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Using integrated modeling to support the global eradication of vaccine‐preventable diseases

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  • Radboud J. Duintjer Tebbens
  • Kimberly M. Thompson

Abstract

The long‐term management of global disease eradication initiatives involves numerous inherently dynamic processes, health and economic trade‐offs, significant uncertainty and variability, rare events with big consequences, complex and interrelated decisions, and a requirement for cooperation among a large number of stakeholders. Over the course of more than 16 years of collaborative modeling efforts to support the Global Polio Eradication Initiative, we developed increasingly complex integrated system dynamics models that combined numerous analytical approaches, including differential equation‐based modeling, risk and decision analysis, discrete‐event and individual‐based simulation, probabilistic uncertainty and sensitivity analysis, health economics and optimization. We discuss the central role of systems thinking and system dynamics in the overall effort and the value of integrating different modeling approaches to appropriately address the trade‐offs involved in some of the policy questions. We discuss practical challenges of integrating different analytical tools and we provide our perspective on the future of integrated modeling. Copyright © 2018 System Dynamics Society

Suggested Citation

  • Radboud J. Duintjer Tebbens & Kimberly M. Thompson, 2018. "Using integrated modeling to support the global eradication of vaccine‐preventable diseases," System Dynamics Review, System Dynamics Society, vol. 34(1-2), pages 78-120, January.
    • Handle: RePEc:bla:sysdyn:v:34:y:2018:i:1-2:p:78-120
    DOI: 10.1002/sdr.1589
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    References listed on IDEAS

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    1. Kimberly M. Thompson & Radboud J. Duintjer Tebbens & Mark A. Pallansch & Olen M. Kew & Roland W. Sutter & R. Bruce Aylward & Margaret Watkins & Howard Gary & James P. Alexander & Linda Venczel & Denis, 2006. "Development and Consideration of Global Policies for Managing the Future Risks of Poliovirus Outbreaks: Insights and Lessons Learned Through Modeling," Risk Analysis, John Wiley & Sons, vol. 26(6), pages 1571-1580, December.
    2. Radboud J. Duintjer Tebbens & Mark A. Pallansch & Olen M. Kew & Victor M. Cáceres & Hamid Jafari & Stephen L. Cochi & Roland W. Sutter & R. Bruce Aylward & Kimberly M. Thompson, 2006. "Risks of Paralytic Disease Due to Wild or Vaccine‐Derived Poliovirus After Eradication," Risk Analysis, John Wiley & Sons, vol. 26(6), pages 1471-1505, December.
    3. Radboud J. Duintjer Tebbens & Mark A. Pallansch & Konstantin M. Chumakov & Neal A. Halsey & Tapani Hovi & Philip D. Minor & John F. Modlin & Peter A. Patriarca & Roland W. Sutter & Peter F. Wright & S, 2013. "Review and Assessment of Poliovirus Immunity and Transmission: Synthesis of Knowledge Gaps and Identification of Research Needs," Risk Analysis, John Wiley & Sons, vol. 33(4), pages 606-646, April.
    4. Radboud J. Duintjer Tebbens & Mark A. Pallansch & Dominika A. Kalkowska & Steven G. F. Wassilak & Stephen L. Cochi & Kimberly M. Thompson, 2013. "Characterizing Poliovirus Transmission and Evolution: Insights from Modeling Experiences with Wild and Vaccine‐Related Polioviruses," Risk Analysis, John Wiley & Sons, vol. 33(4), pages 703-749, April.
    5. Geoffard, Pierre-Yves & Philipson, Tomas, 1997. "Disease Eradication: Private versus Public Vaccination," American Economic Review, American Economic Association, vol. 87(1), pages 222-230, March.
    6. Kimberly M. Thompson & Radboud J. Duintjer Tebbens, 2016. "Framework for Optimal Global Vaccine Stockpile Design for Vaccine‐Preventable Diseases: Application to Measles and Cholera Vaccines as Contrasting Examples," Risk Analysis, John Wiley & Sons, vol. 36(7), pages 1487-1509, July.
    7. Hazhir Rahmandad & John Sterman, 2008. "Heterogeneity and Network Structure in the Dynamics of Diffusion: Comparing Agent-Based and Differential Equation Models," Management Science, INFORMS, vol. 54(5), pages 998-1014, May.
    8. Radboud J. Duintjer Tebbens & Mark A. Pallansch & Konstantin M. Chumakov & Neal A. Halsey & Tapani Hovi & Philip D. Minor & John F. Modlin & Peter A. Patriarca & Roland W. Sutter & Peter F. Wright & S, 2013. "Expert Review on Poliovirus Immunity and Transmission," Risk Analysis, John Wiley & Sons, vol. 33(4), pages 544-605, April.
    9. Thompson, K.M. & Duintjer Tebbens, R.J. & Pallansch, M.A. & Kew, O.M. & Sutter, R.W. & Aylward, R.B. & Watkins, M. & Gary Jr., H.E. & Alexander, J. & Jafari, H. & Cochi, S.L., 2008. "The risks, costs, and benefits of possible future global policies for managing polioviruses," American Journal of Public Health, American Public Health Association, vol. 98(7), pages 1322-1330.
    10. Radboud J. Duintjer Tebbens & Mark A. Pallansch & Jong‐Hoon Kim & Cara C. Burns & Olen M. Kew & M. Steven Oberste & Ousmane M. Diop & Steven G.F. Wassilak & Stephen L. Cochi & Kimberly M. Thompson, 2013. "Oral Poliovirus Vaccine Evolution and Insights Relevant to Modeling the Risks of Circulating Vaccine‐Derived Polioviruses (cVDPVs)," Risk Analysis, John Wiley & Sons, vol. 33(4), pages 680-702, April.
    11. Radboud J. Duintjer Tebbens & Kimberly M. Thompson, 2009. "Priority Shifting and the Dynamics of Managing Eradicable Infectious Diseases," Management Science, INFORMS, vol. 55(4), pages 650-663, April.
    12. Kimberly M. Thompson & Radboud J. Duintjer Tebbens & Mark A. Pallansch, 2006. "Evaluation of Response Scenarios to Potential Polio Outbreaks Using Mathematical Models," Risk Analysis, John Wiley & Sons, vol. 26(6), pages 1541-1556, December.
    13. Radboud J. Duintjer Tebbens & Mark A. Pallansch & Olen M. Kew & Roland W. Sutter & R. Bruce Aylward & Margaret Watkins & Howard Gary & James Alexander & Hamid Jafari & Stephen L. Cochi & Kimberly M. T, 2008. "Uncertainty and Sensitivity Analyses of a Decision Analytic Model for Posteradication Polio Risk Management," Risk Analysis, John Wiley & Sons, vol. 28(4), pages 855-876, August.
    14. Eva Lee & Siddhartha Maheshwary & Jacquelyn Mason & William Glisson, 2006. "Decision support system for mass dispensing of medications for infectious disease outbreaks and bioterrorist attacks," Annals of Operations Research, Springer, vol. 148(1), pages 25-53, November.
    15. Radboud J. Duintjer Tebbens & Nalinee Sangrujee & Kimberly M. Thompson, 2006. "The Costs of Future Polio Risk Management Policies," Risk Analysis, John Wiley & Sons, vol. 26(6), pages 1507-1531, December.
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    Cited by:

    1. Negar Darabi & Niyousha Hosseinichimeh, 2020. "System dynamics modeling in health and medicine: a systematic literature review," System Dynamics Review, System Dynamics Society, vol. 36(1), pages 29-73, January.
    2. Navid Ghaffarzadegan & Hazhir Rahmandad, 2020. "Simulation‐based estimation of the early spread of COVID‐19 in Iran: actual versus confirmed cases," System Dynamics Review, System Dynamics Society, vol. 36(1), pages 101-129, January.

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