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A Simple Technique to Evaluate Model Sensitivity in the Continual Reassessment Method

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  • Ying Kuen Cheung
  • Rick Chappell

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  • Ying Kuen Cheung & Rick Chappell, 2002. "A Simple Technique to Evaluate Model Sensitivity in the Continual Reassessment Method," Biometrics, The International Biometric Society, vol. 58(3), pages 671-674, September.
    • Handle: RePEc:bla:biomet:v:58:y:2002:i:3:p:671-674
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    File URL: http://hdl.handle.net/10.1111/j.0006-341X.2002.00671.x
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    References listed on IDEAS

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    1. Mauro Gasparini & Jeffrey Eisele, 2000. "A Curve-Free Method for Phase I Clinical Trials," Biometrics, The International Biometric Society, vol. 56(2), pages 609-615, June.
    2. Ying Kuen Cheung & Rick Chappell, 2000. "Sequential Designs for Phase I Clinical Trials with Late-Onset Toxicities," Biometrics, The International Biometric Society, vol. 56(4), pages 1177-1182, December.
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    Cited by:

    1. Thomas M. Braun, 2018. "Motivating sample sizes in adaptive Phase I trials via Bayesian posterior credible intervals," Biometrics, The International Biometric Society, vol. 74(3), pages 1065-1071, September.
    2. Anastasia Ivanova & Se Hee Kim, 2009. "Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach," Biometrics, The International Biometric Society, vol. 65(1), pages 307-315, March.
    3. M. Clertant & J. O’Quigley, 2017. "Semiparametric dose finding methods," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 79(5), pages 1487-1508, November.
    4. Oron Assaf P. & Azriel David & Hoff Peter D., 2011. "Dose-Finding Designs: The Role of Convergence Properties," The International Journal of Biostatistics, De Gruyter, vol. 7(1), pages 1-17, October.
    5. Tianjian Zhou & Wentian Guo & Yuan Ji, 2020. "PoD-TPI: Probability-of-Decision Toxicity Probability Interval Design to Accelerate Phase I Trials," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 12(2), pages 124-145, July.
    6. Sweeting, Michael & Mander, Adrian & Sabin, Tony, 2013. "bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 54(i13).
    7. Azriel, David, 2014. "Optimal sequential designs in phase I studies," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 288-297.
    8. Azriel, David, 2012. "A note on the robustness of the continual reassessment method," Statistics & Probability Letters, Elsevier, vol. 82(5), pages 902-906.

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