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Multistage Modeling of Lung Cancer Mortality Among Arsenic‐Exposed Copper‐Smelter Workers

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  • Sati Mazumdar
  • Carol K. Redmond
  • Philip E. Enterline
  • Gary M. Marsh
  • Joseph P. Costantino
  • Susan Y. J. Zhou
  • Rita N. Patwardhan

Abstract

Multistage modeling incorporating a time‐dependent exposure pattern is applied to lung cancer mortality data obtained from a cohort of 2802 arsenic‐exposed copper‐smelter workers who worked 1 or more years during the period 1940–1964 at a copper smelter at Tacoma, Washington. The workers were followed for death through 1976. There were 100 deaths due to lung cancer during the follow‐up period. Exposures to air arsenic levels measured in μ/m3 were estimated from departmental air arsenic and workers urinary arsenic measurements. Relationships of different temporal variables with excess death rates are examined to judge qualitatively the implications of the multistage cancer process. Analysis to date indicates a late stage effect of arsenic although an additional early stage effect cannot be ruled out.

Suggested Citation

  • Sati Mazumdar & Carol K. Redmond & Philip E. Enterline & Gary M. Marsh & Joseph P. Costantino & Susan Y. J. Zhou & Rita N. Patwardhan, 1989. "Multistage Modeling of Lung Cancer Mortality Among Arsenic‐Exposed Copper‐Smelter Workers," Risk Analysis, John Wiley & Sons, vol. 9(4), pages 551-563, December.
    • Handle: RePEc:wly:riskan:v:9:y:1989:i:4:p:551-563
    DOI: 10.1111/j.1539-6924.1989.tb01266.x
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    References listed on IDEAS

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    1. Kenny S. Clump & Richard B. Howe, 1984. "The Multistage Model with a Time‐Dependent Dose Pattern: Applications to Carcinogenic Risk Assessment," Risk Analysis, John Wiley & Sons, vol. 4(3), pages 163-176, September.
    2. Herman J. Gibb & Chao W. Chen, 1986. "Multistage Model Interpretation of Additive and Multiplicative Carcinogenic Effects," Risk Analysis, John Wiley & Sons, vol. 6(2), pages 167-170, June.
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    Cited by:

    1. Thomas B. Starr & Christine Gause & Ada O. Youk & Roslyn Stone & Gary M. Marsh & James J. Collins, 2004. "A Risk Assessment for Occupational Acrylonitrile Exposure Using Epidemiology Data," Risk Analysis, John Wiley & Sons, vol. 24(3), pages 587-601, June.

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