IDEAS home Printed from https://ideas.repec.org/a/eee/jmvana/v143y2016icp107-126.html
   My bibliography  Save this article

Inference for high-dimensional differential correlation matrices

Author

Listed:
  • Cai, T. Tony
  • Zhang, Anru

Abstract

Motivated by differential co-expression analysis in genomics, we consider in this paper estimation and testing of high-dimensional differential correlation matrices. An adaptive thresholding procedure is introduced and theoretical guarantees are given. Minimax rate of convergence is established and the proposed estimator is shown to be adaptively rate-optimal over collections of paired correlation matrices with approximately sparse differences. Simulation results show that the procedure significantly outperforms two other natural methods that are based on separate estimation of the individual correlation matrices. The procedure is also illustrated through an analysis of a breast cancer dataset, which provides evidence at the gene co-expression level that several genes, of which a subset has been previously verified, are associated with the breast cancer. Hypothesis testing on the differential correlation matrices is also considered. A test, which is particularly well suited for testing against sparse alternatives, is introduced. In addition, other related problems, including estimation of a single sparse correlation matrix, estimation of the differential covariance matrices, and estimation of the differential cross-correlation matrices, are also discussed.

Suggested Citation

  • Cai, T. Tony & Zhang, Anru, 2016. "Inference for high-dimensional differential correlation matrices," Journal of Multivariate Analysis, Elsevier, vol. 143(C), pages 107-126.
    • Handle: RePEc:eee:jmvana:v:143:y:2016:i:c:p:107-126
    DOI: 10.1016/j.jmva.2015.08.019
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0047259X15002110
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.jmva.2015.08.019?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Cai, Tony & Liu, Weidong, 2011. "Adaptive Thresholding for Sparse Covariance Matrix Estimation," Journal of the American Statistical Association, American Statistical Association, vol. 106(494), pages 672-684.
    2. P. Shaw & D. Greenstein & J. Lerch & L. Clasen & R. Lenroot & N. Gogtay & A. Evans & J. Rapoport & J. Giedd, 2006. "Intellectual ability and cortical development in children and adolescents," Nature, Nature, vol. 440(7084), pages 676-679, March.
    3. Chen, Songxi, 2012. "Two Sample Tests for High Dimensional Covariance Matrices," MPRA Paper 46026, University Library of Munich, Germany.
    4. Schott, James R., 2007. "A test for the equality of covariance matrices when the dimension is large relative to the sample sizes," Computational Statistics & Data Analysis, Elsevier, vol. 51(12), pages 6535-6542, August.
    5. Rothman, Adam J. & Levina, Elizaveta & Zhu, Ji, 2009. "Generalized Thresholding of Large Covariance Matrices," Journal of the American Statistical Association, American Statistical Association, vol. 104(485), pages 177-186.
    6. Srivastava, Muni S. & Yanagihara, Hirokazu, 2010. "Testing the equality of several covariance matrices with fewer observations than the dimension," Journal of Multivariate Analysis, Elsevier, vol. 101(6), pages 1319-1329, July.
    7. Tony Cai & Weidong Liu & Yin Xia, 2013. "Two-Sample Covariance Matrix Testing and Support Recovery in High-Dimensional and Sparse Settings," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 108(501), pages 265-277, March.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chen, Xin & Yang, Dan & Xu, Yan & Xia, Yin & Wang, Dong & Shen, Haipeng, 2023. "Testing and support recovery of correlation structures for matrix-valued observations with an application to stock market data," Journal of Econometrics, Elsevier, vol. 232(2), pages 544-564.
    2. Long Feng & Tiefeng Jiang & Binghui Liu & Wei Xiong, 2020. "Max-sum tests for cross-sectional dependence of high-demensional panel data," Papers 2007.03911, arXiv.org.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chen, Song Xi & Guo, Bin & Qiu, Yumou, 2023. "Testing and signal identification for two-sample high-dimensional covariances via multi-level thresholding," Journal of Econometrics, Elsevier, vol. 235(2), pages 1337-1354.
    2. Chen, Xin & Yang, Dan & Xu, Yan & Xia, Yin & Wang, Dong & Shen, Haipeng, 2023. "Testing and support recovery of correlation structures for matrix-valued observations with an application to stock market data," Journal of Econometrics, Elsevier, vol. 232(2), pages 544-564.
    3. Tao Zhang & Zhiwen Wang & Yanling Wan, 2021. "Functional test for high-dimensional covariance matrix, with application to mitochondrial calcium concentration," Statistical Papers, Springer, vol. 62(3), pages 1213-1230, June.
    4. Li, Weiming & Qin, Yingli, 2014. "Hypothesis testing for high-dimensional covariance matrices," Journal of Multivariate Analysis, Elsevier, vol. 128(C), pages 108-119.
    5. Zhang, Yangchun & Zhou, Yirui & Liu, Xiaowei, 2023. "Applications on linear spectral statistics of high-dimensional sample covariance matrix with divergent spectrum," Computational Statistics & Data Analysis, Elsevier, vol. 178(C).
    6. Tsukuda, Koji & Matsuura, Shun, 2019. "High-dimensional testing for proportional covariance matrices," Journal of Multivariate Analysis, Elsevier, vol. 171(C), pages 412-420.
    7. Zhidong Bai & Jiang Hu & Chen Wang & Chao Zhang, 2021. "Test on the linear combinations of covariance matrices in high-dimensional data," Statistical Papers, Springer, vol. 62(2), pages 701-719, April.
    8. Muni S. Srivastava & Hirokazu Yanagihara & Tatsuya Kubokawa, 2014. "Tests for Covariance Matrices in High Dimension with Less Sample Size," CIRJE F-Series CIRJE-F-933, CIRJE, Faculty of Economics, University of Tokyo.
    9. Deepak Nag Ayyala & Santu Ghosh & Daniel F. Linder, 2022. "Covariance matrix testing in high dimension using random projections," Computational Statistics, Springer, vol. 37(3), pages 1111-1141, July.
    10. Jinyuan Chang & Wen Zhou & Wen-Xin Zhou & Lan Wang, 2017. "Comparing large covariance matrices under weak conditions on the dependence structure and its application to gene clustering," Biometrics, The International Biometric Society, vol. 73(1), pages 31-41, March.
    11. Xie, Jichun & Kang, Jian, 2017. "High-dimensional tests for functional networks of brain anatomic regions," Journal of Multivariate Analysis, Elsevier, vol. 156(C), pages 70-88.
    12. Ziqi Chen & Chenlei Leng, 2016. "Dynamic Covariance Models," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(515), pages 1196-1207, July.
    13. Yin Xia, 2017. "Testing and support recovery of multiple high-dimensional covariance matrices with false discovery rate control," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 26(4), pages 782-801, December.
    14. Yumou Qiu & Song Xi Chen, 2015. "Bandwidth Selection for High-Dimensional Covariance Matrix Estimation," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 110(511), pages 1160-1174, September.
    15. Tsukuda, Koji & Matsuura, Shun, 2021. "Limit theorem associated with Wishart matrices with application to hypothesis testing for common principal components," Journal of Multivariate Analysis, Elsevier, vol. 186(C).
    16. Thulin, Måns, 2014. "A high-dimensional two-sample test for the mean using random subspaces," Computational Statistics & Data Analysis, Elsevier, vol. 74(C), pages 26-38.
    17. Fan, Jianqing & Liao, Yuan & Shi, Xiaofeng, 2015. "Risks of large portfolios," Journal of Econometrics, Elsevier, vol. 186(2), pages 367-387.
    18. Seunghwan Lee & Sang Cheol Kim & Donghyeon Yu, 2023. "An efficient GPU-parallel coordinate descent algorithm for sparse precision matrix estimation via scaled lasso," Computational Statistics, Springer, vol. 38(1), pages 217-242, March.
    19. Peng, Liuhua & Chen, Song Xi & Zhou, Wen, 2016. "More powerful tests for sparse high-dimensional covariances matrices," Journal of Multivariate Analysis, Elsevier, vol. 149(C), pages 124-143.
    20. Jin-Chuan Duan & Weimin Miao, 2016. "Default Correlations and Large-Portfolio Credit Analysis," Journal of Business & Economic Statistics, Taylor & Francis Journals, vol. 34(4), pages 536-546, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:jmvana:v:143:y:2016:i:c:p:107-126. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/wps/find/journaldescription.cws_home/622892/description#description .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.