Marzio & Zoia, Andrea, 2008. "Pre-asymptotic corrections to fractional diffusion equations," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 387(12), pages 2668-2674.
    2. Zheng, Guang-Hui & Zhang, Quan-Guo, 2018. "Solving the backward problem for space-fractional diffusion equation by a fractional Tikhonov regularization method," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 148(C), pages 37-47.
    3. Scalas, Enrico & Kaizoji, Taisei & Kirchler, Michael & Huber, Jürgen & Tedeschi, Alessandra, 2006. "Waiting times between orders and trades in double-auction markets," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 366(C), pages 463-471.
    4. Álvaro Cartea & Thilo Meyer-Brandis, 2010. "How Duration Between Trades of Underlying Securities Affects Option Prices," Review of Finance, European Finance Association, vol. 14(4), pages 749-785.
    5. Saberi Zafarghandi, Fahimeh & Mohammadi, Maryam & Babolian, Esmail & Javadi, Shahnam, 2019. "Radial basis functions method for solving the fractional diffusion equations," Applied Mathematics and Computation, Elsevier, vol. 342(C), pages 224-246.
    6. G. Fern'andez-Anaya & L. A. Quezada-T'ellez & B. Nu~nez-Zavala & D. Brun-Battistini, 2019. "Katugampola Generalized Conformal Derivative Approach to Inada Conditions and Solow-Swan Economic Growth Model," Papers 1907.00130, arXiv.org.
    7. Ya Qin & Adnan Khan & Izaz Ali & Maysaa Al Qurashi & Hassan Khan & Rasool Shah & Dumitru Baleanu, 2020. "An Efficient Analytical Approach for the Solution of Certain Fractional-Order Dynamical Systems," Energies, MDPI, vol. 13(11), pages 1-14, May.
    8. Scalas, Enrico & Gallegati, Mauro & Guerci, Eric & Mas, David & Tedeschi, Alessandra, 2006. "Growth and allocation of resources in economics: The agent-based approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 370(1), pages 86-90.
    9. Jorge E. Macías-Díaz, 2019. "Numerically Efficient Methods for Variational Fractional Wave Equations: An Explicit Four-Step Scheme," Mathematics, MDPI, vol. 7(11), pages 1-27, November.
    10. Boukhouima, Adnane & Hattaf, Khalid & Lotfi, El Mehdi & Mahrouf, Marouane & Torres, Delfim F.M. & Yousfi, Noura, 2020. "Lyapunov functions for fractional-order systems in biology: Methods and applications," Chaos, Solitons & Fractals, Elsevier, vol. 140(C).
    11. Hussam Aljarrah & Mohammad Alaroud & Anuar Ishak & Maslina Darus, 2022. "Approximate Solution of Nonlinear Time-Fractional PDEs by Laplace Residual Power Series Method," Mathematics, MDPI, vol. 10(12), pages 1-16, June.
    12. Hayashi, Katsuhiko & Kaizoji, Taisei & Pichl, Lukáš, 2007. "Correlation patterns of NIKKEI index constituents," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 383(1), pages 16-21.
    13. Jiang, Zhi-Qiang & Chen, Wei & Zhou, Wei-Xing, 2009. "Detrended fluctuation analysis of intertrade durations," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(4), pages 433-440.
    14. Enrico Scalas & Rudolf Gorenflo & Hugh Luckock & Francesco Mainardi & Maurizio Mantelli & Marco Raberto, 2004. "Anomalous waiting times in high-frequency financial data," Quantitative Finance, Taylor & Francis Journals, vol. 4(6), pages 695-702.
    15. Hosseininia, M. & Heydari, M.H., 2019. "Meshfree moving least squares method for nonlinear variable-order time fractional 2D telegraph equation involving Mittag–Leffler non-singular kernel," Chaos, Solitons & Fractals, Elsevier, vol. 127(C), pages 389-399.
    16. Gu, Hui & Liang, Jin-Rong & Zhang, Yun-Xiu, 2012. "Time-changed geometric fractional Brownian motion and option pricing with transaction costs," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 391(15), pages 3971-3977.
    17. Ali Balcı, Mehmet, 2017. "Time fractional capital-induced labor migration model," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 477(C), pages 91-98.
    18. Berardi, Luca & Serva, Maurizio, 2005. "Time and foreign exchange markets," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 353(C), pages 403-412.
    19. Masoliver, Jaume & Montero, Miquel & Perello, Josep & Weiss, George H., 2006. "The continuous time random walk formalism in financial markets," Journal of Economic Behavior & Organization, Elsevier, vol. 61(4), pages 577-598, December.
    20. Mainardi, Francesco & Raberto, Marco & Gorenflo, Rudolf & Scalas, Enrico, 2000. "Fractional calculus and continuous-time finance II: the waiting-time distribution," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 287(3), pages 468-481.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:161:y:2022:i:c:s0960077922006063. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.