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Adaptive Estimation of Personalized Maximum Tolerated Dose in Cancer Phase I Clinical Trials Based on All Toxicities and Individual Genomic Profile

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  • Zhengjia Chen
  • Zheng Li
  • Run Zhuang
  • Ying Yuan
  • Michael Kutner
  • Taofeek Owonikoko
  • Walter J Curran
  • Jeanne Kowalski

Abstract

Background: Many biomarkers have been shown to be associated with the efficacy of cancer therapy. Estimation of personalized maximum tolerated doses (pMTDs) is a critical step toward personalized medicine, which aims to maximize the therapeutic effect of a treatment for individual patients. In this study, we have established a Bayesian adaptive Phase I design which can estimate pMTDs by utilizing patient biomarkers that can predict susceptibility to specific adverse events and response as covariates. Methods: Based on a cutting-edge cancer Phase I clinical trial design called escalation with overdose control using normalized equivalent toxicity score (EWOC-NETS), which fully utilizes all toxicities, we propose new models to incorporate patient biomarker information in the estimation of pMTDs for novel cancer therapeutic agents. The methodology is fully elaborated and the design operating characteristics are evaluated with extensive simulations. Results: Simulation studies demonstrate that the utilization of biomarkers in EWOC-NETS can estimate pMTDs while maintaining the original merits of this Phase I trial design, such as ethical constraint of overdose control and full utilization of all toxicity information, to improve the accuracy and efficiency of the pMTD estimation. Conclusions: Our novel cancer Phase I designs with inclusion of covariate(s) in the EWOC-NETS model are useful to estimate a personalized MTD and have substantial potential to improve the therapeutic effect of drug treatment.

Suggested Citation

  • Zhengjia Chen & Zheng Li & Run Zhuang & Ying Yuan & Michael Kutner & Taofeek Owonikoko & Walter J Curran & Jeanne Kowalski, 2017. "Adaptive Estimation of Personalized Maximum Tolerated Dose in Cancer Phase I Clinical Trials Based on All Toxicities and Individual Genomic Profile," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-18, January.
    • Handle: RePEc:plo:pone00:0170187
    DOI: 10.1371/journal.pone.0170187
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    References listed on IDEAS

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