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Effect of eliminating CD4-count thresholds on HIV treatment initiation in South Africa: An empirical modeling study

Author

Listed:
  • Jacob Bor
  • Shahira Ahmed
  • Matthew P Fox
  • Sydney Rosen
  • Gesine Meyer-Rath
  • Ingrid T Katz
  • Frank Tanser
  • Deenan Pillay
  • Till Bärnighausen

Abstract

Background: The World Health Organization recommends initiating antiretroviral therapy (ART) regardless of CD4 count. We assessed the effect of ART eligibility on treatment uptake and simulated the impact of WHO’s recommendations in South Africa. Methods: We conducted an empirical analysis of cohort data using a regression discontinuity design, and then used this model for policy simulation. We enrolled all patients (n = 19,279) diagnosed with HIV between August 2011 and December 2013 in the Hlabisa HIV Treatment and Care Programme in rural South Africa. Patients were ART-eligible with CD4

Suggested Citation

  • Jacob Bor & Shahira Ahmed & Matthew P Fox & Sydney Rosen & Gesine Meyer-Rath & Ingrid T Katz & Frank Tanser & Deenan Pillay & Till Bärnighausen, 2017. "Effect of eliminating CD4-count thresholds on HIV treatment initiation in South Africa: An empirical modeling study," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-16, June.
    • Handle: RePEc:plo:pone00:0178249
    DOI: 10.1371/journal.pone.0178249
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    References listed on IDEAS

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    1. Imbens, Guido W. & Lemieux, Thomas, 2008. "Regression discontinuity designs: A guide to practice," Journal of Econometrics, Elsevier, vol. 142(2), pages 615-635, February.
    2. Hahn, Jinyong & Todd, Petra & Van der Klaauw, Wilbert, 2001. "Identification and Estimation of Treatment Effects with a Regression-Discontinuity Design," Econometrica, Econometric Society, vol. 69(1), pages 201-209, January.
    3. David S. Lee & Thomas Lemieux, 2010. "Regression Discontinuity Designs in Economics," Journal of Economic Literature, American Economic Association, vol. 48(2), pages 281-355, June.
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