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A Bayesian Approach to Jointly Modeling Toxicity and Biomarker Expression in a Phase I/II Dose-Finding Trial

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  • B. Nebiyou Bekele
  • Yu Shen

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  • B. Nebiyou Bekele & Yu Shen, 2005. "A Bayesian Approach to Jointly Modeling Toxicity and Biomarker Expression in a Phase I/II Dose-Finding Trial," Biometrics, The International Biometric Society, vol. 61(2), pages 343-354, June.
    • Handle: RePEc:bla:biomet:v:61:y:2005:i:2:p:343-354
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    File URL: http://hdl.handle.net/10.1111/j.1541-0420.2005.00314.x
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    References listed on IDEAS

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    1. Peter F. Thall & John D. Cook, 2004. "Dose-Finding Based on Efficacy–Toxicity Trade-Offs," Biometrics, The International Biometric Society, vol. 60(3), pages 684-693, September.
    2. Peter F. Thall & Hsi-Guang Sung & Aniruddha Choudhury, 2001. "Dose-Finding Based on Feasibility and Toxicity in T-cell Infusion Trials," Biometrics, The International Biometric Society, vol. 57(3), pages 914-921, September.
    3. James H. Albert & Siddhartha Chib, 2001. "Sequential Ordinal Modeling with Applications to Survival Data," Biometrics, The International Biometric Society, vol. 57(3), pages 829-836, September.
    4. Peter F. Thall & Randall E. Millikan & Peter Mueller & Sang-Joon Lee, 2003. "Dose-Finding with Two Agents in Phase I Oncology Trials," Biometrics, The International Biometric Society, vol. 59(3), pages 487-496, September.
    5. John O'Quigley & Michael D. Hughes & Terry Fenton, 2001. "Dose-Finding Designs for HIV Studies," Biometrics, The International Biometric Society, vol. 57(4), pages 1018-1029, December.
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    Cited by:

    1. Yinghui Zhou & John Whitehead & Pasi Korhonen & Mika Mustonen, 2008. "Implementation of a Bayesian Design in a Dose-Escalation Study of an Experimental Agent in Healthy Volunteers," Biometrics, The International Biometric Society, vol. 64(1), pages 299-308, March.
    2. Jiajing Xu & Guosheng Yin & David Ohlssen & Frank Bretz, 2016. "Bayesian two-stage dose finding for cytostatic agents via model adaptation," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 65(3), pages 465-482, April.
    3. Haitao Pan & Ping Huang & Zuoren Wang & Ling Wang & Chanjuan Li & Jielai Xia, 2013. "A Novel Bayesian Seamless Phase I/II Design," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-6, September.
    4. Anastasia Ivanova & Se Hee Kim, 2009. "Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach," Biometrics, The International Biometric Society, vol. 65(1), pages 307-315, March.
    5. Peter F. Thall & Hoang Q. Nguyen & Ralph G. Zinner, 2017. "Parametric dose standardization for optimizing two-agent combinations in a phase I–II trial with ordinal outcomes," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 66(1), pages 201-224, January.
    6. Peter F. Thall & Aniko Szabo & Hoang Q. Nguyen & Catherine M. Amlie-Lefond & Osama O. Zaidat, 2011. "Optimizing the Concentration and Bolus of a Drug Delivered by Continuous Infusion," Biometrics, The International Biometric Society, vol. 67(4), pages 1638-1646, December.
    7. Guosheng Yin & Yisheng Li & Yuan Ji, 2006. "Bayesian Dose-Finding in Phase I/II Clinical Trials Using Toxicity and Efficacy Odds Ratios," Biometrics, The International Biometric Society, vol. 62(3), pages 777-787, September.
    8. Mukhopadhyay, S. & Khuri, A.I., 2008. "Optimization in a multivariate generalized linear model situation," Computational Statistics & Data Analysis, Elsevier, vol. 52(10), pages 4625-4634, June.

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