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ALDH2 and ADH1 Genetic Polymorphisms May Contribute to the Risk of Gastric Cancer: A Meta-Analysis

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  • He-Ling Wang
  • Ping-Yi Zhou
  • Peng Liu
  • Yu Zhang

Abstract

Aim: We conducted a meta-analysis of case-control studies to determine whether ALDH2, ADH1 and ADH2 genetic polymorphisms contribute to the pathogenesis of gastric cancer. Methods: The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. We calculated crude odds ratios (ORs) with their 95% confidence intervals (95%CI) to evaluate their relationships under five genetic models. Seven case-control studies with a total of 2,563 gastric cancer patients and 4,192 healthy controls met the inclusion criteria. Nine common polymorphisms were evaluated, including rs671, rs16941667 and rs886205 in the ALDH2 gene, rs1230025, rs13123099, rs698 and rs1693482 in the ADH1 gene, and rs1229984 and rs17033 in the ADH2 gene. Results: The results of our meta-analysis suggested that ALDH2 genetic polymorphisms might be strongly correlated with an increased risk of gastric cancer (allele model: OR = 1.21, 95%CI: 1.11∼1.32, P 0.05). Conclusion: The current meta-analysis suggests that ALDH2 and ADH1 genetic polymorphisms may play crucial roles in the pathogenesis of gastric cancer. However, ADH2 genetic polymorphisms may not be important dominants of susceptibility to gastric cancer.

Suggested Citation

  • He-Ling Wang & Ping-Yi Zhou & Peng Liu & Yu Zhang, 2014. "ALDH2 and ADH1 Genetic Polymorphisms May Contribute to the Risk of Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0088779
    DOI: 10.1371/journal.pone.0088779
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    Cited by:

    1. Qiang Cai & Jian Wu & Qu Cai & Er-Zhen Chen & Zhao-Yan Jiang, 2015. "Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.
    2. Yunzhong Yang & Tianhua Niu, 2018. "A meta-analysis of associations of LEPR Q223R and K109R polymorphisms with Type 2 diabetes risk," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-25, January.
    3. Sarah Soyeon Oh & Yeong Jun Ju & San Lee & Eun-Cheol Park, 2019. "Primary Reason for Drinking Among Current, Former, and Never Flushing College Students," IJERPH, MDPI, vol. 16(2), pages 1-13, January.

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