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Using Average Lifetime Dose Rate for Intermittent Exposures to Carcinogens

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  • Ralph L. Kodell
  • David W. Gaylor
  • James J. Chen

Abstract

The effect of using the average dose rate over a lifetime as a representative measure of exposure to carcinogens is investigated by comparing the true theoretical multistage intermittent‐dosing lifetime low‐dose excess risk to the theoretical multistage continuous‐dosing lifetime risk corresponding to the average lifetime dose rate. It is concluded that low‐dose risk estimates based on the average lifetime dose rate may overestimate the true risk by several orders of magnitude, but that they never underestimate the true risk by more than a factor of k/r, where k is the total number of stages in the multistage model and r is the number of stages that are dose‐related.

Suggested Citation

  • Ralph L. Kodell & David W. Gaylor & James J. Chen, 1987. "Using Average Lifetime Dose Rate for Intermittent Exposures to Carcinogens," Risk Analysis, John Wiley & Sons, vol. 7(3), pages 339-345, September.
    • Handle: RePEc:wly:riskan:v:7:y:1987:i:3:p:339-345
    DOI: 10.1111/j.1539-6924.1987.tb00469.x
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    References listed on IDEAS

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    1. Kenny S. Clump & Richard B. Howe, 1984. "The Multistage Model with a Time‐Dependent Dose Pattern: Applications to Carcinogenic Risk Assessment," Risk Analysis, John Wiley & Sons, vol. 4(3), pages 163-176, September.
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    Cited by:

    1. Frédéric Dor & Roseline Bonnard & Claire Gourier‐Fréry & André Cicolella & Roland Dujardin & Denis Zmirou, 2003. "Health Risk Assessment After Decontamination of the Beaches Polluted by the Wrecked ERIKA Tanker," Risk Analysis, John Wiley & Sons, vol. 23(6), pages 1199-1208, December.
    2. Duncan J. Murdoch & Daniel Krewski & John Wargo, 1992. "Cancer Risk Assessment with Intermittent Exposure," Risk Analysis, John Wiley & Sons, vol. 12(4), pages 569-577, December.

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