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Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach

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  • Anastasia Ivanova
  • Se Hee Kim

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  • Anastasia Ivanova & Se Hee Kim, 2009. "Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach," Biometrics, The International Biometric Society, vol. 65(1), pages 307-315, March.
    • Handle: RePEc:bla:biomet:v:65:y:2009:i:1:p:307-315
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    File URL: http://hdl.handle.net/10.1111/j.1541-0420.2008.01045.x
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    References listed on IDEAS

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    1. Z. Yuan & R. Chappell & H. Bailey, 2007. "The Continual Reassessment Method for Multiple Toxicity Grades: A Bayesian Quasi-Likelihood Approach," Biometrics, The International Biometric Society, vol. 63(1), pages 173-179, March.
    2. B. Nebiyou Bekele & Yu Shen, 2005. "A Bayesian Approach to Jointly Modeling Toxicity and Biomarker Expression in a Phase I/II Dose-Finding Trial," Biometrics, The International Biometric Society, vol. 61(2), pages 343-354, June.
    3. Bekele, B. Nebiyou & Thall, Peter F., 2004. "Dose-Finding Based on Multiple Toxicities in a Soft Tissue Sarcoma Trial," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 26-35, January.
    4. Anastasia Ivanova & Bahjat F. Qaqish & Michael J. Schell, 2005. "Continuous Toxicity Monitoring in Phase II Trials in Oncology," Biometrics, The International Biometric Society, vol. 61(2), pages 540-545, June.
    5. Ying Kuen Cheung & Rick Chappell, 2000. "Sequential Designs for Phase I Clinical Trials with Late-Onset Toxicities," Biometrics, The International Biometric Society, vol. 56(4), pages 1177-1182, December.
    6. Ying Kuen Cheung & Rick Chappell, 2002. "A Simple Technique to Evaluate Model Sensitivity in the Continual Reassessment Method," Biometrics, The International Biometric Society, vol. 58(3), pages 671-674, September.
    7. Ying Kuen Cheung, 2005. "Coherence principles in dose-finding studies," Biometrika, Biometrika Trust, vol. 92(4), pages 863-873, December.
    8. Anastasia Ivanova, 2003. "A New Dose-Finding Design for Bivariate Outcomes," Biometrics, The International Biometric Society, vol. 59(4), pages 1001-1007, December.
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    Cited by:

    1. Monia Ezzalfani, 2019. "How to design a dose-finding study on combined agents: Choice of design and development of R functions," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-24, November.
    2. B. Nebiyou Bekele & Yisheng Li & Yuan Ji, 2010. "Risk-Group-Specific Dose Finding Based on an Average Toxicity Score," Biometrics, The International Biometric Society, vol. 66(2), pages 541-548, June.

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