IDEAS home Printed from https://ideas.repec.org/a/eee/jhecon/v55y2017icp139-152.html
   My bibliography  Save this article

Econometric modelling of multiple self-reports of health states: The switch from EQ-5D-3L to EQ-5D-5L in evaluating drug therapies for rheumatoid arthritis

Author

Listed:
  • Hernández-Alava, Mónica
  • Pudney, Stephen

Abstract

EQ-5D is used in cost-effectiveness studies underlying many important health policy decisions. It comprises a survey instrument describing health states across five domains, and a system of utility values for each state. The original 3-level version of EQ-5D is being replaced with a more sensitive 5-level version but the consequences of this change are uncertain. We develop a multi-equation ordinal response model incorporating a copula specification with normal mixture marginals to analyse joint responses to EQ-5D-3L and EQ-5D-5L in a survey of people with rheumatic disease, and use it to generate mappings between the alternative descriptive systems. We revisit a major cost-effectiveness study of drug therapies for rheumatoid arthritis, mapping the original EQ-5D-3L measure onto a 5L valuation basis. Working within a comprehensive, flexible econometric framework, we find that use of simpler restricted specifications can make very large changes to cost-effectiveness estimates with serious implications for decision-making.

Suggested Citation

  • Hernández-Alava, Mónica & Pudney, Stephen, 2017. "Econometric modelling of multiple self-reports of health states: The switch from EQ-5D-3L to EQ-5D-5L in evaluating drug therapies for rheumatoid arthritis," Journal of Health Economics, Elsevier, vol. 55(C), pages 139-152.
    • Handle: RePEc:eee:jhecon:v:55:y:2017:i:c:p:139-152
    DOI: 10.1016/j.jhealeco.2017.06.013
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0167629616305070
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.jhealeco.2017.06.013?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Nancy J. Devlin & Richard Brooks, 2017. "EQ-5D and the EuroQol Group: Past, Present and Future," Applied Health Economics and Health Policy, Springer, vol. 15(2), pages 127-137, April.
    2. Mónica Hernández-Alava & Stephen Pudney, 2016. "bicop: A command for fitting bivariate ordinal regressions with residual dependence characterized by a copula function and normal mixture marginals," Stata Journal, StataCorp LP, vol. 16(1), pages 159-184, March.
    3. John Brazier & Yaling Yang & Aki Tsuchiya & Donna Rowen, 2010. "A review of studies mapping (or cross walking) non-preference based measures of health to generic preference-based measures," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 11(2), pages 215-225, April.
    4. Anastasios Panagiotelis & Claudia Czado & Harry Joe, 2012. "Pair Copula Constructions for Multivariate Discrete Data," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 107(499), pages 1063-1072, September.
    5. Alastair M. Gray & Oliver Rivero-Arias & Philip M. Clarke, 2006. "Estimating the Association between SF-12 Responses and EQ-5D Utility Values by Response Mapping," Medical Decision Making, , vol. 26(1), pages 18-29, January.
    6. Caterina Conigliani & Andrea Manca & Andrea Tancredi, 2015. "Prediction of patient-reported outcome measures via multivariate ordered probit models," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 178(3), pages 567-591, June.
    7. John Brazier & Aki Tsuchiya, 2015. "Improving Cross-Sector Comparisons: Going Beyond the Health-Related QALY," Applied Health Economics and Health Policy, Springer, vol. 13(6), pages 557-565, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hani Dimassi & Soumana C. Nasser & Aline Issa & Sarine S. Adrian & Bassima Hazimeh, 2021. "Health-Related Quality of Life in Patients with Health Conditions in Lebanese Community Setting," IJERPH, MDPI, vol. 18(16), pages 1-12, August.
    2. Paul Anand & Laurence S. J. Roope & Anthony J. Culyer & Ron Smith, 2020. "Disability and multidimensional quality of life: A capability approach to health status assessment," Health Economics, John Wiley & Sons, Ltd., vol. 29(7), pages 748-765, July.
    3. Ângela Jornada Ben & Johanna M. Dongen & Aureliano Paolo Finch & Mohamed El Alili & Judith E. Bosmans, 2023. "To what extent does the use of crosswalks instead of EQ-5D value sets impact reimbursement decisions?: a simulation study," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 24(8), pages 1253-1270, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ning Gu & Chris Bell & Marc Botteman & Xiang Ji & John Carter & Ben Hout, 2012. "Estimating Preference-Based EQ-5D Health State Utilities or Item Responses from Neuropathic Pain Scores," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 5(3), pages 185-197, September.
    2. Ralph Crott & Andrew Briggs, 2010. "Mapping the QLQ-C30 quality of life cancer questionnaire to EQ-5D patient preferences," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 11(4), pages 427-434, August.
    3. Kailu Wang & Xiaopeng Guo & Siyue Yu & Lu Gao & Zihao Wang & Huijuan Zhu & Bing Xing & Shuyang Zhang & Dong Dong, 2021. "Mapping of the acromegaly quality of life questionnaire to ED-5D-5L index score among patients with acromegaly," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(9), pages 1381-1391, December.
    4. McCarthy, Ian M., 2016. "Eliminating composite bias in treatment effects estimates: Applications to quality of life assessment," Journal of Health Economics, Elsevier, vol. 50(C), pages 47-58.
    5. Pickles, Kristen & Lancsar, Emily & Seymour, Janelle & Parkin, David & Donaldson, Cam & Carter, Stacy M., 2019. "Accounts from developers of generic health state utility instruments explain why they produce different QALYs: A qualitative study," Social Science & Medicine, Elsevier, vol. 240(C).
    6. Pudney, Stephen & Hernandez-Alava, Monica, 2016. "Copula-based modelling of self-reported health states: an application to the use of EQ-5D-3L and EQ-5D-5L in evaluating drug therapies for rheumatic disease," ISER Working Paper Series 2016-04, Institute for Social and Economic Research.
    7. Fan Yang & Nancy Devlin & Nan Luo, 2019. "Impact of mapped EQ-5D utilities on cost-effectiveness analysis: in the case of dialysis treatments," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(1), pages 99-105, February.
    8. Tracey A. Young & Clara Mukuria & Donna Rowen & John E. Brazier & Louise Longworth, 2015. "Mapping Functions in Health-Related Quality of Life," Medical Decision Making, , vol. 35(7), pages 912-926, October.
    9. Fan Yang & Carlos K. H. Wong & Nan Luo & James Piercy & Rebecca Moon & James Jackson, 2019. "Mapping the kidney disease quality of life 36-item short form survey (KDQOL-36) to the EQ-5D-3L and the EQ-5D-5L in patients undergoing dialysis," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(8), pages 1195-1206, November.
    10. Billingsley Kaambwa & Lucinda Billingham & Stirling Bryan, 2013. "Mapping utility scores from the Barthel index," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(2), pages 231-241, April.
    11. Anni Orola & Anna Härri & Jarkko Levänen & Ville Uusitalo & Stig Irving Olsen, 2022. "Assessing WELBY Social Life Cycle Assessment Approach through Cobalt Mining Case Study," Sustainability, MDPI, vol. 14(18), pages 1-26, September.
    12. Mark Oppe & Daniela Ortín-Sulbarán & Carlos Vila Silván & Anabel Estévez-Carrillo & Juan M. Ramos-Goñi, 2021. "Cost-effectiveness of adding Sativex® spray to spasticity care in Belgium: using bootstrapping instead of Monte Carlo simulation for probabilistic sensitivity analyses," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(5), pages 711-721, July.
    13. Jeff Round & Mike Paulden, 2018. "Incorporating equity in economic evaluations: a multi-attribute equity state approach," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 19(4), pages 489-498, May.
    14. Yea-Chan Lee & Da-Hye Son & Yu-Jin Kwon, 2020. "U-Shaped Association between Sleep Duration, C-Reactive Protein, and Uric Acid in Korean Women," IJERPH, MDPI, vol. 17(8), pages 1-11, April.
    15. Mullahy, John, 2024. "Analyzing health outcomes measured as bounded counts," Journal of Health Economics, Elsevier, vol. 95(C).
    16. Lu Yang & Claudia Czado, 2022. "Two‐part D‐vine copula models for longitudinal insurance claim data," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 49(4), pages 1534-1561, December.
    17. Corani, Giorgio & Azzimonti, Dario & Rubattu, Nicolò, 2024. "Probabilistic reconciliation of count time series," International Journal of Forecasting, Elsevier, vol. 40(2), pages 457-469.
    18. Paul Anand & Laurence S. J. Roope & Anthony J. Culyer & Ron Smith, 2020. "Disability and multidimensional quality of life: A capability approach to health status assessment," Health Economics, John Wiley & Sons, Ltd., vol. 29(7), pages 748-765, July.
    19. Brazier, JE & Yang, Y & Tsuchiya, A, 2008. "A review of studies mapping (or cross walking) from non-preference based measures of health to generic preference-based measures," MPRA Paper 29808, University Library of Munich, Germany.
    20. Cubi-Molla, P. & De Vries, J. & Devlin, N., 2013. "A Study of the Relationship Between Health and Subjective Well-being in Parkinson’s Disease Patients," Working Papers 13/12, Department of Economics, City University London.

    More about this item

    Keywords

    EQ-5D; Ordinal response; Copula; Mixture models; Rheumatoid arthritis; Mapping; Cost-effectiveness;
    All these keywords.

    JEL classification:

    • C35 - Mathematical and Quantitative Methods - - Multiple or Simultaneous Equation Models; Multiple Variables - - - Discrete Regression and Qualitative Choice Models; Discrete Regressors; Proportions
    • C83 - Mathematical and Quantitative Methods - - Data Collection and Data Estimation Methodology; Computer Programs - - - Survey Methods; Sampling Methods
    • D61 - Microeconomics - - Welfare Economics - - - Allocative Efficiency; Cost-Benefit Analysis
    • H51 - Public Economics - - National Government Expenditures and Related Policies - - - Government Expenditures and Health
    • I10 - Health, Education, and Welfare - - Health - - - General

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:jhecon:v:55:y:2017:i:c:p:139-152. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/inca/505560 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.