Using machine learning for efficient flexible regression adjustment in economic experiments

This study investigates the optimal use of covariates in reducing variance when analyzing experimental data. We show that finding the variance-minimizing strategy for making use of pre-treatment observables is equivalent to estimating the conditional expectation function of the outcome given all available pre-randomization observables. This is a pure prediction problem, which recent advances in machine learning (ML) are well-suited to tackling. Through a number of empirical examples, we show how ML-based regression adjustments can feasibly be implemented in practical settings. We compare our proposed estimator to other standard variance reduction techniques in the literature. Two important advantages of our ML-based regression adjustment estimator are that (i) they improve asymptotic efficiency relative to other alternatives and (ii) they can be implemented automatically, with relatively little tuning from the researcher, which limits the scope for data-snooping.