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The Multistage Model with a Time‐Dependent Dose Pattern: Applications to Carcinogenic Risk Assessment

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  • Kenny S. Clump
  • Richard B. Howe

Abstract

A cancer risk assessment methodology based upon the Armitage–Doll multistage model of cancer is applied to animal bioassay data. The method utilizes the exact time‐dependent dose pattern used in a bioassay rather than some single measure of dose such as average dose rate or cumulative dose. The methodology can be used to predict risks from arbitrary exposure patterns including, for example, intermittent exposure and short‐term exposure occurring at an arbitrary age. The methodology is illustrated by applying it to a National Cancer Institute bioassay of ethylene dibromide in which dose rates were modified several times during the course of the experiment.

Suggested Citation

  • Kenny S. Clump & Richard B. Howe, 1984. "The Multistage Model with a Time‐Dependent Dose Pattern: Applications to Carcinogenic Risk Assessment," Risk Analysis, John Wiley & Sons, vol. 4(3), pages 163-176, September.
    • Handle: RePEc:wly:riskan:v:4:y:1984:i:3:p:163-176
    DOI: 10.1111/j.1539-6924.1984.tb00136.x
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    Cited by:

    1. Irva Hertz‐Picciotto & Norman Gravitz & Raymond Neutra, 1988. "How Do Cancer Risks Predicted From Animal Bioassays Compare with the Epidemiologic Evidence? The Case of Ethylene Dibromide," Risk Analysis, John Wiley & Sons, vol. 8(2), pages 205-214, June.
    2. Ralph L. Kodell & David W. Gaylor & James J. Chen, 1987. "Using Average Lifetime Dose Rate for Intermittent Exposures to Carcinogens," Risk Analysis, John Wiley & Sons, vol. 7(3), pages 339-345, September.
    3. Herman J. Gibb & Chao W. Chen, 1986. "Multistage Model Interpretation of Additive and Multiplicative Carcinogenic Effects," Risk Analysis, John Wiley & Sons, vol. 6(2), pages 167-170, June.
    4. Sati Mazumdar & Carol K. Redmond & Philip E. Enterline & Gary M. Marsh & Joseph P. Costantino & Susan Y. J. Zhou & Rita N. Patwardhan, 1989. "Multistage Modeling of Lung Cancer Mortality Among Arsenic‐Exposed Copper‐Smelter Workers," Risk Analysis, John Wiley & Sons, vol. 9(4), pages 551-563, December.
    5. Duncan J. Murdoch & Daniel Krewski & John Wargo, 1992. "Cancer Risk Assessment with Intermittent Exposure," Risk Analysis, John Wiley & Sons, vol. 12(4), pages 569-577, December.

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