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A class of hazard rate mixtures for combining survival data from different experiments

Author

Listed:
  • Antonio Lijoi

    (Department of Economics and Management, University of Pavia and Collegio Carlo Alberto)

  • Bernardo Nipoti

    (University of Turin and Collegio Carlo Alberto)

Abstract

Mixture models for hazard rate functions are widely used tools for addressing the statistical analysis of survival data subject to a censoring mechanism. The present paper introduces a new class of vectors of random hazard rate functions that are expressed as kernel mixtures of dependent completely random measures. This leads to define dependent nonparametric prior processes that are suitably tailored to draw inferences in the presence of heterogeneous observations. Besides its exibility, an important appealing feature of our proposal is analytical tractability: we are, indeed, able to determine some relevant distributional properties and a posterior characterization that is also the key for devising an efficient MCMC sampler. For illustrative purposes, we specialize our general results to a class of dependent extended gamma processes. We finally display a few numerical examples, including both simulated and real two-sample datasets: these allow us to identify the effect of a borrowing strength phenomenon and provide evidence of the effectiveness of the prior to deal with datasets for which the proportional hazards assumption does not hold true.

Suggested Citation

  • Antonio Lijoi & Bernardo Nipoti, 2013. "A class of hazard rate mixtures for combining survival data from different experiments," DEM Working Papers Series 059, University of Pavia, Department of Economics and Management.
    • Handle: RePEc:pav:demwpp:demwp0059
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    References listed on IDEAS

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    1. De Iorio, Maria & Muller, Peter & Rosner, Gary L. & MacEachern, Steven N., 2004. "An ANOVA Model for Dependent Random Measures," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 205-215, January.
    2. Pierpaolo De Blasi & Giovanni Peccati & Igor Prünster, 2009. "Asymptotics for posterior hazards," Carlo Alberto Notebooks 122, Collegio Carlo Alberto.
    3. Ishwaran, Hemant & James, Lancelot F., 2004. "Computational Methods for Multiplicative Intensity Models Using Weighted Gamma Processes: Proportional Hazards, Marked Point Processes, and Panel Count Data," Journal of the American Statistical Association, American Statistical Association, vol. 99, pages 175-190, January.
    4. Griffiths, R. C. & Milne, R. K., 1978. "A class of bivariate Poisson processes," Journal of Multivariate Analysis, Elsevier, vol. 8(3), pages 380-395, September.
    5. Rodríguez, Abel & Dunson, David B & Gelfand, Alan E, 2008. "The Nested Dirichlet Process," Journal of the American Statistical Association, American Statistical Association, vol. 103(483), pages 1131-1154.
    6. Griffin, J.E. & Steel, M.F.J., 2006. "Order-Based Dependent Dirichlet Processes," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 179-194, March.
    7. D. Zeng & D. Y. Lin, 2007. "Maximum likelihood estimation in semiparametric regression models with censored data," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 69(4), pages 507-564, September.
    8. Sangbum Choi & Xuelin Huang, 2012. "A General Class of Semiparametric Transformation Frailty Models for Nonproportional Hazards Survival Data," Biometrics, The International Biometric Society, vol. 68(4), pages 1126-1135, December.
    9. Teh, Yee Whye & Jordan, Michael I. & Beal, Matthew J. & Blei, David M., 2006. "Hierarchical Dirichlet Processes," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 1566-1581, December.
    10. Maria De Iorio & Wesley O. Johnson & Peter Müller & Gary L. Rosner, 2009. "Bayesian Nonparametric Nonproportional Hazards Survival Modeling," Biometrics, The International Biometric Society, vol. 65(3), pages 762-771, September.
    11. A. Jara & T. E. Hanson, 2011. "A class of mixtures of dependent tail-free processes," Biometrika, Biometrika Trust, vol. 98(3), pages 553-566.
    12. Lorenzo Trippa & Peter Müller & Wesley Johnson, 2011. "The multivariate beta process and an extension of the Polya tree model," Biometrika, Biometrika Trust, vol. 98(1), pages 17-34.
    13. J. E. Griffin & M. Kolossiatis & M. F. J. Steel, 2013. "Comparing distributions by using dependent normalized random-measure mixtures," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 75(3), pages 499-529, June.
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    Keywords

    Bayesian nonparametrics; Completely random measures; Dependent processes; Extended gamma processes; Partial exchangeability.;
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