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Obesity and Risk for Brain/CNS Tumors, Gliomas and Meningiomas: A Meta-Analysis

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  • Theodoros N Sergentanis
  • Georgios Tsivgoulis
  • Christina Perlepe
  • Ioannis Ntanasis-Stathopoulos
  • Ioannis-Georgios Tzanninis
  • Ioannis N Sergentanis
  • Theodora Psaltopoulou

Abstract

Objective: This meta-analysis aims to examine the association between being overweight/obese and risk of meningiomas and gliomas as well as overall brain/central nervous system (CNS) tumors. Study Design: Potentially eligible publications were sought in PubMed up to June 30, 2014. Random-effects meta-analysis and dose-response meta-regression analysis was conducted. Cochran Q statistic, I-squared and tau-squared were used for the assessment of between-study heterogeneity. The analysis was performed using Stata/SE version 13 statistical software. Results: A total of 22 studies were eligible, namely 14 cohort studies (10,219 incident brain/CNS tumor cases, 1,319 meningioma and 2,418 glioma cases in a total cohort size of 10,143,803 subjects) and eight case-control studies (1,009 brain/CNS cases, 1,977 meningioma cases, 1,265 glioma cases and 8,316 controls). In females, overweight status/obesity was associated with increased risk for overall brain/CNS tumors (pooled RR = 1.12, 95%CI: 1.03–1.21, 10 study arms), meningiomas (pooled RR = 1.27, 95%CI: 1.13–1.43, 16 study arms) and gliomas (pooled RR = 1.17, 95%CI: 1.03–1.32, six arms). Obese (BMI>30 kg/m2) females seemed particularly aggravated in terms of brain/CNS tumor (pooled RR = 1.19, 95%CI: 1.05–1.36, six study arms) and meningioma risk (pooled RR = 1.48, 95%CI: 1.28–1.71, seven arms). In males, overweight/obesity status correlated with increased meningioma risk (pooled RR = 1.58, 95%CI: 1.22–2.04, nine study arms), whereas the respective association with overall brain/CNS tumor or glioma risk was not statistically significant. Dose-response meta-regression analysis further validated the findings. Conclusion: Our findings highlight obesity as a risk factor for overall brain/CNS tumors, meningiomas and gliomas among females, as well as for meningiomas among males.

Suggested Citation

  • Theodoros N Sergentanis & Georgios Tsivgoulis & Christina Perlepe & Ioannis Ntanasis-Stathopoulos & Ioannis-Georgios Tzanninis & Ioannis N Sergentanis & Theodora Psaltopoulou, 2015. "Obesity and Risk for Brain/CNS Tumors, Gliomas and Meningiomas: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-29, September.
    • Handle: RePEc:plo:pone00:0136974
    DOI: 10.1371/journal.pone.0136974
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    References listed on IDEAS

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    1. Evangelos Kontopantelis & David A Springate & David Reeves, 2013. "A Re-Analysis of the Cochrane Library Data: The Dangers of Unobserved Heterogeneity in Meta-Analyses," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-14, July.
    2. Chuan Shao & Li-Ping Bai & Zhen-Yu Qi & Guo-Zhen Hui & Zhong Wang, 2014. "Overweight, Obesity and Meningioma Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-7, February.
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