The effect of RCTs on drug demand: Evidence from off-label cancer drugs
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DOI: 10.1016/j.jhealeco.2023.102779
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- Janet M. Currie & W. Bentley MacLeod, 2020. "Understanding Doctor Decision Making: The Case of Depression Treatment," Econometrica, Econometric Society, vol. 88(3), pages 847-878, May.
- Pradeep Chintagunta & Renna Jiang & Ginger Jin, 2009.
"Information, learning, and drug diffusion: The case of Cox-2 inhibitors,"
Quantitative Marketing and Economics (QME), Springer, vol. 7(4), pages 399-443, December.
- Pradeep Chintadunta & Renna Jiang & Ginger Z. Jin, 2008. "Information, Learning, and Drug Diffusion: the Case of Cox-2 Inhibitors," NBER Working Papers 14252, National Bureau of Economic Research, Inc.
- Janet M. Currie & W. Bentley MacLeod, 2018.
"Understanding Doctor Decision Making: The Case of Depression,"
NBER Working Papers
24955, National Bureau of Economic Research, Inc.
- Janet M. Currie & W. Bentley MacLeod, 2020. "Understanding Doctor Decision Making: The Case of Depression," Working Papers 2020-77, Princeton University. Economics Department..
- Clément de Chaisemartin & Xavier D'Haultfœuille, 2020.
"Two-Way Fixed Effects Estimators with Heterogeneous Treatment Effects,"
American Economic Review, American Economic Association, vol. 110(9), pages 2964-2996, September.
- Cl'ement de Chaisemartin & Xavier D'Haultf{oe}uille, 2018. "Two-way fixed effects estimators with heterogeneous treatment effects," Papers 1803.08807, arXiv.org, revised Mar 2020.
- Clément de Chaisemartin & Xavier D'Haultfoeuille, 2019. "Two-way Fixed Effects Estimators with Heterogeneous Treatment Effects," NBER Working Papers 25904, National Bureau of Economic Research, Inc.
- A. Colin Cameron & Jonah B. Gelbach & Douglas L. Miller, 2008.
"Bootstrap-Based Improvements for Inference with Clustered Errors,"
The Review of Economics and Statistics, MIT Press, vol. 90(3), pages 414-427, August.
- Jonah B. Gelbach & Doug Miller & A. Colin Cameron, 2006. "Bootstrap-Based Improvements for Inference with Clustered Errors," Working Papers 128, University of California, Davis, Department of Economics.
- A. Colin Cameron & Jonah B. Gelbach & Douglas L. Miller, 2007. "Bootstrap-Based Improvements for Inference with Clustered Errors," NBER Technical Working Papers 0344, National Bureau of Economic Research, Inc.
- Ajay Kalra & Shibo Li & Wei Zhang, 2011. "Understanding Responses to Contradictory Information About Products," Marketing Science, INFORMS, vol. 30(6), pages 1098-1114, November.
- Alberto Abadie & Susan Athey & Guido W Imbens & Jeffrey M Wooldridge, 2023.
"When Should You Adjust Standard Errors for Clustering?,"
The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 138(1), pages 1-35.
- Alberto Abadie & Susan Athey & Guido Imbens & Jeffrey Wooldridge, 2017. "When Should You Adjust Standard Errors for Clustering?," Papers 1710.02926, arXiv.org, revised Sep 2022.
- Alberto Abadie & Susan Athey & Guido W. Imbens & Jeffrey Wooldridge, 2017. "When Should You Adjust Standard Errors for Clustering?," NBER Working Papers 24003, National Bureau of Economic Research, Inc.
- Abadie, Alberto & Athey, Susan & Imbens, Guido W. & Wooldridge, Jeffrey, 2017. "When Should You Adjust Standard Errors for Clustering?," Research Papers repec:ecl:stabus:3596, Stanford University, Graduate School of Business.
- Djogbenou, Antoine A. & MacKinnon, James G. & Nielsen, Morten Ørregaard, 2019.
"Asymptotic theory and wild bootstrap inference with clustered errors,"
Journal of Econometrics, Elsevier, vol. 212(2), pages 393-412.
- Antoine A. Djogbenou & James G. MacKinnon & Morten Ø. Nielsen, 2018. "Asymptotic Theory And Wild Bootstrap Inference With Clustered Errors," Working Paper 1399, Economics Department, Queen's University.
- Antoine A. Djogbenou & James G. MacKinnon & Morten Ørregaard Nielsen, 2019. "Asymptotic Theory and Wild Bootstrap Inference with Clustered Errors," CREATES Research Papers 2019-05, Department of Economics and Business Economics, Aarhus University.
- Andrew T. Ching & Robert Clark & Ignatius Horstmann & Hyunwoo Lim, 2016.
"The Effects of Publicity on Demand: The Case of Anti-Cholesterol Drugs,"
Marketing Science, INFORMS, vol. 35(1), pages 158-181, January.
- Andrew Ching & Robert Clark & Ignatius Horstmann & Hyunwoo Lim, 2015. "The Effects of Publicity on Demand: The Case of Anti-cholesterol Drugs," Working Papers 150007, Canadian Centre for Health Economics.
- Andrew T. Ching & Hyunwoo Lim, 2020. "A Structural Model of Correlated Learning and Late-Mover Advantages: The Case of Statins," Management Science, INFORMS, vol. 66(3), pages 1095-1123, March.
- Clément de Chaisemartin & Xavier D’Haultfœuille, 2023.
"Two-way fixed effects and differences-in-differences with heterogeneous treatment effects: a survey,"
The Econometrics Journal, Royal Economic Society, vol. 26(3), pages 1-30.
- Cl'ement de Chaisemartin & Xavier D'Haultf{oe}uille, 2021. "Two-Way Fixed Effects and Differences-in-Differences with Heterogeneous Treatment Effects: A Survey," Papers 2112.04565, arXiv.org, revised Jun 2022.
- Clément de Chaisemartin & Xavier D’haultfœuille, 2022. "Two-Way Fixed Effects and Differences-in-Differences with Heterogeneous Treatment Effects: A Survey," SciencePo Working papers Main hal-03873885, HAL.
- Clément de Chaisemartin & Xavier D’haultfœuille, 2022. "Two-Way Fixed Effects and Differences-in-Differences with Heterogeneous Treatment Effects: A Survey," Post-Print hal-03873885, HAL.
- Clément de Chaisemartin & Xavier D'Haultfoeuille, 2022. "Two-Way Fixed Effects and Differences-in-Differences with Heterogeneous Treatment Effects: A Survey," NBER Working Papers 29734, National Bureau of Economic Research, Inc.
- Clément de Chaisemartin & Xavier D'Haultfoeuille, 2022. "Two-Way Fixed Effects and Differences-in-Differences with Heterogeneous Treatment Effects: A Survey," NBER Working Papers 29691, National Bureau of Economic Research, Inc.
- Xavier d'Haultfoeuille, 2022. "Two-way fixed effects and difference in differences with heterogeneous treatment effects: A survey," French Stata Users' Group Meetings 2022 01, Stata Users Group.
- Doruk Cengiz & Arindrajit Dube & Attila Lindner & Ben Zipperer, 2019. "The Effect of Minimum Wages on Low-Wage Jobs," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 134(3), pages 1405-1454.
- Matthew Grennan & Robert J. Town, 2020.
"Regulating Innovation with Uncertain Quality: Information, Risk, and Access in Medical Devices,"
American Economic Review, American Economic Association, vol. 110(1), pages 120-161, January.
- Matthew Grennan & Robert Town, 2015. "Regulating Innovation with Uncertain Quality: Information, Risk, and Access in Medical Devices," NBER Working Papers 20981, National Bureau of Economic Research, Inc.
- David H. Howard & Guy David & Jason Hockenberry, 2017.
"Selective Hearing: Physician‐Ownership and Physicians’ Response to New Evidence,"
Journal of Economics & Management Strategy, Wiley Blackwell, vol. 26(1), pages 152-168, February.
- David H. Howard & Guy David & Jason Hockenberry, 2016. "Selective Hearing: Physician-Ownership and Physicians' Response to New Evidence," NBER Working Papers 22171, National Bureau of Economic Research, Inc.
- Dubois, Pierre & Tunçel, Tuba, 2021.
"Identifying the effects of scientific information and recommendations on physicians’ prescribing behavior,"
Journal of Health Economics, Elsevier, vol. 78(C).
- Dubois, Pierre & Tuncel, Tuba, 2020. "Identifying the Effects of Scientific Information and Recommendations on Physicians’ Prescribing Behavior," TSE Working Papers 20-1114, Toulouse School of Economics (TSE).
- Leila Agha & David Molitor, 2018.
"The Local Influence of Pioneer Investigators on Technology Adoption: Evidence from New Cancer Drugs,"
The Review of Economics and Statistics, MIT Press, vol. 100(1), pages 29-44, March.
- Leila Agha & David Molitor, 2015. "The Local Influence of Pioneer Investigators on Technology Adoption: Evidence from New Cancer Drugs," NBER Working Papers 20878, National Bureau of Economic Research, Inc.
- Kenneth J. Arrow & L. Kamran Bilir & Alan Sorensen, 2020.
"The Impact of Information Technology on the Diffusion of New Pharmaceuticals,"
American Economic Journal: Applied Economics, American Economic Association, vol. 12(3), pages 1-39, July.
- Kenneth J. Arrow & Kamran Bilir & Alan T. Sorensen, 2017. "The Impact of Information Technology on the Diffusion of New Pharmaceuticals," NBER Working Papers 23257, National Bureau of Economic Research, Inc.
- Benjamin Berger & Amitabh Chandra & Craig Garthwaite, 2021. "Regulatory Approval and Expanded Market Size," NBER Working Papers 28889, National Bureau of Economic Research, Inc.
- Sriram Venkataraman & Stefan Stremersch, 2007. "The Debate on Influencing Doctors' Decisions: Are Drug Characteristics the Missing Link?," Management Science, INFORMS, vol. 53(11), pages 1688-1701, November.
- Andrew Ching & Masakazu Ishihara, 2010. "The effects of detailing on prescribing decisions under quality uncertainty," Quantitative Marketing and Economics (QME), Springer, vol. 8(2), pages 123-165, June.
- Gregory S. Crawford & Matthew Shum, 2005. "Uncertainty and Learning in Pharmaceutical Demand," Econometrica, Econometric Society, vol. 73(4), pages 1137-1173, July.
- Michael J. Dickstein, 2018. "Efficient Provision of Experience Goods: Evidence from Antidepressant Choice," Working Papers 18-17, New York University, Leonard N. Stern School of Business, Department of Economics.
- Eliana Barrenho & Eric Gautier & Marisa Miraldo & Carol Propper & Christiern Rose, 2020.
"Innovation Diffusion and Physician Networks: Keyhole Surgery for Cancer in the English NHS,"
Discussion Papers Series
638, School of Economics, University of Queensland, Australia.
- Propper, Carol & Barrenho, Eliana & Gautier, Eric & Miraldo, Marisa & Rose, Christiern, 2020. "Innovation Diffusion and Physician Networks: Keyhole Surgery for Cancer in the English NHS," CEPR Discussion Papers 15515, C.E.P.R. Discussion Papers.
- Callaway, Brantly & Sant’Anna, Pedro H.C., 2021.
"Difference-in-Differences with multiple time periods,"
Journal of Econometrics, Elsevier, vol. 225(2), pages 200-230.
- Brantly Callaway & Pedro H. C. Sant'Anna, 2018. "Difference-in-Differences with Multiple Time Periods," Papers 1803.09015, arXiv.org, revised Dec 2020.
- Pierre Azoulay, 2002. "Do Pharmaceutical Sales Respond to Scientific Evidence?," Journal of Economics & Management Strategy, Wiley Blackwell, vol. 11(4), pages 551-594, December.
- Julie Berez & Guy David & David H. Howard & Mark D. Neuman, 2018. "Does Bad News Travel Faster? On the Determinants of Medical Technology Abandonment," Journal of Human Capital, University of Chicago Press, vol. 12(4), pages 569-603.
- Ching, Andrew T. & Hermosilla, Manuel & Liu, Qiang, 2019. "Structural Models of the Prescription Drug Market," Foundations and Trends(R) in Marketing, now publishers, vol. 13(1), pages 1-1–76, December.
- Coscelli, Andrea & Shum, Matthew, 2004. "An empirical model of learning and patient spillovers in new drug entry," Journal of Econometrics, Elsevier, vol. 122(2), pages 213-246, October.
- Patricia M. Danzon & Eric L. Keuffel, 2014. "Regulation of the Pharmaceutical-Biotechnology Industry," NBER Chapters, in: Economic Regulation and Its Reform: What Have We Learned?, pages 407-484, National Bureau of Economic Research, Inc.
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- Xueyi Duan & Yinhe Liang & Xiaobo Peng, 2024. "Free school meals and cognitive ability: Evidence from China's student nutrition improvement plan," Health Economics, John Wiley & Sons, Ltd., vol. 33(7), pages 1480-1502, July.
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More about this item
Keywords
Pharmaceuticals; Off-label prescribing; Cancer; Healthcare economics; Regulation;All these keywords.
JEL classification:
- I11 - Health, Education, and Welfare - - Health - - - Analysis of Health Care Markets
- I18 - Health, Education, and Welfare - - Health - - - Government Policy; Regulation; Public Health
- L51 - Industrial Organization - - Regulation and Industrial Policy - - - Economics of Regulation
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