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Determinants of cross-regional R&D collaboration: some empirical evidence from Europe in biotechnology

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  • Cilem Hazir
  • Corinne Autant-Bernard

Abstract

In this study, we focus on the pattern of cross-regional R&D collaborations through which voluntary knowledge flows and accompanying spillovers might occur. Our aim is to investigate the processes that give rise to the observed network configuration in order to identify hampering factors of knowledge diffusion, with a particular interest in the role of geographical proximity and differences in territorial features. We make use of the data on project proposals submitted to the 7th Framework Programme in the field of biotechnology. We build a non-valued inter-regional R&D cooperation network among a set of European regions and study its formation through exponential random graph models (Frank and Strauss in J Am Stat Assoc 81(395):832–842, 1986 ; Wasserman and Pattison in Psychometrika 61(3):401–425, 1996 ). Besides the role played by absorptive capacities, the empirical results reveal that contiguity affects the pattern of cross-regional collaborations not only via edge formation among neighbours but also through a triadic closure process which links neighbouring regions to non-neighbours. Furthermore, triadic closure is found out to be in play among highly populated regions and regions including capital cities. Copyright Springer-Verlag Berlin Heidelberg 2014

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  • Cilem Hazir & Corinne Autant-Bernard, 2014. "Determinants of cross-regional R&D collaboration: some empirical evidence from Europe in biotechnology," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 53(2), pages 369-393, September.
    • Handle: RePEc:spr:anresc:v:53:y:2014:i:2:p:369-393
    DOI: 10.1007/s00168-014-0606-4
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    1. Çilem Selin Hazir, 2013. "Multilateral R&D Collaboration: An ERGM Application on Biotechnology," Advances in Spatial Science, in: Thomas Scherngell (ed.), The Geography of Networks and R&D Collaborations, edition 127, chapter 0, pages 221-237, Springer.
    2. Adam B. Jaffe & Manuel Trajtenberg & Rebecca Henderson, 1993. "Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations," The Quarterly Journal of Economics, President and Fellows of Harvard College, vol. 108(3), pages 577-598.
    3. Jackson, Matthew O. & Wolinsky, Asher, 1996. "A Strategic Model of Social and Economic Networks," Journal of Economic Theory, Elsevier, vol. 71(1), pages 44-74, October.
    4. Cooke, Philip & Gomez Uranga, Mikel & Etxebarria, Goio, 1997. "Regional innovation systems: Institutional and organisational dimensions," Research Policy, Elsevier, vol. 26(4-5), pages 475-491, December.
    5. Jarno Hoekman & Koen Frenken & Frank Oort, 2009. "The geography of collaborative knowledge production in Europe," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 43(3), pages 721-738, September.
    6. Nicolas Carayol & Pascale Roux, 2007. "The Strategic Formation of Interindividual Collaboration Networks. Evidence from Co-invention Patterns," Annals of Economics and Statistics, GENES, issue 87-88, pages 275-301.
    7. Thomas Scherngell & Rafael Lata, 2013. "Towards an integrated European Research Area? Findings from Eigenvector spatially filtered spatial interaction models using European Framework Programme data," Papers in Regional Science, Wiley Blackwell, vol. 92(3), pages 555-577, August.
    8. Hagedoorn, John, 2002. "Inter-firm R&D partnerships: an overview of major trends and patterns since 1960," Research Policy, Elsevier, vol. 31(4), pages 477-492, May.
    9. Hoekman, Jarno & Frenken, Koen & Tijssen, Robert J.W., 2010. "Research collaboration at a distance: Changing spatial patterns of scientific collaboration within Europe," Research Policy, Elsevier, vol. 39(5), pages 662-673, June.
    10. M. S. Gertler & Y. M. Levitte, 2005. "Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation," Industry and Innovation, Taylor & Francis Journals, vol. 12(4), pages 487-507.
    11. C. Autant-Bernard & V. Mangematin & N. Massard, 2006. "Creation of Biotech SMEs in France," Small Business Economics, Springer, vol. 26(2), pages 173-187, March.
    12. repec:bla:econom:v:67:y:2000:i:267:p:307-24 is not listed on IDEAS
    13. Andersson, Martin & Karlsson, Charlie, 2005. "Knowledge Accessibility and Regional Economic Growth," Working Paper Series in Economics and Institutions of Innovation 40, Royal Institute of Technology, CESIS - Centre of Excellence for Science and Innovation Studies.
    14. Paul Almeida & Bruce Kogut, 1999. "Localization of Knowledge and the Mobility of Engineers in Regional Networks," Management Science, INFORMS, vol. 45(7), pages 905-917, July.
    15. Luc Anselin & Attila Varga & Zoltan Acs, 2008. "Geographical Spillovers and University Research: A Spatial Econometric Perspective," Chapters, in: Entrepreneurship, Growth and Public Policy, chapter 10, pages 122-134, Edward Elgar Publishing.
    16. repec:adr:anecst:y:2007:i:87-88:p:13 is not listed on IDEAS
    17. Lundvall, Bengt-Ake & Johnson, Bjorn & Andersen, Esben Sloth & Dalum, Bent, 2002. "National systems of production, innovation and competence building," Research Policy, Elsevier, vol. 31(2), pages 213-231, February.
    18. Robert P. Gilles & Cathleen Johnson, 2000. "original papers : Spatial social networks," Review of Economic Design, Springer;Society for Economic Design, vol. 5(3), pages 273-299.
    19. Beaudry, Catherine & Schiffauerova, Andrea, 2011. "Impacts of collaboration and network indicators on patent quality: The case of Canadian nanotechnology innovation," European Management Journal, Elsevier, vol. 29(5), pages 362-376.
    20. Ron Boschma, 2005. "Proximity and Innovation: A Critical Assessment," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 61-74.
    21. Jason Owen-Smith & Walter W. Powell, 2004. "Knowledge Networks as Channels and Conduits: The Effects of Spillovers in the Boston Biotechnology Community," Organization Science, INFORMS, vol. 15(1), pages 5-21, February.
    22. Stanley Wasserman & Philippa Pattison, 1996. "Logit models and logistic regressions for social networks: I. An introduction to Markov graphs andp," Psychometrika, Springer;The Psychometric Society, vol. 61(3), pages 401-425, September.
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    Cited by:

    1. Lorenzo CASSI & Emilie-Pauline GALLIÉ & Agénor LAHATTE & Valérie MERINDOL, 2018. "Scientific network centrality of European regions: the role of territorial resources," Region et Developpement, Region et Developpement, LEAD, Universite du Sud - Toulon Var, vol. 47, pages 5-26.
    2. Hermans, Frans, 2021. "The contribution of statistical network models to the study of clusters and their evolution," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 100(2), pages 379-403.
    3. Lili Wang & Xianwen Wang & Niels J. Philipsen, 2017. "Network structure of scientific collaborations between China and the EU member states," Scientometrics, Springer;Akadémiai Kiadó, vol. 113(2), pages 765-781, November.
    4. Lili Yuan & Yanni Hao & Minglu Li & Chunbing Bao & Jianping Li & Dengsheng Wu, 2018. "Who are the international research collaboration partners for China? A novel data perspective based on NSFC grants," Scientometrics, Springer;Akadémiai Kiadó, vol. 116(1), pages 401-422, July.
    5. Luigi Aldieri & Gennaro Guida & Maxim Kotsemir & Concetto Paolo Vinci, 2019. "An investigation of impact of research collaboration on academic performance in Italy," Quality & Quantity: International Journal of Methodology, Springer, vol. 53(4), pages 2003-2040, July.
    6. Mitze, Timo & Strotebeck, Falk, 2019. "Determining factors of interregional research collaboration in Germany's biotech network: Capacity, proximity, policy?," Technovation, Elsevier, vol. 80, pages 40-53.
    7. Gergő Tóth & Sándor Juhász & Zoltán Elekes & Balázs Lengyel, 2021. "Repeated collaboration of inventors across European regions," European Planning Studies, Taylor & Francis Journals, vol. 29(12), pages 2252-2272, December.
    8. Mitze, Timo & Strotebeck, Falk, 2017. "Modeling interregional research collaborations in German biotechnology using industry directory data: A quantitative social network analysis," MPRA Paper 83392, University Library of Munich, Germany.
    9. Cilem Selin Hazir & James Lesage & Corinne Autant-Bernard, 2014. "The Role of R&D Collaboration Networks on Regional Innovation Performance," Working Papers halshs-01073031, HAL.
    10. Luqi Li & Ben Derudder & Wei Shen & Xiang Kong, 2022. "Exploring the dynamics of the disaggregated intercity corporate network in the Yangtze River Delta, China: a relational event approach," Journal of Geographical Systems, Springer, vol. 24(1), pages 115-140, January.

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    More about this item

    Keywords

    L14; O31; O38;
    All these keywords.

    JEL classification:

    • L14 - Industrial Organization - - Market Structure, Firm Strategy, and Market Performance - - - Transactional Relationships; Contracts and Reputation
    • O31 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Innovation and Invention: Processes and Incentives
    • O38 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Government Policy

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