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Clinicopathological and Prognostic Significance of Survivin Expression in Patients with Oral Squamous Cell Carcinoma: Evidence from a Meta-Analysis

Author

Listed:
  • Shang Xie
  • Hui Xu
  • Xiaofeng Shan
  • Baozhong Liu
  • Kan Wang
  • Zhigang Cai

Abstract

Background: Survivin has been proposed as a promising prognostic marker in oral squamous cell carcinoma (OSCC), but the published data on survivin expression in patients with this condition are controversial. To address this we performed a meta-analysis systematically to assess the clinicopathological and prognostic significance of survivin expression in OSCC. Methods: We searched PubMed, Embase, Web of Science and Ovid databases for papers investigating the clinicopathological and prognostic significance of survivin expression in OSCC. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to determine the relevance of survivin. Results: A total of 15 papers, including 1040 cases in which survivin expression was detected by immunohistochemistry (IHC) or reverse transcription polymerase chain reaction (RT-PCR), were included. A meta-analysis of clinicopathological variables revealed a correlation between survivin expression and lymph node metastasis (OR = 0.62, 95% CI = 0.44–0.88, p 0.05), depth of invasion (OR = 0.76, 95% CI = 0.50–1.14, p > 0.05), age (OR = 0.78, 95% CI = 0.48–1.29, p > 0.05) or gender (OR = 1.31, 95% CI = 0.86–2.01, p > 0.05). Subgroup analysis using stratified detection methods showed no significant associations between the expression of survivin protein and clinicopathological variables in OSCC. A correlation between survivin expression and poor prognosis of patients with OSCC (HR = 1.62, 95% CI = 1.23–2.01, p

Suggested Citation

  • Shang Xie & Hui Xu & Xiaofeng Shan & Baozhong Liu & Kan Wang & Zhigang Cai, 2015. "Clinicopathological and Prognostic Significance of Survivin Expression in Patients with Oral Squamous Cell Carcinoma: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.
    • Handle: RePEc:plo:pone00:0116517
    DOI: 10.1371/journal.pone.0116517
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    References listed on IDEAS

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    1. Chunguang Li & Zhigang Li & Maoling Zhu & Tiejun Zhao & Ling Chen & Weidan Ji & Hezhong Chen & Changqing Su, 2012. "Clinicopathological and Prognostic Significance of Survivin Over-Expression in Patients with Esophageal Squamous Cell Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    2. Fengzhi Li & Grazia Ambrosini & Emily Y. Chu & Janet Plescia & Simona Tognin & Pier Carlo Marchisio & Dario C. Altieri, 1998. "Control of apoptosis and mitotic spindle checkpoint by survivin," Nature, Nature, vol. 396(6711), pages 580-584, December.
    3. Lou Qian Zhang & Jun Wang & Feng Jiang & Lin Xu & Fu Yin Liu & Rong Yin, 2012. "Prognostic Value of Survivin in Patients with Non-Small Cell Lung Carcinoma: A Systematic Review with Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-9, March.
    4. Andreas Krieg & Thomas A Werner & Pablo E Verde & Nikolas H Stoecklein & Wolfram T Knoefel, 2013. "Prognostic and Clinicopathological Significance of Survivin in Colorectal Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    5. Chanhoo Jeon & Myong Kim & Cheol Kwak & Hyeon Hoe Kim & Ja Hyeon Ku, 2013. "Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-10, October.
    6. Kim, Jaehoon & Kim, Sangsin, 2015. "2012년 국회법 개정의 효과 연구 [A Study on the Effect of the 2012 National Assembly Act Amendment]," KDI Research Monographs, Korea Development Institute (KDI), volume 127, number v:2015-03(k):y:2015:p:1-1.
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