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Efficacy and safety of intravenous laronidase for mucopolysaccharidosis type I: A systematic review and meta-analysis

Author

Listed:
  • Alícia Dorneles Dornelles
  • Osvaldo Artigalás
  • André Anjos da Silva
  • Dora Lucia Vallejo Ardila
  • Taciane Alegra
  • Tiago Veiga Pereira
  • Filippo Pinto e Vairo
  • Ida Vanessa Doederlein Schwartz

Abstract

Objective: To evaluate the efficacy and safety of IV laronidase for MPS I. Methods: A systematic literature review was performed by searching the ClinicalTrials.gov, MEDLINE/PubMed, EMBASE, LILACS, and Cochrane Library databases, limited to clinical trials published until December 31, 2016. The first inclusion criterion was being a randomized controlled trial (RCT). If

Suggested Citation

  • Alícia Dorneles Dornelles & Osvaldo Artigalás & André Anjos da Silva & Dora Lucia Vallejo Ardila & Taciane Alegra & Tiago Veiga Pereira & Filippo Pinto e Vairo & Ida Vanessa Doederlein Schwartz, 2017. "Efficacy and safety of intravenous laronidase for mucopolysaccharidosis type I: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-18, August.
    • Handle: RePEc:plo:pone00:0184065
    DOI: 10.1371/journal.pone.0184065
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    2. Julian P. T. Higgins & Simon G. Thompson & David J. Spiegelhalter, 2009. "A re‐evaluation of random‐effects meta‐analysis," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 172(1), pages 137-159, January.
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