IDEAS home Printed from https://ideas.repec.org/a/bla/biomet/v74y2018i2p725-733.html
   My bibliography  Save this article

Cox regression model with doubly truncated data

Author

Listed:
  • Lior Rennert
  • Sharon X. Xie

Abstract

Truncation is a well†known phenomenon that may be present in observational studies of time†to†event data. While many methods exist to adjust for either left or right truncation, there are very few methods that adjust for simultaneous left and right truncation, also known as double truncation. We propose a Cox regression model to adjust for this double truncation using a weighted estimating equation approach, where the weights are estimated from the data both parametrically and nonparametrically, and are inversely proportional to the probability that a subject is observed. The resulting weighted estimators of the hazard ratio are consistent. The parametric weighted estimator is asymptotically normal and a consistent estimator of the asymptotic variance is provided. For the nonparametric weighted estimator, we apply the bootstrap technique to estimate the variance and confidence intervals. We demonstrate through extensive simulations that the proposed estimators greatly reduce the bias compared to the unweighted Cox regression estimator which ignores truncation. We illustrate our approach in an analysis of autopsy†confirmed Alzheimer's disease patients to assess the effect of education on survival.

Suggested Citation

  • Lior Rennert & Sharon X. Xie, 2018. "Cox regression model with doubly truncated data," Biometrics, The International Biometric Society, vol. 74(2), pages 725-733, June.
    • Handle: RePEc:bla:biomet:v:74:y:2018:i:2:p:725-733
    DOI: 10.1111/biom.12809
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/biom.12809
    Download Restriction: no
    File URL: https://libkey.io/10.1111/biom.12809?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Carla Moreira & Jacobo Uña-Álvarez & Ingrid Keilegom, 2014. "Goodness-of-fit tests for a semiparametric model under random double truncation," Computational Statistics, Springer, vol. 29(5), pages 1365-1379, October.
    2. Moreira, C. & de Uña-Álvarez, J. & Meira-Machado, L., 2016. "Nonparametric regression with doubly truncated data," Computational Statistics & Data Analysis, Elsevier, vol. 93(C), pages 294-307.
    3. Pao-sheng Shen, 2013. "Regression analysis of interval censored and doubly truncated data with linear transformation models," Computational Statistics, Springer, vol. 28(2), pages 581-596, April.
    4. Martin, Emily C. & Betensky, Rebecca A., 2005. "Testing Quasi-Independence of Failure and Truncation Times via Conditional Kendall's Tau," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 484-492, June.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Joshua R. Goldstein & Maria Osborne & Serge Atherwood & Casey F. Breen, 2023. "Mortality Modeling of Partially Observed Cohorts Using Administrative Death Records," Population Research and Policy Review, Springer;Southern Demographic Association (SDA), vol. 42(3), pages 1-20, June.
    2. Shen, Pao-sheng & Hsu, Huichen, 2020. "Conditional maximum likelihood estimation for semiparametric transformation models with doubly truncated data," Computational Statistics & Data Analysis, Elsevier, vol. 144(C).
    3. Bella Vakulenko‐Lagun & Micha Mandel & Rebecca A. Betensky, 2020. "Inverse probability weighting methods for Cox regression with right‐truncated data," Biometrics, The International Biometric Society, vol. 76(2), pages 484-495, June.
    4. Peng Liu & Kwun Chuen Gary Chan & Ying Qing Chen, 2023. "On a simple estimation of the proportional odds model under right truncation," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(3), pages 537-554, July.
    5. Casey Breen & Joshua R. Goldstein, 2022. "Berkeley Unified Numident Mortality Database: Public administrative records for individual-level mortality research," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 47(5), pages 111-142.
    6. Breen, Casey & Goldstein, Joshua R., 2022. "Berkeley Unified Numident Mortality Database: Public Administrative Records for Individual-Level Mortality Research," SocArXiv pc294, Center for Open Science.
    7. Lior Rennert & Sharon X. Xie, 2022. "Cox regression model under dependent truncation," Biometrics, The International Biometric Society, vol. 78(2), pages 460-473, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Shen, Pao-sheng & Hsu, Huichen, 2020. "Conditional maximum likelihood estimation for semiparametric transformation models with doubly truncated data," Computational Statistics & Data Analysis, Elsevier, vol. 144(C).
    2. Pao-sheng Shen & Yi Liu, 2019. "Pseudo maximum likelihood estimation for the Cox model with doubly truncated data," Statistical Papers, Springer, vol. 60(4), pages 1207-1224, August.
    3. Micha Mandel & Jacobo de Uña†à lvarez & David K. Simon & Rebecca A. Betensky, 2018. "Inverse probability weighted Cox regression for doubly truncated data," Biometrics, The International Biometric Society, vol. 74(2), pages 481-487, June.
    4. Yu Shen & Jing Ning & Jing Qin, 2017. "Nonparametric and semiparametric regression estimation for length-biased survival data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(1), pages 3-24, January.
    5. Takeshi Emura & Chi-Hung Pan, 2020. "Parametric likelihood inference and goodness-of-fit for dependently left-truncated data, a copula-based approach," Statistical Papers, Springer, vol. 61(1), pages 479-501, February.
    6. Stephan M. Bischofberger, 2020. "In-Sample Hazard Forecasting Based on Survival Models with Operational Time," Risks, MDPI, vol. 8(1), pages 1-17, January.
    7. Mackenzie Todd, 2012. "Survival Curve Estimation with Dependent Left Truncated Data Using Cox's Model," The International Journal of Biostatistics, De Gruyter, vol. 8(1), pages 1-20, October.
    8. Jing Qian & Sy Han Chiou & Rebecca A. Betensky, 2022. "Transformation model based regression with dependently truncated and independently censored data," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 71(2), pages 395-416, March.
    9. Takeshi Emura & Ya-Hsuan Hu & Yoshihiko Konno, 2017. "Asymptotic inference for maximum likelihood estimators under the special exponential family with double-truncation," Statistical Papers, Springer, vol. 58(3), pages 877-909, September.
    10. Emura, Takeshi & Konno, Yoshihiko, 2012. "A goodness-of-fit test for parametric models based on dependently truncated data," Computational Statistics & Data Analysis, Elsevier, vol. 56(7), pages 2237-2250.
    11. Lior Rennert & Sharon X. Xie, 2022. "Cox regression model under dependent truncation," Biometrics, The International Biometric Society, vol. 78(2), pages 460-473, June.
    12. Moreira, C. & de Uña-Álvarez, J. & Meira-Machado, L., 2016. "Nonparametric regression with doubly truncated data," Computational Statistics & Data Analysis, Elsevier, vol. 93(C), pages 294-307.
    13. Ying Wu & Richard J. Cook, 2018. "Variable selection and prediction in biased samples with censored outcomes," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(1), pages 72-93, January.
    14. Austin, Matthew D. & Betensky, Rebecca A., 2014. "Eliminating bias due to censoring in Kendall’s tau estimators for quasi-independence of truncation and failure," Computational Statistics & Data Analysis, Elsevier, vol. 73(C), pages 16-26.
    15. T. Emura & K. Murotani, 2015. "An algorithm for estimating survival under a copula-based dependent truncation model," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 24(4), pages 734-751, December.
    16. Carla Moreira & Jacobo de Uña-Álvarez & Roel Braekers, 2021. "Nonparametric estimation of a distribution function from doubly truncated data under dependence," Computational Statistics, Springer, vol. 36(3), pages 1693-1720, September.
    17. Chiou, Sy Han & Qian, Jing & Mormino, Elizabeth & Betensky, Rebecca A., 2018. "Permutation tests for general dependent truncation," Computational Statistics & Data Analysis, Elsevier, vol. 128(C), pages 308-324.
    18. van den Berg, Gerard J. & Effraimidis, Georgios, 2014. "Dependence Measures in Bivariate Gamma Frailty Models," IZA Discussion Papers 8083, Institute of Labor Economics (IZA).
    19. Achim Dörre & Chung-Yan Huang & Yi-Kuan Tseng & Takeshi Emura, 2021. "Likelihood-based analysis of doubly-truncated data under the location-scale and AFT model," Computational Statistics, Springer, vol. 36(1), pages 375-408, March.
    20. Rebecca A. Betensky & Jing Qian & Jingyao Hou, 2023. "Nonparametric and semiparametric estimation with sequentially truncated survival data," Biometrics, The International Biometric Society, vol. 79(2), pages 1000-1013, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bla:biomet:v:74:y:2018:i:2:p:725-733. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: http://www.blackwellpublishing.com/journal.asp?ref=0006-341X .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.