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Mapping PedsQL™ Generic Core Scales to EQ-5D-3L utility scores in transfusion-dependent thalassemia patients

Author

Listed:
  • Asrul Akmal Shafie

    (Universiti Sains Malaysia
    Universiti Sains Malaysia)

  • Irwinder Kaur Chhabra

    (Universiti Sains Malaysia
    Sabah Women and Children’s Hospital, Ministry of Health Malaysia)

  • Jacqueline Hui Yi Wong

    (Universiti Sains Malaysia
    Hospital Kuala Lumpur, Ministry of Health Malaysia)

  • Noor Syahireen Mohammed

    (Universiti Sains Malaysia
    Hospital Sultanah Bahiyah, Ministry of Health Malaysia)

Abstract

Purpose To develop a mapping algorithm for generating EQ-5D-3L utility scores from the PedsQL Generic Core Scales (PedsQL GCS) in patients with transfusion-dependent thalassemia (TDT). Methods The algorithm was developed using data from 345 TDT patients. Spearman’s rank correlation was used to evaluate the conceptual overlap between the instruments. Model specifications were chosen using a stepwise regression. Both direct and response mapping methods were attempted. Six mapping estimation methods ordinary least squares (OLS), a log-transformed response using OLS, generalized linear model (GLM), two-part model (TPM), Tobit and multinomial logistic regression (MLOGIT) were tested to determine the root mean squared error (RMSE) and mean absolute error (MAE). Other criterion used were accuracy of the predicted utility score, proportions of absolute differences that was less than 0.03 and intraclass correlation coefficient. An in-sample, leave-one-out cross validation was conducted to test the generalizability of each model. Results The best performing model was specified with three out of the four PedsQL GCS scales—the physical, emotional and social functioning score. The best performing estimation method for direct mapping was a GLM with a RMSE of 0.1273 and MAE of 0.1016, while the best estimation method for response mapping was the MLOGIT with a RMSE of 0.1597 and MAE of 0.0826. Conclusion The mapping algorithm developed using the GLM would facilitate the calculation of utility scores to inform economic evaluations for TDT patients when EQ-5D data is not available. However, caution should be exercised when using this algorithm in patients who have poor quality of life.

Suggested Citation

  • Asrul Akmal Shafie & Irwinder Kaur Chhabra & Jacqueline Hui Yi Wong & Noor Syahireen Mohammed, 2021. "Mapping PedsQL™ Generic Core Scales to EQ-5D-3L utility scores in transfusion-dependent thalassemia patients," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(5), pages 735-747, July.
  • Handle: RePEc:spr:eujhec:v:22:y:2021:i:5:d:10.1007_s10198-021-01287-z
    DOI: 10.1007/s10198-021-01287-z
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    References listed on IDEAS

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    More about this item

    Keywords

    Mapping algorithm; PedsQL; EQ-5D-3L; Utility scores; Quality of life; Thalassemia;
    All these keywords.

    JEL classification:

    • I1 - Health, Education, and Welfare - - Health

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