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Dose Response for Infection by Escherichia coli O157:H7 from Outbreak Data

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  • Peter Teunis
  • Katsuhisa Takumi
  • Kunihiro Shinagawa

Abstract

In 1996, an outbreak of E. coli O157:H7‐associated illness occurred in an elementary school in Japan. This outbreak has been studied in unusual detail, making this an important case for quantitative risk assessment. The availability of stored samples of the contaminated food allowed reliable estimation of exposure to the pathogens. Collection of fecal samples allowed assessment of the numbers infected, including asymptomatic cases. Comparison to other published dose‐response studies for E. coli O157:H7 show that the strain that caused the outbreak studied here must have been considerably more infectious. We use this well‐documented incident as an example to demonstrate how such information on the response to a single dose can be used for dose‐response assessment. In particular, we demonstrate how the high infectivity limits the uncertainty in the low‐dose region.

Suggested Citation

  • Peter Teunis & Katsuhisa Takumi & Kunihiro Shinagawa, 2004. "Dose Response for Infection by Escherichia coli O157:H7 from Outbreak Data," Risk Analysis, John Wiley & Sons, vol. 24(2), pages 401-407, April.
    • Handle: RePEc:wly:riskan:v:24:y:2004:i:2:p:401-407
    DOI: 10.1111/j.0272-4332.2004.00441.x
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    1. Peter F. M. Teunis & Cynthia L. Chappell & Pablo C. Okhuysen, 2002. "Cryptosporidium Dose‐Response Studies: Variation Between Hosts," Risk Analysis, John Wiley & Sons, vol. 22(3), pages 475-485, June.
    2. Peter F. M. Teunis & Nico J. D. Nagelkerke & Charles N. Haas, 1999. "Dose Response Models For Infectious Gastroenteritis," Risk Analysis, John Wiley & Sons, vol. 19(6), pages 1251-1260, December.
    3. Peter F. M. Teunis & Cynthia L. Chappell & Pablo C. Okhuysen, 2002. "Cryptosporidium Dose Response Studies: Variation Between Isolates," Risk Analysis, John Wiley & Sons, vol. 22(1), pages 175-185, February.
    4. P. F. M. Teunis & A. H. Havelaar, 2000. "The Beta Poisson Dose‐Response Model Is Not a Single‐Hit Model," Risk Analysis, John Wiley & Sons, vol. 20(4), pages 513-520, August.
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    7. B. Chapman & K. Pintar & B. A. Smith, 2018. "Multi‐Exposure Pathway Model to Compare Escherichia coli O157 Risks and Interventions," Risk Analysis, John Wiley & Sons, vol. 38(2), pages 392-409, February.
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