IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0151134.html
   My bibliography  Save this article

Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis

Author

Listed:
  • Xiaoli Hua
  • Lili Yu
  • Ruxu You
  • Yu Yang
  • Jing Liao
  • Dongsheng Chen
  • Lixiu Yu

Abstract

Background: Previous studies have indicated that intake of dietary flavonoids or flavonoid subclasses is associated with the ovarian cancer risk, but presented controversial results. Therefore, we conducted a meta-analysis to derive a more precise estimation of these associations. Methods: We performed a search in PubMed, Google Scholar and ISI Web of Science from their inception to April 25, 2015 to select studies on the association among dietary flavonoids, flavonoid subclasses and ovarian cancer risk. The information was extracted by two independent authors. We assessed the heterogeneity, sensitivity, publication bias and quality of the articles. A random-effects model was used to calculate the pooled risk estimates. Results: Five cohort studies and seven case-control studies were included in the final meta-analysis. We observed that intake of dietary flavonoids can decrease ovarian cancer risk, which was demonstrated by pooled RR (RR = 0.82, 95% CI = 0.68–0.98). In a subgroup analysis by flavonoid subtypes, the ovarian cancer risk was also decreased for isoflavones (RR = 0.67, 95% CI = 0.50–0.92) and flavonols (RR = 0.68, 95% CI = 0.58–0.80). While there was no compelling evidence that consumption of flavones (RR = 0.86, 95% CI = 0.71–1.03) could decrease ovarian cancer risk, which revealed part sources of heterogeneity. The sensitivity analysis indicated stable results, and no publication bias was observed based on the results of Funnel plot analysis and Egger’s test (p = 0.26). Conclusions: This meta-analysis suggested that consumption of dietary flavonoids and subtypes (isoflavones, flavonols) has a protective effect against ovarian cancer with a reduced risk of ovarian cancer except for flavones consumption. Nevertheless, further investigations on a larger population covering more flavonoid subclasses are warranted.

Suggested Citation

  • Xiaoli Hua & Lili Yu & Ruxu You & Yu Yang & Jing Liao & Dongsheng Chen & Lixiu Yu, 2016. "Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-15, March.
    • Handle: RePEc:plo:pone00:0151134
    DOI: 10.1371/journal.pone.0151134
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151134
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0151134&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0151134?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Evangelos Kontopantelis & David A Springate & David Reeves, 2013. "A Re-Analysis of the Cochrane Library Data: The Dangers of Unobserved Heterogeneity in Meta-Analyses," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-14, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Filipe Manuel Clemente & Rodrigo Ramirez-Campillo & José Afonso & Hugo Sarmento & Thomas Rosemann & Beat Knechtle, 2021. "A Meta-Analytical Comparison of the Effects of Small-Sided Games vs. Running-Based High-Intensity Interval Training on Soccer Players’ Repeated-Sprint Ability," IJERPH, MDPI, vol. 18(5), pages 1-11, March.
    2. Zhihua Ye & Xin Zhang & Yihuan Luo & Shikang Li & Lanshan Huang & Zuyun Li & Ping Li & Gang Chen, 2016. "Prognostic Values of Vimentin Expression and Its Clinicopathological Significance in Non-Small Cell Lung Cancer: A Meta-Analysis of Observational Studies with 4118 Cases," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-17, September.
    3. Yan Wang & Lan Huang & Li Zhang & Yi Qu & Dezhi Mu, 2017. "Iron Status in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-14, January.
    4. Lara Carneiro & José Afonso & Rodrigo Ramirez-Campillo & Eugenia Murawska-Ciałowciz & Adilson Marques & Filipe Manuel Clemente, 2020. "The Effects of Exclusively Resistance Training-Based Supervised Programs in People with Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials," IJERPH, MDPI, vol. 17(18), pages 1-22, September.
    5. Ogundeji, Yewande Kofoworola & Bland, John Martin & Sheldon, Trevor Andrew, 2016. "The effectiveness of payment for performance in health care: A meta-analysis and exploration of variation in outcomes," Health Policy, Elsevier, vol. 120(10), pages 1141-1150.
    6. Min Wen & Bo Zhou & Yun-Hua Chen & Zhao-Lei Ma & Yun Gou & Chun-Lin Zhang & Wen-Feng Yu & Ling Jiao, 2017. "Serum uric acid levels in patients with Parkinson’s disease: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.
    7. Tseday Jemaneh Mekasha & Finn Tarp, 2019. "A Meta-Analysis of Aid Effectiveness: Revisiting the Evidence," Politics and Governance, Cogitatio Press, vol. 7(2), pages 5-28.
    8. Rodolfo Castro & Hugo Perazzo & Letícia Artilles Mello Mendonça de Araujo & Isabella Gonçalves Gutierres & Beatriz Grinsztejn & Valdiléa G Veloso, 2020. "Effectiveness of implementing a decentralized delivery of hepatitis C virus treatment with direct-acting antivirals: A systematic review with meta-analysis," PLOS ONE, Public Library of Science, vol. 15(2), pages 1-14, February.
    9. Diandian Li & Yi Liu & Bo Wang, 2020. "Single versus bilateral lung transplantation in idiopathic pulmonary fibrosis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-12, May.
    10. Martina Lori & Sarah Symnaczik & Paul Mäder & Gerlinde De Deyn & Andreas Gattinger, 2017. "Organic farming enhances soil microbial abundance and activity—A meta-analysis and meta-regression," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-25, July.
    11. Falonn Contreras-Osorio & Rodrigo Ramirez-Campillo & Enrique Cerda-Vega & Rodrigo Campos-Jara & Cristian Martínez-Salazar & Rodrigo Araneda & Daniela Ebner-Karestinos & Cristián Arellano-Roco & Christ, 2022. "Effects of Sport-Based Exercise Interventions on Executive Function in Older Adults: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(19), pages 1-19, October.
    12. Pablo Valdés-Badilla & Tomás Herrera-Valenzuela & Rodrigo Ramirez-Campillo & Esteban Aedo-Muñoz & Eduardo Báez-San Martín & Alex Ojeda-Aravena & Braulio Henrique Magnani Branco, 2021. "Effects of Olympic Combat Sports on Older Adults’ Health Status: A Systematic Review," IJERPH, MDPI, vol. 18(14), pages 1-21, July.
    13. Alícia Dorneles Dornelles & Osvaldo Artigalás & André Anjos da Silva & Dora Lucia Vallejo Ardila & Taciane Alegra & Tiago Veiga Pereira & Filippo Pinto e Vairo & Ida Vanessa Doederlein Schwartz, 2017. "Efficacy and safety of intravenous laronidase for mucopolysaccharidosis type I: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-18, August.
    14. Carmen Gasca-Salas & Mario Masellis & Edwin Khoo & Binit B Shah & David Fisman & Anthony E Lang & Galit Kleiner-Fisman, 2016. "Characterization of Movement Disorder Phenomenology in Genetically Proven, Familial Frontotemporal Lobar Degeneration: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-20, April.
    15. Shuangge Liu & Xiaoyan Xin & Teng Hua & Rui Shi & Shuqi Chi & Zhishan Jin & Hongbo Wang, 2016. "Efficacy of Anti-VEGF/VEGFR Agents on Animal Models of Endometriosis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-15, November.
    16. Ming Yang & WenWen Guo & ChunSheng Yang & JianQin Tang & Qian Huang & ShouXin Feng & AiJun Jiang & XiFeng Xu & Guan Jiang, 2017. "Mobile phone use and glioma risk: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-13, May.
    17. Weber, Frank & Knapp, Guido & Glass, Anne & Kundt, Günther & Ickstadt, Katja, 2020. "Interval estimation of the overall treatment effect in random-effects meta-analyses: Recommendations from a simulation study comparing frequentist, Bayesian, and bootstrap methods," OSF Preprints 5zbh6, Center for Open Science.
    18. Antonio Bernabe-Ortiz & Andrea Ruiz-Alejos & J Jaime Miranda & Rohini Mathur & Pablo Perel & Liam Smeeth, 2017. "EZSCAN for undiagnosed type 2 diabetes mellitus: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-11, October.
    19. Neesha Rockwood & Leila H Abdullahi & Robert J Wilkinson & Graeme Meintjes, 2015. "Risk Factors for Acquired Rifamycin and Isoniazid Resistance: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-23, September.
    20. David Daniel Ebert & Anna-Carlotta Zarski & Helen Christensen & Yvonne Stikkelbroek & Pim Cuijpers & Matthias Berking & Heleen Riper, 2015. "Internet and Computer-Based Cognitive Behavioral Therapy for Anxiety and Depression in Youth: A Meta-Analysis of Randomized Controlled Outcome Trials," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-15, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0151134. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.