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Mapping of the acromegaly quality of life questionnaire to ED-5D-5L index score among patients with acromegaly

Author

Listed:
  • Kailu Wang

    (The Chinese University of Hong Kong)

  • Xiaopeng Guo

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council)

  • Siyue Yu

    (The Chinese University of Hong Kong)

  • Lu Gao

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council)

  • Zihao Wang

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council)

  • Huijuan Zhu

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Bing Xing

    (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
    China Pituitary Disease Registry Center
    China Pituitary Adenoma Specialist Council)

  • Shuyang Zhang

    (China Alliance of Rare Diseases
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Dong Dong

    (The Chinese University of Hong Kong
    Shenzhen Research Institute of Chinese University of Hong Kong)

Abstract

Objective This study aimed to develop a mapping function that links the acromegaly quality of life (AcroQoL) questionnaire to EQ-5D-5L to obtain a preference-based utility value to inform economic evaluation. Methods A nationwide cross-sectional questionnaire survey among patients with acromegaly was conducted online in China during 17 December 2019 to 6 January 2020. The study sample was randomly divided into a training set and a validation set. Ordinary least squares (OLS), Tobit, beta-based mixture, and adjusted limited dependent variable mixture models were tested for development of the function in the training set. Total and subscale scores and individual items of AcroQoL were included as predictors in the models along with their squared terms and demographic and clinical characteristics, and selected by backward stepwise selection. The root mean square error, mean absolute error, Akaike’s information criterion, Bayesian information criterion and adjusted R-square were used to assess goodness of fit and predictive ability of the models. Results There were 424 adult patients with acromegaly eligible for this analysis. Average EQ-5D-5L index score and AcroQoL score for them was 0.82 (SD = 0.15) and 44.3 (SD = 22.9), respectively. A total of 60 candidate models were tested. Considering model simplicity and predictive ability in both training and validation set, the best model was the OLS model using scores of physical dimension and its square term as predictors. Conclusion A validated mapping function was developed in this study for estimating EQ-5D scores using AcroQoL outcomes. Its external validity can be further tested in other population with Acromegaly.

Suggested Citation

  • Kailu Wang & Xiaopeng Guo & Siyue Yu & Lu Gao & Zihao Wang & Huijuan Zhu & Bing Xing & Shuyang Zhang & Dong Dong, 2021. "Mapping of the acromegaly quality of life questionnaire to ED-5D-5L index score among patients with acromegaly," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(9), pages 1381-1391, December.
    • Handle: RePEc:spr:eujhec:v:22:y:2021:i:9:d:10.1007_s10198-021-01318-9
    DOI: 10.1007/s10198-021-01318-9
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    References listed on IDEAS

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    More about this item

    Keywords

    Mapping; Quality of life; EQ-5D; Acromegaly; AcroQoL;
    All these keywords.

    JEL classification:

    • I19 - Health, Education, and Welfare - - Health - - - Other

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