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Sequential Designs for Phase I Clinical Trials with Late-Onset Toxicities

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  • Ying Kuen Cheung
  • Rick Chappell

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  • Ying Kuen Cheung & Rick Chappell, 2000. "Sequential Designs for Phase I Clinical Trials with Late-Onset Toxicities," Biometrics, The International Biometric Society, vol. 56(4), pages 1177-1182, December.
    • Handle: RePEc:bla:biomet:v:56:y:2000:i:4:p:1177-1182
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    File URL: http://hdl.handle.net/10.1111/j.0006-341X.2000.01177.x
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    Citations

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    Cited by:

    1. Thomas M. Braun, 2018. "Motivating sample sizes in adaptive Phase I trials via Bayesian posterior credible intervals," Biometrics, The International Biometric Society, vol. 74(3), pages 1065-1071, September.
    2. Alessandra Giovagnoli, 2021. "The Bayesian Design of Adaptive Clinical Trials," IJERPH, MDPI, vol. 18(2), pages 1-15, January.
    3. Graham M. Wheeler, 2018. "Incoherent dose-escalation in phase I trials using the escalation with overdose control approach," Statistical Papers, Springer, vol. 59(2), pages 801-811, June.
    4. Gerlinger, Christoph & Siedentop, Harald & Gerke, Oke & Schellschmidt, Ilka & Endrikat, Jan, 2012. "Optimal dose de-escalation trial designs for novel contraceptives in women," Computational Statistics & Data Analysis, Elsevier, vol. 56(5), pages 1061-1068.
    5. Ying Kuen Cheung & Peter F. Thall, 2002. "Monitoring the Rates of Composite Events with Censored Data in Phase II Clinical Trials," Biometrics, The International Biometric Society, vol. 58(1), pages 89-97, March.
    6. Yifei Zhang & Sha Cao & Chi Zhang & Ick Hoon Jin & Yong Zang, 2021. "A Bayesian adaptive phase I/II clinical trial design with late‐onset competing risk outcomes," Biometrics, The International Biometric Society, vol. 77(3), pages 796-808, September.
    7. Changying A. Liu & Thomas M. Braun, 2009. "Parametric non‐mixture cure models for schedule finding of therapeutic agents," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 58(2), pages 225-236, May.
    8. Nadine Houede & Peter F. Thall & Hoang Nguyen & Xavier Paoletti & Andrew Kramar, 2010. "Utility-Based Optimization of Combination Therapy Using Ordinal Toxicity and Efficacy in Phase I/II Trials," Biometrics, The International Biometric Society, vol. 66(2), pages 532-540, June.
    9. Anastasia Ivanova & Se Hee Kim, 2009. "Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach," Biometrics, The International Biometric Society, vol. 65(1), pages 307-315, March.
    10. Ying Kuen Cheung, 2002. "On the Use of Nonparametric Curves in Phase I Trials with Low Toxicity Tolerance," Biometrics, The International Biometric Society, vol. 58(1), pages 237-240, March.
    11. Ying Kuen Cheung & Rick Chappell, 2002. "A Simple Technique to Evaluate Model Sensitivity in the Continual Reassessment Method," Biometrics, The International Biometric Society, vol. 58(3), pages 671-674, September.
    12. Nigel Stallard & Peter F. Thall, 2001. "Decision-Theoretic Designs for Pre-Phase II Screening Trials in Oncology," Biometrics, The International Biometric Society, vol. 57(4), pages 1089-1095, December.
    13. Ying Yuan & Guosheng Yin, 2009. "Bayesian dose finding by jointly modelling toxicity and efficacy as time‐to‐event outcomes," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 58(5), pages 719-736, December.
    14. Tianjian Zhou & Wentian Guo & Yuan Ji, 2020. "PoD-TPI: Probability-of-Decision Toxicity Probability Interval Design to Accelerate Phase I Trials," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 12(2), pages 124-145, July.
    15. Peter F. Thall & Hoang Q. Nguyen & Thomas M. Braun & Muzaffar H. Qazilbash, 2013. "Using Joint Utilities of the Times to Response and Toxicity to Adaptively Optimize Schedule–Dose Regimes," Biometrics, The International Biometric Society, vol. 69(3), pages 673-682, September.
    16. Erica Brittain & Dean Follmann & Song Yang, 2008. "Dynamic Comparison of Kaplan–Meier Proportions: Monitoring a Randomized Clinical Trial with a Long-Term Binary Endpoint," Biometrics, The International Biometric Society, vol. 64(1), pages 189-197, March.
    17. Alexander M. Kaizer & Brian P. Hobbs & Joseph S. Koopmeiners, 2018. "A multi‐source adaptive platform design for testing sequential combinatorial therapeutic strategies," Biometrics, The International Biometric Society, vol. 74(3), pages 1082-1094, September.
    18. Yuan Ji & B. Nebiyou Bekele, 2009. "Adaptive Randomization for Multiarm Comparative Clinical Trials Based on Joint Efficacy/Toxicity Outcomes," Biometrics, The International Biometric Society, vol. 65(3), pages 876-884, September.
    19. Thomas M. Braun & Zheng Yuan & Peter F. Thall, 2005. "Determining a Maximum-Tolerated Schedule of a Cytotoxic Agent," Biometrics, The International Biometric Society, vol. 61(2), pages 335-343, June.
    20. B. Nebiyou Bekele & Yisheng Li & Yuan Ji, 2010. "Risk-Group-Specific Dose Finding Based on an Average Toxicity Score," Biometrics, The International Biometric Society, vol. 66(2), pages 541-548, June.

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