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Prognostic and clinicopathological significance of long noncoding RNA MALAT-1 expression in patients with non-small cell lung cancer: A meta-analysis

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  • Xiaoli Liu
  • Guichuan Huang
  • Jing Zhang
  • Longju Zhang
  • Zongan Liang

Abstract

Background: Although expression of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) in tumor tissues has been assessed in several malignancies. However, the association between lncRNA MALAT-1 expression and prognosis or clinicopathological feature remains controversial. Therefore, we conducted a meta-analysis to verify whether lncRNA MALAT-1 expression was associated with prognosis or clinicopathological features in patients with non-small cell lung cancer (NSCLC). Methods: We searched Embase, PubMed, Web of Science, Cochrane library, The Chinese National Knowledge Infrastructure, and Wanfang databases from inception to March, 1, 2020. The language restrictions were Chinese and English. The published literature on lncRNA MALAT-l expression and prognosis or clinicopathological characteristics of NSCLC patients was statistically analyzed. Combined hazard ratios (HRs), odds ratios (OR), and 95% confidence intervals (95% CIs) were used to evaluate the effects of lncRNA MALAT-l on the prognosis and clinicopathological features of NSCLC. Results: Fifteen studies with 1477 NSCLC patients were enrolled. The results showed that the elevated expression of lncRNA MALAT-l in tumor tissues was associated with shorter overall survival (OS) (HR: 2.20, 95% CI: 1.53–3.16; P = 0.000). Additionally, high lncRNA MALAT-l expression was also significantly associated with gender (OR: 0.69, 95% CI: 0.51–0.93; P = 0.014), tumor size (OR: 1.87, 95% CI:1.13–3.09; P = 0.016), lymph node metastasis (LNM) (OR: 2.87, 95% CI:1.05–7.83, P = 0.04), tumor differentiation (OR: 1.60, 95% CI:1.17–2.20; P = 0.003), and tumor-node-metastasis (TNM) stage (OR: 0.42, 95% CI: 0.25–0.70; P = 0.001). There was no significant relationship between lncRNA MALAT-l expression and other clinicopathological features including age (OR: 1.03, 95% CI: 0.79–1.34; P = 0.830), number of tumors (OR: 1.02, 95% CI: 0.63–1.64; P = 0.943), vascular invasion (OR: 1.23, 95% CI: 0.50–3.05; P = 0.652), and recurrence (OR: 1.98, 95% CI: 0.67–5.85; P = 0.214). Conclusion: The overexpression of lncRNA MALAT-l in NSCLC tissues was correlated with OS, gender, tumor size, LNM, tumor differentiation, and TNM stage. Thus, lncRNA MALAT-l may serve as a prognostic factor for NSCLC.

Suggested Citation

  • Xiaoli Liu & Guichuan Huang & Jing Zhang & Longju Zhang & Zongan Liang, 2020. "Prognostic and clinicopathological significance of long noncoding RNA MALAT-1 expression in patients with non-small cell lung cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-16, October.
    • Handle: RePEc:plo:pone00:0240321
    DOI: 10.1371/journal.pone.0240321
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    1. Tom M. Palmer & Jaime L. Peters & Alex J. Sutton & Santiago G. Moreno, 2008. "Contour-enhanced funnel plots for meta-analysis," Stata Journal, StataCorp LP, vol. 8(2), pages 242-254, June.
    2. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
    3. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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