IDEAS home Printed from https://ideas.repec.org/p/hal/journl/halshs-00981574.html
   My bibliography  Save this paper

Determinants of cross-regional R&D collaboration: some empirical evidence from Europe in biotechnology

Author

Listed:
  • Corinne Autant-Bernard

    (GATE Lyon Saint-Étienne - Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne - ENS de Lyon - École normale supérieure de Lyon - UL2 - Université Lumière - Lyon 2 - UCBL - Université Claude Bernard Lyon 1 - Université de Lyon - UJM - Université Jean Monnet - Saint-Étienne - CNRS - Centre National de la Recherche Scientifique)

  • Cilem Selin Hazir

    (GATE Lyon Saint-Étienne - Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne - ENS de Lyon - École normale supérieure de Lyon - UL2 - Université Lumière - Lyon 2 - UCBL - Université Claude Bernard Lyon 1 - Université de Lyon - UJM - Université Jean Monnet - Saint-Étienne - CNRS - Centre National de la Recherche Scientifique)

Abstract

In this study, we focus on the pattern of cross-regional R&D collaborations through which voluntary knowledge flows and accompanying spillovers might occur. Our aim is to investigate the processes that give rise to the observed network configuration in order to identify hampering factors of knowledge diffusion, with a particular interest in the role of geographical proximity and differences in territorial features. We make use of the data on project proposals submitted to the 7th Framework Programme in the field of biotechnology. We build a non-valued inter-regional R&D cooperation network among a set of European regions and study its formation through exponential random graph models (Frank and Strauss in J Am Stat Assoc 81(395):832–842, 1986 ; Wasserman and Pattison in Psychometrika 61(3):401–425, 1996 ). Besides the role played by absorptive capacities, the empirical results reveal that contiguity affects the pattern of cross-regional collaborations not only via edge formation among neighbours but also through a triadic closure process which links neighbouring regions to non-neighbours. Furthermore, triadic closure is found out to be in play among highly populated regions and regions including capital cities. Copyright Springer-Verlag Berlin Heidelberg 2014
(This abstract was borrowed from another version of this item.)

Suggested Citation

  • Corinne Autant-Bernard & Cilem Selin Hazir, 2014. "Determinants of cross-regional R&D collaboration: some empirical evidence from Europe in biotechnology," Post-Print halshs-00981574, HAL.
    • Handle: RePEc:hal:journl:halshs-00981574
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a search for a similarly titled item that would be available.

    Other versions of this item:

    References listed on IDEAS

    as
    1. Robert P. Gilles & Cathleen Johnson, 2000. "original papers : Spatial social networks," Review of Economic Design, Springer;Society for Economic Design, vol. 5(3), pages 273-299.
    2. Çilem Selin Hazir, 2013. "Multilateral R&D Collaboration: An ERGM Application on Biotechnology," Advances in Spatial Science, in: Thomas Scherngell (ed.), The Geography of Networks and R&D Collaborations, edition 127, chapter 0, pages 221-237, Springer.
    3. Adam B. Jaffe & Manuel Trajtenberg & Rebecca Henderson, 1993. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 108(3), pages 577-598.
    4. Jackson, Matthew O. & Wolinsky, Asher, 1996. "A Strategic Model of Social and Economic Networks," Journal of Economic Theory, Elsevier, vol. 71(1), pages 44-74, October.
    5. Cooke, Philip & Gomez Uranga, Mikel & Etxebarria, Goio, 1997. "Regional innovation systems: Institutional and organisational dimensions," Research Policy, Elsevier, vol. 26(4-5), pages 475-491, December.
    6. Jarno Hoekman & Koen Frenken & Frank Oort, 2009. "The geography of collaborative knowledge production in Europe," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 43(3), pages 721-738, September.
    7. Nicolas Carayol & Pascale Roux, 2007. "The Strategic Formation of Interindividual Collaboration Networks. Evidence from Co-invention Patterns," Annals of Economics and Statistics, GENES, issue 87-88, pages 275-301.
    8. Thomas Scherngell & Rafael Lata, 2013. "Towards an integrated European Research Area? Findings from Eigenvector spatially filtered spatial interaction models using European Framework Programme data," Papers in Regional Science, Wiley Blackwell, vol. 92(3), pages 555-577, August.
    9. Hagedoorn, John, 2002. "Inter-firm R&D partnerships: an overview of major trends and patterns since 1960," Research Policy, Elsevier, vol. 31(4), pages 477-492, May.
    10. Hoekman, Jarno & Frenken, Koen & Tijssen, Robert J.W., 2010. "Research collaboration at a distance: Changing spatial patterns of scientific collaboration within Europe," Research Policy, Elsevier, vol. 39(5), pages 662-673, June.
    11. Beaudry, Catherine & Schiffauerova, Andrea, 2011. "Impacts of collaboration and network indicators on patent quality: The case of Canadian nanotechnology innovation," European Management Journal, Elsevier, vol. 29(5), pages 362-376.
    12. M. S. Gertler & Y. M. Levitte, 2005. "Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation," Industry and Innovation, Taylor & Francis Journals, vol. 12(4), pages 487-507.
    13. C. Autant-Bernard & V. Mangematin & N. Massard, 2006. "Creation of Biotech SMEs in France," Small Business Economics, Springer, vol. 26(2), pages 173-187, March.
    14. C. Autant-Bernard & V. Mangematin & N. Massard, 2006. "Creation of Biotech SMEs in France," Small Business Economics, Springer, vol. 26(2), pages 173-187, March.
    15. repec:bla:econom:v:67:y:2000:i:267:p:307-24 is not listed on IDEAS
    16. Andersson, Martin & Karlsson, Charlie, 2005. "Knowledge Accessibility and Regional Economic Growth," Working Paper Series in Economics and Institutions of Innovation 40, Royal Institute of Technology, CESIS - Centre of Excellence for Science and Innovation Studies.
    17. Paul Almeida & Bruce Kogut, 1999. "Localization of Knowledge and the Mobility of Engineers in Regional Networks," Management Science, INFORMS, vol. 45(7), pages 905-917, July.
    18. Luc Anselin & Attila Varga & Zoltan Acs, 2008. "Geographical Spillovers and University Research: A Spatial Econometric Perspective," Chapters, in: Entrepreneurship, Growth and Public Policy, chapter 10, pages 122-134, Edward Elgar Publishing.
    19. repec:adr:anecst:y:2007:i:87-88:p:13 is not listed on IDEAS
    20. Ron Boschma, 2005. "Proximity and Innovation: A Critical Assessment," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 61-74.
    21. Jason Owen-Smith & Walter W. Powell, 2004. "Knowledge Networks as Channels and Conduits: The Effects of Spillovers in the Boston Biotechnology Community," Organization Science, INFORMS, vol. 15(1), pages 5-21, February.
    22. Lundvall, Bengt-Ake & Johnson, Bjorn & Andersen, Esben Sloth & Dalum, Bent, 2002. "National systems of production, innovation and competence building," Research Policy, Elsevier, vol. 31(2), pages 213-231, February.
    23. Stanley Wasserman & Philippa Pattison, 1996. "Logit models and logistic regressions for social networks: I. An introduction to Markov graphs andp," Psychometrika, Springer;The Psychometric Society, vol. 61(3), pages 401-425, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lorenzo CASSI & Emilie-Pauline GALLIÉ & Agénor LAHATTE & Valérie MERINDOL, 2018. "Scientific network centrality of European regions: the role of territorial resources," Region et Developpement, Region et Developpement, LEAD, Universite du Sud - Toulon Var, vol. 47, pages 5-26.
    2. Hermans, Frans, 2021. "The contribution of statistical network models to the study of clusters and their evolution," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 100(2), pages 379-403.
    3. Lili Wang & Xianwen Wang & Niels J. Philipsen, 2017. "Network structure of scientific collaborations between China and the EU member states," Scientometrics, Springer;Akadémiai Kiadó, vol. 113(2), pages 765-781, November.
    4. Lili Yuan & Yanni Hao & Minglu Li & Chunbing Bao & Jianping Li & Dengsheng Wu, 2018. "Who are the international research collaboration partners for China? A novel data perspective based on NSFC grants," Scientometrics, Springer;Akadémiai Kiadó, vol. 116(1), pages 401-422, July.
    5. Luigi Aldieri & Gennaro Guida & Maxim Kotsemir & Concetto Paolo Vinci, 2019. "An investigation of impact of research collaboration on academic performance in Italy," Quality & Quantity: International Journal of Methodology, Springer, vol. 53(4), pages 2003-2040, July.
    6. Mitze, Timo & Strotebeck, Falk, 2019. "Determining factors of interregional research collaboration in Germany's biotech network: Capacity, proximity, policy?," Technovation, Elsevier, vol. 80, pages 40-53.
    7. Gergő Tóth & Sándor Juhász & Zoltán Elekes & Balázs Lengyel, 2021. "Repeated collaboration of inventors across European regions," European Planning Studies, Taylor & Francis Journals, vol. 29(12), pages 2252-2272, December.
    8. Mitze, Timo & Strotebeck, Falk, 2017. "Modeling interregional research collaborations in German biotechnology using industry directory data: A quantitative social network analysis," MPRA Paper 83392, University Library of Munich, Germany.
    9. Cilem Selin Hazir & James Lesage & Corinne Autant-Bernard, 2014. "The Role of R&D Collaboration Networks on Regional Innovation Performance," Working Papers halshs-01073031, HAL.
    10. Luqi Li & Ben Derudder & Wei Shen & Xiang Kong, 2022. "Exploring the dynamics of the disaggregated intercity corporate network in the Yangtze River Delta, China: a relational event approach," Journal of Geographical Systems, Springer, vol. 24(1), pages 115-140, January.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Cilem Selin Hazir & Corinne Autant-Bernard, 2012. "Using Affiliation Networks to Study the Determinants of Multilateral Research Cooperation Some empirical evidence from EU Framework Programs in biotechnology," Working Papers 1212, Groupe d'Analyse et de Théorie Economique Lyon St-Étienne (GATE Lyon St-Étienne), Université de Lyon.
    2. Corinne Autant-Bernard & Cilem Selin Hazir, 2011. "Conceptualizing the Role of Geographical Proximity in Project Based R&D Networks: A Literature Survey," Post-Print halshs-00674345, HAL.
    3. Cilem Selin Hazir & James Lesage & Corinne Autant-Bernard, 2014. "The Role of R&D Collaboration Networks on Regional Innovation Performance," Working Papers halshs-01073031, HAL.
    4. Ernest Miguélez & Rosina Moreno, 2013. "Do Labour Mobility and Technological Collaborations Foster Geographical Knowledge Diffusion? The Case of European Regions," Growth and Change, Wiley Blackwell, vol. 44(2), pages 321-354, June.
    5. Kaihuang Zhang & Qinglan Qian & Yijing Zhao, 2020. "Evolution of Guangzhou Biomedical Industry Innovation Network Structure and Its Proximity Mechanism," Sustainability, MDPI, vol. 12(6), pages 1-20, March.
    6. Der-Shiuan Lee & Breandán Ó Huallacháin, 2012. "Spatial Network-based and Regional Proximity in US Biotechnology," Chapters, in: Marina van Geenhuizen & Peter Nijkamp (ed.), Creative Knowledge Cities, chapter 12, Edward Elgar Publishing.
    7. Tom Broekel & Pierre-Alexandre Balland & Martijn Burger & Frank Oort, 2014. "Modeling knowledge networks in economic geography: a discussion of four methods," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 423-452, September.
    8. Tom Broekel & Pierre-Alexandre Balland & Martijn Burger & Frank van Oort, 2013. "Modeling Knowledge Networks in Economic Geography: A Discussion of Four Empirical Strategies," Papers in Evolutionary Economic Geography (PEEG) 1325, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Dec 2013.
    9. Rosina Moreno & Ernest Miguélez, 2012. "A Relational Approach To The Geography Of Innovation: A Typology Of Regions," Journal of Economic Surveys, Wiley Blackwell, vol. 26(3), pages 492-516, July.
    10. Morescalchi, Andrea & Pammolli, Fabio & Penner, Orion & Petersen, Alexander M. & Riccaboni, Massimo, 2015. "The evolution of networks of innovators within and across borders: Evidence from patent data," Research Policy, Elsevier, vol. 44(3), pages 651-668.
    11. Koen Frenken & Roderik Ponds & Frank Van Oort, 2010. "The citation impact of research collaboration in science‐based industries: A spatial‐institutional analysis," Papers in Regional Science, Wiley Blackwell, vol. 89(2), pages 351-271, June.
    12. Gergő Tóth & Sándor Juhász & Zoltán Elekes & Balázs Lengyel, 2021. "Repeated collaboration of inventors across European regions," European Planning Studies, Taylor & Francis Journals, vol. 29(12), pages 2252-2272, December.
    13. Ron Boschma & Pierre-Alexandre Balland & Mathijs de Vaan, 2014. "The formation of economic networks: a proximity approach," Chapters, in: André Torre & Frédéric Wallet (ed.), Regional Development and Proximity Relations, chapter 7, pages 243-266, Edward Elgar Publishing.
    14. Yutao Sun & Kai Liu, 2016. "Proximity effect, preferential attachment and path dependence in inter-regional network: a case of China’s technology transaction," Scientometrics, Springer;Akadémiai Kiadó, vol. 108(1), pages 201-220, July.
    15. Takashi Iino & Hiroyasu Inoue & Yukiko U. Saito & Yasuyuki Todo, 2021. "How does the global network of research collaboration affect the quality of innovation?," The Japanese Economic Review, Springer, vol. 72(1), pages 5-48, January.
    16. Pierre-Alexandre Balland & Ron Boschma & Koen Frenken, 2015. "Proximity and Innovation: From Statics to Dynamics," Regional Studies, Taylor & Francis Journals, vol. 49(6), pages 907-920, June.
    17. Ron Boschma & Pierre-Alexandre Balland & Dieter Kogler, 2011. "A relational approach to knowledge spillovers in biotech. Network structures as drivers of inter-organizational citation patterns," Papers in Evolutionary Economic Geography (PEEG) 1120, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Dec 2011.
    18. Christos Kolympiris & Nicholas Kalaitzandonakes, 2013. "Geographic scope of proximity effects among small life sciences firms," Small Business Economics, Springer, vol. 40(4), pages 1059-1086, May.
    19. Der-Shiuan Lee, 2018. "Towards Urban Resilience through Inter-City Networks of Co-Invention: A Case Study of U.S. Cities," Sustainability, MDPI, vol. 10(2), pages 1-23, January.
    20. Weidenfeld, Adi & Makkonen, Teemu & Clifton, Nick, 2021. "From interregional knowledge networks to systems," Technological Forecasting and Social Change, Elsevier, vol. 171(C).

    More about this item

    Keywords

    Knowledge flows; Regional economics;

    JEL classification:

    • L14 - Industrial Organization - - Market Structure, Firm Strategy, and Market Performance - - - Transactional Relationships; Contracts and Reputation
    • O31 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Innovation and Invention: Processes and Incentives
    • O38 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Government Policy

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:hal:journl:halshs-00981574. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: CCSD (email available below). General contact details of provider: https://hal.archives-ouvertes.fr/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.