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Impact of unknown covariance structures in semiparametric models for longitudinal data: An application to Wisconsin diabetes data

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  • Li, Jialiang
  • Xia, Yingcun
  • Palta, Mari
  • Shankar, Anoop

Abstract

Semiparametric models are becoming increasingly attractive for longitudinal data analysis. Often there is lack of knowledge of the covariance structure of the response variable. Although it is still possible to obtain consistent estimators for both parametric and nonparametric components of a semipatrametric model by assuming an identity structure for the covariance matrix, the resulting estimators may not be efficient. We conducted extensive simulation studies to investigate the impact of an unknown covariance structure on estimators in semiparametric models for longitudinal data. In some situations the loss of efficiency could be substantial. A two-step estimator is thus proposed to improve the efficiency. Our study was motivated by a population based data analysis to examine the temporal relationship between systolic blood pressure and urinary albumin excretion.

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  • Li, Jialiang & Xia, Yingcun & Palta, Mari & Shankar, Anoop, 2009. "Impact of unknown covariance structures in semiparametric models for longitudinal data: An application to Wisconsin diabetes data," Computational Statistics & Data Analysis, Elsevier, vol. 53(12), pages 4186-4197, October.
    • Handle: RePEc:eee:csdana:v:53:y:2009:i:12:p:4186-4197
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    References listed on IDEAS

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    Cited by:

    1. Chen, Ziqi & Shi, Ning-Zhong & Gao, Wei & Tang, Man-Lai, 2011. "Efficient semiparametric estimation via Cholesky decomposition for longitudinal data," Computational Statistics & Data Analysis, Elsevier, vol. 55(12), pages 3344-3354, December.
    2. Tao Huang & Jialiang Li, 2018. "Semiparametric model average prediction in panel data analysis," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 30(1), pages 125-144, January.
    3. Tuglus Catherine & van der Laan Mark J., 2011. "Repeated Measures Semiparametric Regression Using Targeted Maximum Likelihood Methodology with Application to Transcription Factor Activity Discovery," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 10(1), pages 1-31, January.

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