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Association between DNMT3A Mutations and Prognosis of Adults with De Novo Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis

Author

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  • Ruxiu Tie
  • Tiansong Zhang
  • Huarui Fu
  • Limengmeng Wang
  • Yebo Wang
  • Ying He
  • Binsheng Wang
  • Ni Zhu
  • Shan Fu
  • Xiaoyu Lai
  • Jimin Shi
  • He Huang

Abstract

Background: DNA methyltransferase 3A (DNMT3A) mutations were considered to be independently associated with unfavorable prognosis in adults with de novo acute myeloid leukemia (AML), however, there are still debates on this topic. Here, we aim to further investigate the association between DNMT3A mutations and prognosis of patients with AML. Methods: Eligible studies were identified from several data bases including PubMed, Embase, Web of Science, ClinicalTrials and the Cochrane Library (up to June 2013). The primary endpoint was overall survival (OS), while relapse-free survival (RFS) and event-free survival (EFS) were chosen as secondary endpoints. If possible, we would pool estimate effects (hazard ratio [HR] with 95% confidence interval[CI]) of outcomes in random and fixed effects models respectively. Results: That twelve cohort studies with 6377 patients exploring the potential significance of DNMT3A mutations on prognosis were included. Patients with DNMT3A mutations had slightly shorter OS (HR = 1.60; 95% CI, 1.31–1.95; P

Suggested Citation

  • Ruxiu Tie & Tiansong Zhang & Huarui Fu & Limengmeng Wang & Yebo Wang & Ying He & Binsheng Wang & Ni Zhu & Shan Fu & Xiaoyu Lai & Jimin Shi & He Huang, 2014. "Association between DNMT3A Mutations and Prognosis of Adults with De Novo Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0093353
    DOI: 10.1371/journal.pone.0093353
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